BICLUSTER_ID : UPREG-310
PATHOGENS /3/ : listeria monocytogenes,fusobacterium nucleatum,streptococcus pneumoniae
TARGETS /2/ : PSMB2, PSMB1
Gene SetLeading Edge Genes
NCI VIF MEDIATED DEGRADATION OF APOBEC3GPSMB2, RBX1, PSMA1, PSMD14, UBA52, UBC, TCEB2, PSMA2, PSMB1, UBB, PSMA4, PSMB7, PSMB3, PSMA7
NCI APC C CDC20 MEDIATED DEGRADATION OF SECURINPSMA1, PSMD14, UBC, PSMA2, PSMB1, UBB, PSMA4, PSMB7, PSMB3, PSMA7
NCI APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1PSMA1, PSMD14, UBC, PSMA2, PSMB1, UBB, PSMA4, PSMB7, PSMB3, PSMA7
NCI AUTODEGRADATION OF CDH1 BY CDH1 APC CPSMA1, PSMD14, UBC, PSMA2, PSMB1, UBB, PSMA4, PSMB7, PSMB3, PSMA7
NCI UBIQUITIN DEPENDENT DEGRADATION OF CYCLIN D1PSMA1, PSMD14, UBC, PSMA2, PSMB1, UBB, PSMA4, PSMB7, PSMB3, PSMA7
NCI CDC20 PHOSPHO APC C MEDIATED DEGRADATION OF CYCLIN APSMA1, PSMD14, UBC, PSMA2, PSMB1, UBB, PSMA4, PSMB7, PSMB3, PSMA7
CORUM PA700-20S-PA28 COMPLEXPSMA1, PSMD14, PSMA2, PSMB1, PSMA4, PSMB7, PSMB3, PSMC2, PSMA7
NCI SCF BETA TRCP MEDIATED DEGRADATION OF EMI1PSMA1, PSMD14, UBC, PSMA2, PSMB1, UBB, PSMA4, PSMB7, PSMB3, PSMA7
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATION1PSMA1, PSMD14, UBC, PSMA2, PSMB1, UBB, PSMA4, PSMB7, PSMB3, PSMA7
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATIONPSMA1, PSMD14, UBC, PSMA2, PSMB1, UBB, PSMA4, PSMB7, PSMB3, PSMA7
NCI UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25APSMA1, PSMD14, UBC, PSMA2, PSMB1, UBB, PSMA4, PSMB7, PSMB3, PSMA7
NOJIMA SFRP2 TARGETS UP
GRADE METASTASIS DN
NCI FORMATION OF A POOL OF FREE 40S SUBUNITS
VANHARANTA UTERINE FIBROID DN
CHEN LVAD SUPPORT OF FAILING HEART UP
LY AGING OLD DN
NCI HOST INTERACTIONS OF HIV FACTORS
NATSUME RESPONSE TO INTERFERON BETA DN
NCI GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT
AMIT EGF RESPONSE 40 HELA
REACTOME METABOLISM OF PROTEINS
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN
CORUM PA28-20S PROTEASOME
MAHADEVAN RESPONSE TO MP470 DN
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21
NCI SCF SKP2 MEDIATED DEGRADATION OF P27 P21
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1
LI AMPLIFIED IN LUNG CANCER
TIEN INTESTINE PROBIOTICS 24HR DN
CORUM 40S RIBOSOMAL SUBUNIT CYTOPLASMIC
REACTOME INSULIN SYNTHESIS AND SECRETION
CORUM PA28GAMMA-20S PROTEASOME
REACTOME GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT
AMIT EGF RESPONSE 20 HELA
DAZARD UV RESPONSE CLUSTER G3
DACOSTA UV RESPONSE VIA ERCC3 DN
BILBAN B CLL LPL DN
DIRMEIER LMP1 RESPONSE EARLY
CORUM RIBOSOME CYTOPLASMICRPL10, RPL27, RPS11, RPL24, RPL38, RPS3A, RPS16, RPL32, RPL12, RPL14, RPS2, RPL39, RPL37, RPS20, RPL41, RPS15A, RPL4, RPS18, RPLP1, RPS4Y1, RPL23A, RPS10, RPS14, RPS21, RPS5, RPL13, RPS23, RPS19, RPS12, RPL30, FAU, RPS29, RPS13, RPL9, RPL19, RPL8, RPLP2, RPL15, RPL28, RPL31, RPS27, RPS24, RPS15
RASHI RESPONSE TO IONIZING RADIATION 1
NCI L13A MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION
NCI VPU MEDIATED DEGRADATION OF CD4
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN
REACTOME INFLUENZA LIFE CYCLE
SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP
REACTOME CDC20 PHOSPHO APC MEDIATED DEGRADATION OF CYCLIN A
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN 2FC DN
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS RED UP
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G
REACTOME ELECTRON TRANSPORT CHAIN
NCI CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6
REACTOME GENE EXPRESSION
MARTINEZ RESPONSE TO TRABECTEDIN UP
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE
REACTOME PEPTIDE CHAIN ELONGATION
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN
NCI VIRAL MRNA TRANSLATION
REACTOME VIRAL MRNA TRANSLATION
AMIT SERUM RESPONSE 40 MCF10A
REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS
REACTOME P53 INDEPENDENT DNA DAMAGE RESPONSE
NCI CAP DEPENDENT TRANSLATION INITIATION
DAZARD UV RESPONSE CLUSTER G24
REACTOME DIABETES PATHWAYS
NCI CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX
NCI EUKARYOTIC TRANSLATION TERMINATIONRPL10, RPL27, RPS11, RPL24, RPL38, RPS3A, RPS16, RPL32, RPL12, UBA52, RPL14, RPS2, RPL39, RPL37, RPS20, RPL41, RPS15A, RPL4, RPS18, RPLP1, RPL23A, RPS10, RPS14, RPS21, RPS5, RPL13, RPS23, RPS19, RPS12, RPL30, FAU, RPS29, RPS13, RPL9, RPL19, RPL8, RPLP2, RPL15, RPL28, RPL31, RPS27, RPS24, RPS15
NCI PEPTIDE CHAIN ELONGATIONRPL10, RPL27, RPS11, RPL24, RPL38, RPS3A, RPS16, RPL32, RPL12, EEF1A1, UBA52, RPL14, RPS2, RPL39, RPL37, RPS20, RPL41, RPS15A, RPL4, RPS18, RPL23A, RPLP1, RPS10, RPS14, RPS21, RPS5, RPL13, RPS23, RPS19, RPS12, RPL30, FAU, RPS29, RPS13, RPL9, RPL19, RPL8, RPLP2, RPL15, RPL28, RPL31, RPS27, RPS24, RPS15
NETPATH TNF ALPHA PATHWAY UP
HASLINGER B CLL WITH 13Q14 DELETION
FLOTHO PEDIATRIC ALL THERAPY RESPONSE UP
CORUM NOP56P-ASSOCIATED PRE-RRNA COMPLEX
GESERICK TERT TARGETS DN
NCI FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX
BROWNE HCMV INFECTION 2HR UP
CORUM 20S PROTEASOME
NCI REGULATION OF ORNITHINE DECARBOXYLASE ODC
CORUM 26S PROTEASOME
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE
REACTOME STABILIZATION OF P53
KEGG RIBOSOME
KIM WT1 TARGETS UP
ONDER CDH1 TARGETS 1 DN
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION
KEGG PROTEASOME
REACTOME FORMATION OF A POOL OF FREE 40S SUBUNITS
CORUM 60S RIBOSOMAL SUBUNIT CYTOPLASMIC
NCI SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE
NCI DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX
REACTOME TRANSLATION
HSIAO HOUSEKEEPING GENES
LEE EARLY T LYMPHOCYTE DN
KRIGE AMINO ACID DEPRIVATION
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
streptococcus pneumoniae g54listeria monocytogenesfusobacterium nucleatumGeneSet Name
0.03365 0.00069 0.00252NCI_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
0.04423 0.00482 0.00541NCI_APC_C_CDC20_MEDIATED_DEGRADATION_OF_SECURIN
0.04220 0.00178 0.04730NCI_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1
0.04350 0.00143 0.04367NCI_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C
0.04818 0.00081 0.00923NCI_UBIQUITIN_DEPENDENT_DEGRADATION_OF_CYCLIN_D1
0.02613 0.00272 0.00766NCI_CDC20_PHOSPHO_APC_C_MEDIATED_DEGRADATION_OF_CYCLIN_A
0.04807 0.00011 0.03471CORUM_PA700-20S-PA28_COMPLEX
0.03767 0.00045 0.00518NCI_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
0.04333 0.00062 0.00670NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION1
0.04796 0.00056 0.00225NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION
0.04458 0.00046 0.00176NCI_UBIQUITIN_MEDIATED_DEGRADATION_OF_PHOSPHORYLATED_CDC25A
0.17017 0.02668 0.07293NOJIMA_SFRP2_TARGETS_UP
0.08232 0.01744 0.15607GRADE_METASTASIS_DN
0.05058 0.00061 0.00000NCI_FORMATION_OF_A_POOL_OF_FREE_40S_SUBUNITS
0.00677 0.01117 0.19609VANHARANTA_UTERINE_FIBROID_DN
0.01145 0.06346 0.06956CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP
0.19137 0.09782 0.12099LY_AGING_OLD_DN
0.04816 0.00045 0.00122NCI_HOST_INTERACTIONS_OF_HIV_FACTORS
0.04185 0.00001 0.00000NATSUME_RESPONSE_TO_INTERFERON_BETA_DN
0.08582 0.00100 0.00000NCI_GTP_HYDROLYSIS_AND_JOINING_OF_THE_60S_RIBOSOMAL_SUBUNIT
0.02615 0.00068 0.03469AMIT_EGF_RESPONSE_40_HELA
0.11169 0.05098 0.00000REACTOME_METABOLISM_OF_PROTEINS
0.04993 0.00298 0.18992GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_DN
0.08304 0.00254 0.01729CORUM_PA28-20S_PROTEASOME
0.15502 0.01146 0.01422MAHADEVAN_RESPONSE_TO_MP470_DN
0.09247 0.00028 0.18100REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21
0.08690 0.00110 0.00283NCI_SCF_SKP2__MEDIATED_DEGRADATION_OF_P27_P21
0.05313 0.00013 0.09371REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
0.06990 0.01171 0.00533LI_AMPLIFIED_IN_LUNG_CANCER
0.00936 0.01129 0.05079TIEN_INTESTINE_PROBIOTICS_24HR_DN
0.08996 0.00200 0.00000CORUM_40S_RIBOSOMAL_SUBUNIT_CYTOPLASMIC
0.11824 0.01212 0.00000REACTOME_INSULIN_SYNTHESIS_AND_SECRETION
0.11893 0.00011 0.11452CORUM_PA28GAMMA-20S_PROTEASOME
0.08161 0.00127 0.00000REACTOME_GTP_HYDROLYSIS_AND_JOINING_OF_THE_60S_RIBOSOMAL_SUBUNIT
0.04591 0.02894 0.00393AMIT_EGF_RESPONSE_20_HELA
0.03860 0.00837 0.18846DAZARD_UV_RESPONSE_CLUSTER_G3
0.00135 0.03426 0.00000DACOSTA_UV_RESPONSE_VIA_ERCC3_DN
0.05066 0.01132 0.04894BILBAN_B_CLL_LPL_DN
0.08905 0.00199 0.01976DIRMEIER_LMP1_RESPONSE_EARLY
0.04216 0.00123 0.00000CORUM_RIBOSOME_CYTOPLASMIC
0.02099 0.01976 0.00226RASHI_RESPONSE_TO_IONIZING_RADIATION_1
0.09240 0.00108 0.00000NCI_L13A_MEDIATED_TRANSLATIONAL_SILENCING_OF_CERULOPLASMIN_EXPRESSION
0.07354 0.00119 0.00491NCI_VPU_MEDIATED_DEGRADATION_OF_CD4
0.00318 0.06466 0.00000DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN
0.05064 0.01149 0.00000REACTOME_INFLUENZA_LIFE_CYCLE
0.16929 0.01108 0.11682SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_UP
0.03006 0.00091 0.05726REACTOME_CDC20_PHOSPHO_APC_MEDIATED_DEGRADATION_OF_CYCLIN_A
0.02410 0.17670 0.17468SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_2FC_DN
0.09080 0.02791 0.17013GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_RED_UP
0.05320 0.00069 0.03536REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
0.02389 0.14708 0.00004REACTOME_ELECTRON_TRANSPORT_CHAIN
0.15941 0.00070 0.00676NCI_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6
0.11279 0.10317 0.09484REACTOME_GENE_EXPRESSION
0.05063 0.00555 0.01715MARTINEZ_RESPONSE_TO_TRABECTEDIN_UP
0.03041 0.01078 0.12433SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE
0.04336 0.00119 0.00000REACTOME_PEPTIDE_CHAIN_ELONGATION
0.04093 0.00306 0.07677PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN
0.06641 0.00228 0.00000NCI_VIRAL_MRNA_TRANSLATION
0.06578 0.00240 0.00000REACTOME_VIRAL_MRNA_TRANSLATION
0.00737 0.00799 0.00145AMIT_SERUM_RESPONSE_40_MCF10A
0.11162 0.00196 0.00000REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS
0.05824 0.00031 0.02476REACTOME_P53_INDEPENDENT_DNA_DAMAGE_RESPONSE
0.09055 0.00088 0.00000NCI_CAP_DEPENDENT_TRANSLATION_INITIATION
0.03319 0.06503 0.09159DAZARD_UV_RESPONSE_CLUSTER_G24
0.08527 0.13973 0.00000REACTOME_DIABETES_PATHWAYS
0.15800 0.01511 0.04098NCI_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX
0.04420 0.00064 0.00000NCI_EUKARYOTIC_TRANSLATION_TERMINATION
0.04545 0.00108 0.00000NCI_PEPTIDE_CHAIN_ELONGATION
0.07319 0.00123 0.01710NETPATH_TNF_ALPHA_PATHWAY_UP
0.13661 0.09666 0.16085HASLINGER_B_CLL_WITH_13Q14_DELETION
0.12998 0.14664 0.02078FLOTHO_PEDIATRIC_ALL_THERAPY_RESPONSE_UP
0.14129 0.04083 0.00000CORUM_NOP56P-ASSOCIATED_PRE-RRNA_COMPLEX
0.00310 0.02216 0.04180GESERICK_TERT_TARGETS_DN
0.09037 0.00130 0.00000NCI_FORMATION_OF_THE_TERNARY_COMPLEX__AND_SUBSEQUENTLY__THE_43S_COMPLEX
0.09115 0.00140 0.00000REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX
0.04469 0.02059 0.08625BROWNE_HCMV_INFECTION_2HR_UP
0.11176 0.00025 0.03508CORUM_20S_PROTEASOME
0.05117 0.00061 0.06082NCI_REGULATION_OF_ORNITHINE_DECARBOXYLASE__ODC_
0.07300 0.00002 0.01436CORUM_26S_PROTEASOME
0.11131 0.00069 0.08069REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE
0.13021 0.00163 0.12783REACTOME_STABILIZATION_OF_P53
0.05727 0.00580 0.00000KEGG_RIBOSOME
0.00273 0.01564 0.00000KIM_WT1_TARGETS_UP
0.07758 0.00003 0.00000ONDER_CDH1_TARGETS_1_DN
0.00000 0.00007 0.04380UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.06029 0.01407 0.00000REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION
0.05741 0.00038 0.03071KEGG_PROTEASOME
0.04813 0.00078 0.00000REACTOME_FORMATION_OF_A_POOL_OF_FREE_40S_SUBUNITS
0.08629 0.03740 0.00000CORUM_60S_RIBOSOMAL_SUBUNIT_CYTOPLASMIC
0.09866 0.01012 0.01332NCI_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE
0.05961 0.00037 0.00680NCI_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX
0.08208 0.00878 0.00000REACTOME_TRANSLATION
0.03670 0.00245 0.00000HSIAO_HOUSEKEEPING_GENES
0.06967 0.11840 0.18064LEE_EARLY_T_LYMPHOCYTE_DN
0.04467 0.15378 0.02874KRIGE_AMINO_ACID_DEPRIVATION