BICLUSTER_ID : UPREG-282
PATHOGENS /4/ : pseudomonas aeruginosa,lactobacillus acidophilus,brucella ovis,ehrlichia chaffeensis
TARGETS /5/ : SERPINE1, IL1B, CCL5, CCL2, TNF
Gene SetLeading Edge Genes
NETPATH IL 2 PATHWAY UPNMI, SOCS3, SERPINE1, CCL3, IL1B, UPP1, TNF, CCL4
NETPATH IL 1 PATHWAY UPBIRC3, IL1B, SERPINE1, CCL2, CXCL2, CCL4
SA MMP CYTOKINE CONNECTIONIL1B, TNF
NETPATH IL 3 PATHWAY UPSOCS3, IL1B, CCL2, CCL4
NETPATH IL 5 PATHWAY UPBIRC3, IL1B, CCL3, CCL2
NCI IL23PATHWAYSOCS3, IL1B, CCL2
NETPATH IL 9 PATHWAY UPSOCS3, CCL3, CCL2
NETPATH IL 4 PATHWAY DOWNCCL2, CXCL2
NETPATH IL 7 PATHWAY UPCCL5, CXCL2, CCL4
NETPATH IL 6 PATHWAY UPSOCS3, IRF1, TNF
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
WEINMANN ADAPTATION TO HYPOXIA DN
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS
AUJLA IL22 AND IL17A SIGNALING
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
CROONQUIST STROMAL STIMULATION UP
LINDSTEDT DENDRITIC CELL MATURATION B
BIOCARTA IL1R PATHWAY
LINDSTEDT DENDRITIC CELL MATURATION A
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
BROWNE INTERFERON RESPONSIVE GENES
NCI DISSOLUTION OF FIBRIN CLOT
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP
HINATA NFKB TARGETS KERATINOCYTE UP
SEIKE LUNG CANCER POOR SURVIVAL
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
FERRARI RESPONSE TO FENRETINIDE UP
BILD HRAS ONCOGENIC SIGNATURE
ZHOU INFLAMMATORY RESPONSE LIVE UP
ONDER CDH1 TARGETS 3 DN
AMIT EGF RESPONSE 120 HELA
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
KEGG LEISHMANIA INFECTION
MCLACHLAN DENTAL CARIES UP
JAATINEN HEMATOPOIETIC STEM CELL DN
DAZARD UV RESPONSE CLUSTER G2
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 40 MCF10A
GAURNIER PSMD4 TARGETS
HELLER SILENCED BY METHYLATION UP
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHOU INFLAMMATORY RESPONSE LPS UP
SMID BREAST CANCER LUMINAL B DN
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
ONDER CDH1 TARGETS 2 DN
SESTO RESPONSE TO UV C3
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
VERHAAK AML WITH NPM1 MUTATED UP
PEPPER CHRONIC LYMPHOCYTIC LEUKEMIA UP
LIAN LIPA TARGETS 3M
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1
BIOCARTA GRANULOCYTES PATHWAY
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN
AMIT EGF RESPONSE 60 MCF10A
HINATA NFKB TARGETS FIBROBLAST UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
lactobacillus acidophiluspseudomonas aeruginosabrucella ovisehrlichia chaffeensis libertyGeneSet Name
0.01173 0.11013 0.18663 0.01786NETPATH_IL_2_PATHWAY_UP
0.00114 0.00004 0.01452 0.04640NETPATH_IL_1_PATHWAY_UP
0.11732 0.04053 0.18285 0.00029SA_MMP_CYTOKINE_CONNECTION
0.00372 0.01596 0.00156 0.00030NETPATH_IL_3_PATHWAY_UP
0.01533 0.00238 0.03173 0.05924NETPATH_IL_5_PATHWAY_UP
0.00000 0.00049 0.05836 0.00440NCI_IL23PATHWAY
0.01316 0.06627 0.00706 0.00207NETPATH_IL_9_PATHWAY_UP
0.00012 0.00000 0.00062 0.00340NETPATH_IL_4_PATHWAY_DOWN
0.06237 0.00151 0.01316 0.00005NETPATH_IL_7_PATHWAY_UP
0.00006 0.01244 0.01065 0.00150NETPATH_IL_6_PATHWAY_UP
0.00000 0.00066 0.03342 0.00077KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00598 0.00003 0.01964 0.09755OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00008 0.01558 0.07308 0.01105GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.05378 0.03347 0.07459 0.11374WEINMANN_ADAPTATION_TO_HYPOXIA_DN
0.07905 0.00044 0.16085 0.10026REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
0.00386 0.04032 0.13604 0.12142AUJLA_IL22_AND_IL17A_SIGNALING
0.00000 0.00016 0.03248 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.04711 0.01456 0.01979 0.00903CROONQUIST_STROMAL_STIMULATION_UP
0.00000 0.00005 0.02851 0.02223LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.02532 0.02041 0.03199 0.06455BIOCARTA_IL1R_PATHWAY
0.00000 0.00387 0.00044 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.09352 0.00381 0.06140 0.01294THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00000 0.10336 0.12548 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.12052 0.02604 0.16625 0.11045NCI_DISSOLUTION_OF_FIBRIN_CLOT
0.00372 0.13363 0.18029 0.06656TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP
0.00000 0.00000 0.03817 0.00058HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00139 0.09189 0.05722 0.01750SEIKE_LUNG_CANCER_POOR_SURVIVAL
0.00000 0.00004 0.05857 0.00966KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00006 0.08843 0.00000BASSO_CD40_SIGNALING_UP
0.00010 0.00251 0.00716 0.00038SOUCEK_MYC_TARGETS
0.00233 0.00086 0.01264 0.00023DUTTA_APOPTOSIS_VIA_NFKB
0.00007 0.00000 0.01330 0.00342DIRMEIER_LMP1_RESPONSE_EARLY
0.00017 0.00003 0.05049 0.00023REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.15133 0.00003 0.08101 0.18558FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00628 0.00110 0.06372 0.05938BILD_HRAS_ONCOGENIC_SIGNATURE
0.00000 0.00000 0.00746 0.05362ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00174 0.00003 0.00115 0.16184ONDER_CDH1_TARGETS_3_DN
0.09453 0.00184 0.12378 0.00639AMIT_EGF_RESPONSE_120_HELA
0.00259 0.00006 0.10980 0.06350DAUER_STAT3_TARGETS_UP
0.00000 0.00126 0.03860 0.00000LIANG_SILENCED_BY_METHYLATION_2
0.00174 0.00366 0.13650 0.00000KEGG_LEISHMANIA_INFECTION
0.00667 0.00000 0.03202 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.11272 0.03113 0.16593 0.00000JAATINEN_HEMATOPOIETIC_STEM_CELL_DN
0.06213 0.01158 0.14937 0.05324DAZARD_UV_RESPONSE_CLUSTER_G2
0.00000 0.00185 0.01159 0.00078FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.01242 0.00005 0.04417 0.00000MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00076 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00031 0.00028 0.08142 0.03677AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00036 0.00581 0.00000GAURNIER_PSMD4_TARGETS
0.00489 0.17408 0.11472 0.00000HELLER_SILENCED_BY_METHYLATION_UP
0.00000 0.00000 0.05672 0.00022GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00000 0.00055 0.00059ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00000 0.00043 0.04278 0.03822ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.07352 0.04524 0.19116 0.00253SMID_BREAST_CANCER_LUMINAL_B_DN
0.00000 0.08424 0.00765 0.02390BIOCARTA_INFLAM_PATHWAY
0.00000 0.00000 0.01931 0.00008SANA_TNF_SIGNALING_UP
0.02211 0.00503 0.13624 0.03586ONDER_CDH1_TARGETS_2_DN
0.02540 0.00703 0.12374 0.11456SESTO_RESPONSE_TO_UV_C3
0.11701 0.00000 0.00038 0.02652HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.03043 0.00267 0.08159 0.00000VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.02705 0.19677 0.08045 0.03685PEPPER_CHRONIC_LYMPHOCYTIC_LEUKEMIA_UP
0.02013 0.12753 0.10503 0.00000LIAN_LIPA_TARGETS_3M
0.00027 0.00051 0.08028 0.01274GEISS_RESPONSE_TO_DSRNA_UP
0.00033 0.00006 0.03178 0.05665KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.03748 0.00002 0.01384 0.10221UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.12179 0.00537 0.19115 0.17607SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1
0.01385 0.04859 0.05900 0.00128BIOCARTA_GRANULOCYTES_PATHWAY
0.00000 0.00000 0.02617 0.02222TIAN_TNF_SIGNALING_VIA_NFKB
0.00466 0.13854 0.06104 0.06440ZHU_CMV_ALL_UP
0.00000 0.00027 0.13418 0.00866KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00000 0.00040 0.00033GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00475 0.00003 0.01906 0.10357OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.04137 0.00093 0.15857 0.02333LEE_LIVER_CANCER_HEPATOBLAST
0.04132 0.00002 0.10002 0.05374ZUCCHI_METASTASIS_DN
0.05878 0.00102 0.19801 0.01422NAGASHIMA_EGF_SIGNALING_UP
0.01593 0.00340 0.06117 0.03067BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP
0.03196 0.06344 0.05093 0.17601CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN
0.00978 0.00367 0.03197 0.06686AMIT_EGF_RESPONSE_60_MCF10A
0.01167 0.00000 0.16302 0.00960HINATA_NFKB_TARGETS_FIBROBLAST_UP