BICLUSTER_ID : UPREG-262
PATHOGENS /3/ : helicobacter pylori,streptococcus pyogenes,ehrlichia chaffeensis
TARGETS /9/ : STAT1, LCN2, XDH, HMOX1, WARS, CCL2, IL6, ICAM1, TLR2
Gene SetLeading Edge Genes
NETPATH IL 4 PATHWAY DOWNSTAT1, UBE2L6, GADD45B, CCL2, GBP2, NFKBIA, TLR3, IL6, ICAM1, CXCL2, IRF1, TLR2, MX1, GZMA
NETPATH IL 1 PATHWAY UPBIRC3, LCN2, CXCL1, WARS, CCL2, CCL7, IL6, PBEF1, ICAM1, MT2A, CXCL2
NCI IL23PATHWAYSTAT1, NFKBIA, IL6, CXCL1, CCL2, CXCL9
GERY CEBP TARGETSGADD45B, LCN2, TRIB3, HMOX1, XDH, SLFN2, JUNB, DDIT3, SLFN4, GADD45G, IFI204 /// LOC672547, CD47, SAA3P, IFI203 /// IFI204 //, TGTP
NETPATH IL 9 PATHWAY UPCCL7, LCN2, CCL2, JUNB, GZMA
NETPATH IL 3 PATHWAY UPCCL7, CSF1, CCL2
NETPATH IL 6 PATHWAY UPSTAT1, GADD45B, CEBPD, JUNB, CEBPB, MAP3K8, NMI, IRF1, MX1
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
NOJIMA SFRP2 TARGETS UP
CHEN HOXA5 TARGETS 6HR UP
MISSIAGLIA REGULATED BY METHYLATION UP
MAHAJAN RESPONSE TO IL1A UP
ZHANG INTERFERON RESPONSE
CHANG IMMORTALIZED BY HPV31 DN
KEGG GRAFT VERSUS HOST DISEASE
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS
AUJLA IL22 AND IL17A SIGNALING
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
LINDSTEDT DENDRITIC CELL MATURATION B
SA MMP CYTOKINE CONNECTION
KRASNOSELSKAYA ILF3 TARGETS UP
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
RADAEVA RESPONSE TO IFNA1 UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP
WALLACE PROSTATE CANCER RACE UP
NCI CD28 DEPENDENT VAV1 PATHWAYCD28, VAV1
KIM LRRC3B TARGETS
WIELAND UP BY HBV INFECTION
WATANABE ULCERATIVE COLITIS WITH CANCER DN
BOWIE RESPONSE TO EXTRACELLULAR MATRIX
ST INTERFERON GAMMA PATHWAY
UROSEVIC RESPONSE TO IMIQUIMOD
BROWNE INTERFERON RESPONSIVE GENES
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP
HARRIS HYPOXIA
NETPATH KIT RECEPTOR PATHWAY UP
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN
ROETH TERT TARGETS UP
DER IFN BETA RESPONSE UP
BIOCARTA LAIR PATHWAY
TSAI DNAJB4 TARGETS UP
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP
ST TYPE I INTERFERON PATHWAY
HINATA NFKB TARGETS KERATINOCYTE UP
GALI TP53 TARGETS APOPTOTIC UP
MARKEY RB1 ACUTE LOF UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
XU AKT1 TARGETS 6HR
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
DER IFN GAMMA RESPONSE UP
MAHADEVAN RESPONSE TO MP470 UP
NCI APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1
ZHAN MULTIPLE MYELOMA LB DN
LIU VAV3 PROSTATE CARCINOGENESIS UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS
DAUER STAT3 TARGETS DN
SANA RESPONSE TO IFNG UP
LIANG SILENCED BY METHYLATION 2
DAUER STAT3 TARGETS UP
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP
NCI CHEMOKINE RECEPTORS BIND CHEMOKINES
LIAN LIPA TARGETS 6M
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
MCLACHLAN DENTAL CARIES UP
DER IFN ALPHA RESPONSE UP
PARK TRETINOIN RESPONSE
CORUM INTERFERON-STIMULATED GENE FACTOR 3 TRANSCRIPTION COMPLEX ISGF3
EINAV INTERFERON SIGNATURE IN CANCER
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
GRANDVAUX IFN RESPONSE NOT VIA IRF3
FARMER BREAST CANCER CLUSTER 1
GRAHAM CML QUIESCENT VS CML DIVIDING UP
BOWIE RESPONSE TO TAMOXIFEN
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHU CMV 8 HR UP
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP
ZHOU INFLAMMATORY RESPONSE LPS UP
GESERICK TERT TARGETS DN
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP
MOSERLE IFNA RESPONSE
WONG ENDMETRIUM CANCER UP
FOSTER INFLAMMATORY RESPONSE LPS UP
CORUM REL-MAP3K8-RELA-TNIP2-PAPOLA COMPLEX
LEE LIVER CANCER MYC E2F1 UP
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
CORUM IFP35-NMI COMPLEX
VERHAAK AML WITH NPM1 MUTATED UP
REACTOME G ALPHA I SIGNALLING EVENTS
LIAN LIPA TARGETS 3M
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
BIOCARTA GRANULOCYTES PATHWAY
GRANDVAUX IRF3 TARGETS UP
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
CORUM NFKB1-NFKB2-REL-RELA-RELB COMPLEX
ZUCCHI METASTASIS DN
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP
PRAMOONJAGO SOX4 TARGETS UP
HINATA NFKB TARGETS FIBROBLAST UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
ehrlichia chaffeensis arkansastreptococcus pyogeneshelicobacter pylori kx1 npgecGeneSet Name
0.00001 0.00471 0.00644NETPATH_IL_4_PATHWAY_DOWN
0.00744 0.03192 0.00201NETPATH_IL_1_PATHWAY_UP
0.00000 0.00014 0.14576NCI_IL23PATHWAY
0.01308 0.01652 0.04422GERY_CEBP_TARGETS
0.00097 0.00011 0.00667NETPATH_IL_9_PATHWAY_UP
0.00000 0.00095 0.05322NETPATH_IL_3_PATHWAY_UP
0.00003 0.00001 0.02074NETPATH_IL_6_PATHWAY_UP
0.00000 0.00010 0.06985KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.01772 0.08281 0.01127NOJIMA_SFRP2_TARGETS_UP
0.01170 0.12534 0.08749CHEN_HOXA5_TARGETS_6HR_UP
0.00123 0.01557 0.00255MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.01198 0.17839 0.00083MAHAJAN_RESPONSE_TO_IL1A_UP
0.00000 0.00000 0.00002ZHANG_INTERFERON_RESPONSE
0.00135 0.02148 0.05281CHANG_IMMORTALIZED_BY_HPV31_DN
0.00000 0.01019 0.07771KEGG_GRAFT_VERSUS_HOST_DISEASE
0.00000 0.08562 0.10299TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP
0.00034 0.00068 0.01155REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
0.00697 0.02059 0.04599AUJLA_IL22_AND_IL17A_SIGNALING
0.00000 0.00000 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.00094 0.00032 0.00213REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.00007 0.02304 0.00011LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00037 0.02244 0.13965SA_MMP_CYTOKINE_CONNECTION
0.00016 0.00396 0.02655KRASNOSELSKAYA_ILF3_TARGETS_UP
0.00307 0.00000 0.10813RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00000 0.00032 0.00003LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00000 0.00000 0.00052RADAEVA_RESPONSE_TO_IFNA1_UP
0.00001 0.00854 0.00740TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP
0.00000 0.00000 0.03695WALLACE_PROSTATE_CANCER_RACE_UP
0.02037 0.12457 0.02411NCI_CD28_DEPENDENT_VAV1_PATHWAY
0.00000 0.00000 0.00152KIM_LRRC3B_TARGETS
0.00000 0.00000 0.03896WIELAND_UP_BY_HBV_INFECTION
0.00128 0.02583 0.12178WATANABE_ULCERATIVE_COLITIS_WITH_CANCER_DN
0.00254 0.00020 0.00059BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX
0.01435 0.02104 0.13122ST_INTERFERON_GAMMA_PATHWAY
0.00000 0.00001 0.00000UROSEVIC_RESPONSE_TO_IMIQUIMOD
0.00000 0.00000 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.00000 0.00000 0.00007TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP
0.00160 0.15102 0.08612HARRIS_HYPOXIA
0.02531 0.02708 0.09166NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00000 0.00016 0.07405FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN
0.01826 0.00062 0.00396ROETH_TERT_TARGETS_UP
0.00030 0.00032 0.00085DER_IFN_BETA_RESPONSE_UP
0.00046 0.00201 0.11387BIOCARTA_LAIR_PATHWAY
0.01306 0.00073 0.08948TSAI_DNAJB4_TARGETS_UP
0.00144 0.19929 0.02451DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP
0.00856 0.10462 0.03013ST_TYPE_I_INTERFERON_PATHWAY
0.00055 0.05930 0.00256HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.05198 0.04180 0.06541GALI_TP53_TARGETS_APOPTOTIC_UP
0.00000 0.00000 0.00008MARKEY_RB1_ACUTE_LOF_UP
0.00013 0.02604 0.06948KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00023 0.12757BASSO_CD40_SIGNALING_UP
0.00698 0.01569 0.01016XU_AKT1_TARGETS_6HR
0.00003 0.00021 0.00009SOUCEK_MYC_TARGETS
0.00000 0.02575 0.05736DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.00616 0.06932DIRMEIER_LMP1_RESPONSE_EARLY
0.00007 0.00000 0.00454DER_IFN_GAMMA_RESPONSE_UP
0.00029 0.01593 0.00000MAHADEVAN_RESPONSE_TO_MP470_UP
0.09494 0.06946 0.00000NCI_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1
0.00000 0.00000 0.00155ZHAN_MULTIPLE_MYELOMA_LB_DN
0.00000 0.00000 0.13833LIU_VAV3_PROSTATE_CARCINOGENESIS_UP
0.00000 0.00007 0.00000REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00001 0.00000 0.00051SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP
0.00000 0.00004 0.00000BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS
0.00007 0.00003 0.00003DAUER_STAT3_TARGETS_DN
0.00000 0.00000 0.00000SANA_RESPONSE_TO_IFNG_UP
0.00001 0.00099 0.00000LIANG_SILENCED_BY_METHYLATION_2
0.01097 0.00038 0.01934DAUER_STAT3_TARGETS_UP
0.00000 0.00012 0.10968NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP
0.06101 0.03180 0.00902NCI_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00000 0.00004 0.05227LIAN_LIPA_TARGETS_6M
0.01021 0.01028 0.14559NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.00000 0.00000 0.02102MCLACHLAN_DENTAL_CARIES_UP
0.00000 0.00000 0.00025DER_IFN_ALPHA_RESPONSE_UP
0.00097 0.14849 0.04031PARK_TRETINOIN_RESPONSE
0.10550 0.15209 0.19009CORUM_INTERFERON-STIMULATED_GENE_FACTOR_3_TRANSCRIPTION_COMPLEX_ISGF3
0.00023 0.00000 0.00000EINAV_INTERFERON_SIGNATURE_IN_CANCER
0.00000 0.00000 0.06509MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00000GAURNIER_PSMD4_TARGETS
0.00010 0.00000 0.00007GRANDVAUX_IFN_RESPONSE_NOT_VIA_IRF3
0.00000 0.00000 0.00000FARMER_BREAST_CANCER_CLUSTER_1
0.00007 0.05533 0.00796GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00015 0.00016 0.00007BOWIE_RESPONSE_TO_TAMOXIFEN
0.00000 0.00019 0.00002ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00000 0.00367 0.00000ZHU_CMV_8_HR_UP
0.00000 0.00000 0.15656ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP
0.00269 0.06782 0.00001ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00047 0.01538 0.01048GESERICK_TERT_TARGETS_DN
0.03146 0.19333 0.04107BIOCARTA_INFLAM_PATHWAY
0.00000 0.00000 0.00000SANA_TNF_SIGNALING_UP
0.00104 0.00957 0.02651TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP
0.00000 0.00000 0.00000MOSERLE_IFNA_RESPONSE
0.02264 0.00076 0.09571WONG_ENDMETRIUM_CANCER_UP
0.00000 0.00000 0.03879FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.10047 0.04834 0.05756CORUM_REL-MAP3K8-RELA-TNIP2-PAPOLA_COMPLEX
0.00000 0.01825 0.16806LEE_LIVER_CANCER_MYC_E2F1_UP
0.00262 0.09492 0.06147HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.14467 0.17145 0.18380CORUM_IFP35-NMI_COMPLEX
0.00000 0.01128 0.06454VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00009 0.01622 0.16706REACTOME_G_ALPHA_I_SIGNALLING_EVENTS
0.00000 0.00004 0.09060LIAN_LIPA_TARGETS_3M
0.00175 0.01876 0.00002GEISS_RESPONSE_TO_DSRNA_UP
0.01044 0.04007 0.00515KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00024 0.01558 0.00519BIOCARTA_GRANULOCYTES_PATHWAY
0.00446 0.00549 0.00989GRANDVAUX_IRF3_TARGETS_UP
0.00003 0.00455 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.00053 0.06342 0.00201ZHU_CMV_ALL_UP
0.00000 0.00011 0.14588KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00001 0.05507 0.00039GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.16701 0.17781 0.03228CORUM_NFKB1-NFKB2-REL-RELA-RELB_COMPLEX
0.10538 0.01684 0.02425ZUCCHI_METASTASIS_DN
0.00000 0.01025 0.09552BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP
0.07569 0.19931 0.00004PRAMOONJAGO_SOX4_TARGETS_UP
0.00358 0.14412 0.05134HINATA_NFKB_TARGETS_FIBROBLAST_UP