BICLUSTER_ID : UPREG-300
PATHOGENS /3/ : yersinia enterocolitica,helicobacter pylori,shigella dysenteriae
TARGETS /8/ : NFKB1, CCL20, JUN, CCL2, HK1, PTGS2, SERPINE1, NGFB
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPCCL20, LIF, JUN, CXCL1, CCL2, HBEGF, PTGS2, PBEF1, MT2A, CXCL2, MYC, PTX3, CCL4
NCI HIF1 TFPATHWAYPFKFB3, HK2, JUN, CITED2, RORA, SERPINE1, HK1, ADM, BHLHB2
ST TUMOR NECROSIS FACTOR PATHWAYNFKB1, TNFAIP3, JUN, NFKBIE
NETPATH IL 9 PATHWAY UPCCL2, JUNB, CITED2, MYC
NETPATH KIT RECEPTOR PATHWAY UPATF4, JUNB, CCL2, MYC, IER3
NETPATH IL 3 PATHWAY UPCSF1, CCL2, MYC, CCL4
NETPATH IL 6 PATHWAY UPSGK, GADD45B, JUN, CXCL1, JUNB, CEBPB, HBEGF, MAP3K8, MAFF
GERY CEBP TARGETSGADD45B, CXCL1, EREG, JUNB, HBEGF, GADD45G, ATF3, NGFB, DUSP1, PTX3
NOJIMA SFRP2 TARGETS UP
CHEN HOXA5 TARGETS 6HR UP
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
LEONARD HYPOXIA
TURJANSKI MAPK7 TARGETS
CORUM UBIQUITIN E3 LIGASE NFKBIA FBXW11 CUL1 SKP1A
MAHAJAN RESPONSE TO IL1A UP
RODRIGUES NTN1 AND DCC TARGETS
LINDSTEDT DENDRITIC CELL MATURATION B
SA MMP CYTOKINE CONNECTION
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
ELVIDGE HYPOXIA UP
KIM LRRC3B TARGETS
IYENGAR RESPONSE TO ADIPOCYTE FACTORS
AMIT EGF RESPONSE 40 HELA
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN
NETPATH IL 4 PATHWAY DOWN
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5
DORN ADENOVIRUS INFECTION 12HR UP
MAHADEVAN RESPONSE TO MP470 DN
DORN ADENOVIRUS INFECTION 32HR UP
HARRIS HYPOXIA
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP
HINATA NFKB TARGETS KERATINOCYTE UP
GENTILE UV HIGH DOSE UP
MARKEY RB1 ACUTE LOF UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
ZERBINI RESPONSE TO SULINDAC UP
DIRMEIER LMP1 RESPONSE EARLY
WOTTON RUNX TARGETS UP
MAHADEVAN RESPONSE TO MP470 UP
FERRARI RESPONSE TO FENRETINIDE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
BIOCARTA CD40 PATHWAY
BILD HRAS ONCOGENIC SIGNATURE
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
BIOCARTA RANKL PATHWAY
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
MCLACHLAN DENTAL CARIES UP
MENSE HYPOXIA UPMAFF, PFKFB3, ATF3, PBEF1, CEBPB, ADM, BHLHB2, TIPARP
NCI NF KB IS ACTIVATED AND SIGNALS SURVIVAL
CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX CHUK KPNA3 NFKB2 NFKBIB REL IKBKG NFKB1 NFKBIE RELB NFKBIA RELA TNIP2
CHEN HOXA5 TARGETS 9HR UP
DAZARD UV RESPONSE CLUSTER G2
NCI CD40 PATHWAY
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 40 MCF10A
GAURNIER PSMD4 TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
HELLER SILENCED BY METHYLATION DN
BIERIE INFLAMMATORY RESPONSE TGFB1
NCI IL23PATHWAY
ZHOU INFLAMMATORY RESPONSE LPS UP
GESERICK TERT TARGETS DN
SANA TNF SIGNALING UP
BROWNE HCMV INFECTION 2HR UP
XU HGF TARGETS INDUCED BY AKT1 6HR
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
VERHAAK AML WITH NPM1 MUTATED UP
GEISS RESPONSE TO DSRNA UP
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
KOBAYASHI EGFR SIGNALING 6HR DN
BIOCARTA GRANULOCYTES PATHWAY
BIOCARTA TNFR2 PATHWAY
ELVIDGE HYPOXIA BY DMOG UP
AMIT EGF RESPONSE 120 MCF10A
TIAN TNF SIGNALING VIA NFKB
FARMER BREAST CANCER CLUSTER 3
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
FARMER BREAST CANCER CLUSTER 4
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
CORUM NFKB1-NFKB2-REL-RELA-RELB COMPLEX
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
KRIGE AMINO ACID DEPRIVATION
PRAMOONJAGO SOX4 TARGETS UP
CORUM ETS2-FOS-JUN COMPLEX
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica wap bcshigella dysenteriaehelicobacter pylori kx1 npgecGeneSet Name
0.00001 0.00030 0.00201NETPATH_IL_1_PATHWAY_UP
0.03883 0.08693 0.07013NCI_HIF1_TFPATHWAY
0.02172 0.01233 0.01817ST_TUMOR_NECROSIS_FACTOR_PATHWAY
0.00001 0.05058 0.00667NETPATH_IL_9_PATHWAY_UP
0.00004 0.00112 0.09166NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00000 0.00147 0.05322NETPATH_IL_3_PATHWAY_UP
0.00000 0.00000 0.02074NETPATH_IL_6_PATHWAY_UP
0.00013 0.00067 0.04422GERY_CEBP_TARGETS
0.00224 0.00035 0.01127NOJIMA_SFRP2_TARGETS_UP
0.01068 0.00221 0.08749CHEN_HOXA5_TARGETS_6HR_UP
0.00107 0.00484 0.00255MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00000 0.00000 0.09695OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00000 0.00252 0.18497GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00652 0.01701 0.00008LEONARD_HYPOXIA
0.15706 0.07009 0.05774TURJANSKI_MAPK7_TARGETS
0.15117 0.17968 0.14373CORUM_UBIQUITIN_E3_LIGASE_NFKBIA_FBXW11_CUL1_SKP1A
0.00000 0.00316 0.00083MAHAJAN_RESPONSE_TO_IL1A_UP
0.07345 0.00147 0.04134RODRIGUES_NTN1_AND_DCC_TARGETS
0.00004 0.00053 0.00011LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00860 0.10485 0.13965SA_MMP_CYTOKINE_CONNECTION
0.00001 0.00004 0.10813RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00000 0.00034 0.00003LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00006 0.00124 0.11617ELVIDGE_HYPOXIA_UP
0.00014 0.07873 0.00152KIM_LRRC3B_TARGETS
0.06007 0.00648 0.00098IYENGAR_RESPONSE_TO_ADIPOCYTE_FACTORS
0.00018 0.00000 0.12195AMIT_EGF_RESPONSE_40_HELA
0.01934 0.15816 0.09623GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_DN
0.00024 0.16501 0.00644NETPATH_IL_4_PATHWAY_DOWN
0.01552 0.02126 0.02657YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5
0.01175 0.00527 0.05966DORN_ADENOVIRUS_INFECTION_12HR_UP
0.00006 0.00000 0.09518MAHADEVAN_RESPONSE_TO_MP470_DN
0.09531 0.09973 0.12035DORN_ADENOVIRUS_INFECTION_32HR_UP
0.00004 0.00501 0.08612HARRIS_HYPOXIA
0.00000 0.18893 0.07405FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN
0.00012 0.00000 0.02451DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP
0.00000 0.00078 0.00256HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.02916 0.04599 0.12131GENTILE_UV_HIGH_DOSE_UP
0.00001 0.14227 0.00008MARKEY_RB1_ACUTE_LOF_UP
0.00000 0.00096 0.06948KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00004 0.12757BASSO_CD40_SIGNALING_UP
0.00001 0.02047 0.00009SOUCEK_MYC_TARGETS
0.00003 0.02611 0.05736DUTTA_APOPTOSIS_VIA_NFKB
0.16203 0.07968 0.06538ZERBINI_RESPONSE_TO_SULINDAC_UP
0.00000 0.00000 0.06932DIRMEIER_LMP1_RESPONSE_EARLY
0.02102 0.18706 0.19024WOTTON_RUNX_TARGETS_UP
0.00006 0.06328 0.00000MAHADEVAN_RESPONSE_TO_MP470_UP
0.00007 0.00712 0.11271FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00000 0.17156 0.00000REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.09812 0.00438 0.13504BIOCARTA_CD40_PATHWAY
0.00000 0.00000 0.16783BILD_HRAS_ONCOGENIC_SIGNATURE
0.06147 0.00005 0.01934DAUER_STAT3_TARGETS_UP
0.00007 0.00396 0.00000LIANG_SILENCED_BY_METHYLATION_2
0.02104 0.15704 0.04517BIOCARTA_RANKL_PATHWAY
0.00012 0.13279 0.14559NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.00000 0.01598 0.02102MCLACHLAN_DENTAL_CARIES_UP
0.00167 0.02114 0.00732MENSE_HYPOXIA_UP
0.11013 0.04605 0.19145NCI_NF_KB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL
0.05725 0.04735 0.10289CORUM_TNF-ALPHA/NF-KAPPA_B_SIGNALING_COMPLEX_CHUK_KPNA3_NFKB2_NFKBIB_REL_IKBKG__NFKB1_NFKBIE_RELB__NFKBIA_RELA_TNIP2
0.00001 0.00000 0.00899CHEN_HOXA5_TARGETS_9HR_UP
0.00772 0.00032 0.15355DAZARD_UV_RESPONSE_CLUSTER_G2
0.03530 0.00073 0.14335NCI_CD40_PATHWAY
0.00001 0.02949 0.06509MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.13910AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.04466 0.00000GAURNIER_PSMD4_TARGETS
0.00008 0.00003 0.00796GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00000 0.00002ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00072 0.07958 0.03147HELLER_SILENCED_BY_METHYLATION_DN
0.00509 0.05553 0.00805BIERIE_INFLAMMATORY_RESPONSE_TGFB1
0.00001 0.09953 0.14576NCI_IL23PATHWAY
0.00000 0.03754 0.00001ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.01048GESERICK_TERT_TARGETS_DN
0.00000 0.00530 0.00000SANA_TNF_SIGNALING_UP
0.02213 0.00008 0.02678BROWNE_HCMV_INFECTION_2HR_UP
0.00321 0.07814 0.01849XU_HGF_TARGETS_INDUCED_BY_AKT1_6HR
0.00000 0.00000 0.06147HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00000 0.00095 0.06454VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00000 0.01687 0.00002GEISS_RESPONSE_TO_DSRNA_UP
0.00000 0.00000 0.00603UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.14658 0.00127 0.10830KOBAYASHI_EGFR_SIGNALING_6HR_DN
0.00514 0.18726 0.00519BIOCARTA_GRANULOCYTES_PATHWAY
0.14415 0.00110 0.02476BIOCARTA_TNFR2_PATHWAY
0.00045 0.00078 0.06336ELVIDGE_HYPOXIA_BY_DMOG_UP
0.00001 0.02002 0.19126AMIT_EGF_RESPONSE_120_MCF10A
0.00000 0.00005 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.11305 0.00779 0.02765FARMER_BREAST_CANCER_CLUSTER_3
0.00000 0.00000 0.00039GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.08461 0.00883 0.04086FARMER_BREAST_CANCER_CLUSTER_4
0.00000 0.00000 0.10013OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00193 0.00154 0.18870LEE_LIVER_CANCER_HEPATOBLAST
0.10174 0.19006 0.03228CORUM_NFKB1-NFKB2-REL-RELA-RELB_COMPLEX
0.00010 0.00013 0.02425ZUCCHI_METASTASIS_DN
0.00000 0.00000 0.01564NAGASHIMA_EGF_SIGNALING_UP
0.00024 0.03473 0.00155KRIGE_AMINO_ACID_DEPRIVATION
0.00024 0.00000 0.00004PRAMOONJAGO_SOX4_TARGETS_UP
0.09984 0.14136 0.10242CORUM_ETS2-FOS-JUN_COMPLEX
0.00000 0.00000 0.15432PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN
0.00001 0.00153 0.05134HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00000 0.00000 0.04711AMIT_EGF_RESPONSE_60_MCF10A