BICLUSTER_ID : UPREG-302
PATHOGENS /3/ : brucella neotomae,helicobacter pylori,mycobacterium tuberculosis
TARGETS /10/ : NFKB1, STAT1, CCL2, TNFRSF1B, IL6, GCH1, PTGS2, CCL5, ICAM1, PIM1
Gene SetLeading Edge Genes
NETPATH IL 4 PATHWAY DOWNSTAT1, GADD45B, CCL2, GBP2, NFKBIA, PTGS2, ICAM1, CXCL2, MX1
NETPATH KIT RECEPTOR PATHWAY UPIL6, JUNB, CCL5, CCL2, PIM1, IER3
NETPATH IL 1 PATHWAY UPBIRC3, CCL2, HBEGF, NFKBIA, IL6, PTGS2, ICAM1, CXCL2, SOD2, CCL4
NETPATH IL 3 PATHWAY UPCCL2, PIM1, CCL4
NETPATH IL 6 PATHWAY UPSTAT1, GADD45B, CEBPD, JUNB, BCL3, HBEGF, NMI, PIM1, MX1
GERY CEBP TARGETSATF3, GADD45B, GCH1, EREG, JUNB, PIM1, HBEGF
ST TUMOR NECROSIS FACTOR PATHWAYNFKB1, NFKBIA, BIRC3, NFKB2, TNFRSF1B
NCI NFKAPPABALTERNATIVEPATHWAYNFKB1, NFKB2
NCI IL23PATHWAYNFKBIA, CCL2
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
CHEN HOXA5 TARGETS 6HR UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
LEONARD HYPOXIA
NETPATH IL 9 PATHWAY UP
MAHAJAN RESPONSE TO IL1A UP
BIOCARTA EPONFKB PATHWAY
ZHANG INTERFERON RESPONSE
KEGG GRAFT VERSUS HOST DISEASE
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
LINDSTEDT DENDRITIC CELL MATURATION B
SA MMP CYTOKINE CONNECTION
LINDSTEDT DENDRITIC CELL MATURATION A
RADAEVA RESPONSE TO IFNA1 UP
ELVIDGE HYPOXIA UP
KIM LRRC3B TARGETS
AMIT EGF RESPONSE 40 HELA
BOWIE RESPONSE TO EXTRACELLULAR MATRIX
DORN ADENOVIRUS INFECTION 12HR UP
MAHADEVAN RESPONSE TO MP470 DN
UROSEVIC RESPONSE TO IMIQUIMOD
BROWNE INTERFERON RESPONSIVE GENES
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP
HARRIS HYPOXIA
DER IFN BETA RESPONSE UP
TSAI DNAJB4 TARGETS UP
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP
HINATA NFKB TARGETS KERATINOCYTE UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
DER IFN GAMMA RESPONSE UP
WOTTON RUNX TARGETS UP
MAHADEVAN RESPONSE TO MP470 UP
NCI APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1
FERRARI RESPONSE TO FENRETINIDE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY
DAUER STAT3 TARGETS DN
ONDER CDH1 TARGETS 3 DN
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
MCLACHLAN DENTAL CARIES UP
MENSE HYPOXIA UPATF3, HK2, CEBPD, ADM, BHLHB2, SOD2, TIPARP
DAZARD UV RESPONSE CLUSTER G2
CHEN HOXA5 TARGETS 9HR UP
EINAV INTERFERON SIGNATURE IN CANCER
NCI CD40 PATHWAY
MCLACHLAN DENTAL CARIES DN
AMIT SERUM RESPONSE 40 MCF10A
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
BOWIE RESPONSE TO TAMOXIFEN
BROWNE HCMV INFECTION 4HR UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHU CMV 8 HR UP
ZHOU INFLAMMATORY RESPONSE LPS UP
SANA TNF SIGNALING UP
MOSERLE IFNA RESPONSE
FOSTER INFLAMMATORY RESPONSE LPS UP
XU HGF TARGETS INDUCED BY AKT1 6HR
LEE LIVER CANCER MYC E2F1 UP
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
VERHAAK AML WITH NPM1 MUTATED UP
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN MONOCYTE DN
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
XU HGF SIGNALING NOT VIA AKT1 48HR UP
ELVIDGE HYPOXIA BY DMOG UP
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
PRAMOONJAGO SOX4 TARGETS UP
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
mycobacterium tuberculosisbrucella neotomaehelicobacter pylori kx1 npgecGeneSet Name
0.00000 0.00269 0.00644NETPATH_IL_4_PATHWAY_DOWN
0.00019 0.05217 0.09166NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00602 0.00114 0.00201NETPATH_IL_1_PATHWAY_UP
0.00171 0.00000 0.05322NETPATH_IL_3_PATHWAY_UP
0.00000 0.01660 0.02074NETPATH_IL_6_PATHWAY_UP
0.00000 0.18522 0.04422GERY_CEBP_TARGETS
0.00010 0.09858 0.01817ST_TUMOR_NECROSIS_FACTOR_PATHWAY
0.00869 0.11441 0.00027NCI_NFKAPPABALTERNATIVEPATHWAY
0.00126 0.04130 0.14576NCI_IL23PATHWAY
0.00225 0.17773 0.06985KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00079 0.12949 0.08749CHEN_HOXA5_TARGETS_6HR_UP
0.00000 0.00128 0.09695OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00002 0.03682 0.18497GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.01105 0.16786 0.00008LEONARD_HYPOXIA
0.08229 0.00066 0.00667NETPATH_IL_9_PATHWAY_UP
0.00132 0.16767 0.00083MAHAJAN_RESPONSE_TO_IL1A_UP
0.00738 0.17788 0.04104BIOCARTA_EPONFKB_PATHWAY
0.00000 0.02415 0.00002ZHANG_INTERFERON_RESPONSE
0.02321 0.06507 0.07771KEGG_GRAFT_VERSUS_HOST_DISEASE
0.00000 0.00537 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.00000 0.02410 0.00011LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00814 0.10715 0.13965SA_MMP_CYTOKINE_CONNECTION
0.00000 0.00010 0.00003LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00000 0.14758 0.00052RADAEVA_RESPONSE_TO_IFNA1_UP
0.00052 0.04424 0.11617ELVIDGE_HYPOXIA_UP
0.00000 0.14453 0.00152KIM_LRRC3B_TARGETS
0.00000 0.01260 0.12195AMIT_EGF_RESPONSE_40_HELA
0.00000 0.17499 0.00059BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX
0.00008 0.02401 0.05966DORN_ADENOVIRUS_INFECTION_12HR_UP
0.00000 0.00665 0.09518MAHADEVAN_RESPONSE_TO_MP470_DN
0.00000 0.03804 0.00000UROSEVIC_RESPONSE_TO_IMIQUIMOD
0.00000 0.00715 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.00000 0.02175 0.00007TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP
0.00067 0.17495 0.08612HARRIS_HYPOXIA
0.00000 0.05335 0.00085DER_IFN_BETA_RESPONSE_UP
0.00004 0.16719 0.08948TSAI_DNAJB4_TARGETS_UP
0.00000 0.05608 0.02451DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP
0.00000 0.09086 0.00256HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00060 0.00378 0.06948KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.03927 0.12757BASSO_CD40_SIGNALING_UP
0.02521 0.01093 0.00009SOUCEK_MYC_TARGETS
0.00002 0.00644 0.05736DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.00214 0.06932DIRMEIER_LMP1_RESPONSE_EARLY
0.00000 0.08485 0.00454DER_IFN_GAMMA_RESPONSE_UP
0.00526 0.08266 0.19024WOTTON_RUNX_TARGETS_UP
0.00004 0.09849 0.00000MAHADEVAN_RESPONSE_TO_MP470_UP
0.08118 0.00390 0.00000NCI_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1
0.00018 0.02413 0.11271FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00176 0.00575 0.00000REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00000 0.00947 0.00051SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP
0.00000 0.07917 0.00000BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS
0.00002 0.09351 0.14476KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.11024 0.00003DAUER_STAT3_TARGETS_DN
0.10086 0.01819 0.06938ONDER_CDH1_TARGETS_3_DN
0.00000 0.00155 0.01934DAUER_STAT3_TARGETS_UP
0.00000 0.01035 0.00000LIANG_SILENCED_BY_METHYLATION_2
0.00000 0.03944 0.10968NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP
0.02002 0.19381 0.14559NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.00000 0.00479 0.02102MCLACHLAN_DENTAL_CARIES_UP
0.00000 0.06879 0.00732MENSE_HYPOXIA_UP
0.01541 0.00657 0.15355DAZARD_UV_RESPONSE_CLUSTER_G2
0.00006 0.02011 0.00899CHEN_HOXA5_TARGETS_9HR_UP
0.00000 0.10283 0.00000EINAV_INTERFERON_SIGNATURE_IN_CANCER
0.01575 0.16739 0.14335NCI_CD40_PATHWAY
0.00001 0.00595 0.06509MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.03264 0.13910AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00041 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00119 0.00000GAURNIER_PSMD4_TARGETS
0.00000 0.07552 0.00796GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.04685 0.00007BOWIE_RESPONSE_TO_TAMOXIFEN
0.00024 0.00980 0.06493BROWNE_HCMV_INFECTION_4HR_UP
0.00000 0.00387 0.00002ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00000 0.05292 0.00000ZHU_CMV_8_HR_UP
0.00000 0.02297 0.00001ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00058 0.00000SANA_TNF_SIGNALING_UP
0.00000 0.02846 0.00000MOSERLE_IFNA_RESPONSE
0.00000 0.09836 0.03879FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.00001 0.01539 0.01849XU_HGF_TARGETS_INDUCED_BY_AKT1_6HR
0.00022 0.14464 0.16806LEE_LIVER_CANCER_MYC_E2F1_UP
0.00000 0.00059 0.06147HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00000 0.03242 0.06454VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.19726 0.05694 0.09000TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINED_IN_MONOCYTE_DN
0.00000 0.01183 0.00002GEISS_RESPONSE_TO_DSRNA_UP
0.00059 0.00835 0.00515KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00000 0.00256 0.00603UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.00469 0.10373 0.18936XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_UP
0.00043 0.11243 0.06336ELVIDGE_HYPOXIA_BY_DMOG_UP
0.00000 0.05899 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.00000 0.00066 0.00201ZHU_CMV_ALL_UP
0.00000 0.05099 0.14588KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00002 0.00010 0.00039GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.00123 0.10013OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.13990 0.17189 0.18870LEE_LIVER_CANCER_HEPATOBLAST
0.00039 0.01371 0.02425ZUCCHI_METASTASIS_DN
0.00000 0.01336 0.01564NAGASHIMA_EGF_SIGNALING_UP
0.00000 0.10655 0.00004PRAMOONJAGO_SOX4_TARGETS_UP
0.00000 0.16797 0.15432PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN
0.00004 0.02489 0.04711AMIT_EGF_RESPONSE_60_MCF10A