BICLUSTER_ID : UPREG-312
PATHOGENS /3/ : brucella ovis,shigella dysenteriae,brucella melitensis
TARGETS /17/ : VDR, LDHB, PDE4B, LDLR, CCL2, TNFRSF1B, PPIA, UGCG, RDH5, NFKB1, IFNB1, IL6, IL1B, PTGS2, NGFB, PLAUR, TNF
Gene SetLeading Edge Genes
NETPATH TNF ALPHA PATHWAY UPVDR, RPL38, HBEGF, NFKBIA, PTGES, PDLIM4, INHBA, UGCG, CXCL2, SOD2, RDH5, NFKB1, HMGN2, CSF1, JUNB, BCL3, S100A4, CKS2, IFITM3, TNFAIP2, IL1B, TNFAIP3, NFKBIB, NFKB2, LDLR, CCL2, PSMA5, TMSB10, PPIA, TNFRSF1B, TRAF1, IFIT2, PTX3, IER3, HBXIP, TNFSF7, BIRC3, RPL7A, CD5, TRIM21, ADAM17, CXADR, ETS2, IFNB1, IL6, PTGS2, SRP19, NGFB, ZFP36, PLAUR
NETPATH IL 2 PATHWAY UPLDHB, PDE4B, LDLR, EIF1, TNFRSF1B, SOCS3, CCL4, IER3, IFIT1, NFKB1, TRIM21, NFIL3, IDI1, IL1B, DAXX, MYC, PLAUR, TNF
NETPATH IL 5 PATHWAY UPNFKB1, NFKBIB, BIRC3, PDE4B, NFKB2, CCL2, HBEGF, NFIL3, IL1B, IDI1, IER3
NETPATH IL 1 PATHWAY UPCCL2, HBEGF, NFKBIA, SOD3, PTGES, MT2A, CXCL2, SOD2, CCL4, NFKB1, BIRC3, SULT4A1, CHI3L1, DCN, PTGS2, IL1B, MYC, PIP5K1A
NETPATH IL 3 PATHWAY UPSOCS3, IL1B, CCL2, MYC, CCL4, TNF
ST TUMOR NECROSIS FACTOR PATHWAYNFKB1, NFKBIA, NFKBIB, BIRC3, NFKB2, TNFRSF1B, TNF
NETPATH IL 1 PATHWAYNFKB1, NFKBIA, NFKBIB, IL1B
NETPATH KIT RECEPTOR PATHWAY UPSNAI1, JUNB, CCL2, MYC, TNF, IER3
NETPATH IL 6 PATHWAY UPSOCS3, GADD45B, CEBPD, LDLR, JUNB, HBEGF, TNF
NETPATH EGFR1 PATHWAY UPSNAI1, PHLDA1, HBEGF, EHD1, PTGS2, SLC20A1, MYC, PLAUR, IER3
NETPATH IL 9 PATHWAY UPSOCS3, CCL2, JUNB, MYC
NCI PROSTANOID HORMONESPTGS2
NCI CD40 PATHWAYTRAF1, NFKB1, NFKBIA, BIRC3, MYC
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
BIOCARTA IL10 PATHWAY
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
SCIAN CELL CYCLE TARGETS OF TP53 AND TP73 DN
BIOCARTA NFKB PATHWAY
DORN ADENOVIRUS INFECTION 32HR DN
SESTO RESPONSE TO UV C1
CROONQUIST STROMAL STIMULATION UP
LINDSTEDT DENDRITIC CELL MATURATION B
LY AGING OLD DN
BIOCARTA IL1R PATHWAY
SA MMP CYTOKINE CONNECTION
BIOCARTA RELA PATHWAY
LINDSTEDT DENDRITIC CELL MATURATION A
SIMBULAN UV RESPONSE NORMAL UP
NETPATH IL 4 PATHWAY DOWN
NETPATH IL 7 PATHWAY UPCXCL2, MYC, CCL4
MISHRA CARCINOMA ASSOCIATED FIBROBLAST UP
DORN ADENOVIRUS INFECTION 12HR UP
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
BUDHU LIVER CANCER METASTASIS DN
HINATA NFKB TARGETS KERATINOCYTE UP
SEIKE LUNG CANCER POOR SURVIVAL
DORN ADENOVIRUS INFECTION 48HR DN
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
MARZEC IL2 SIGNALING UP
SOUCEK MYC TARGETS
GILMORE CORE NFKB PATHWAY
DUTTA APOPTOSIS VIA NFKB
COULOUARN TEMPORAL TGFB1 SIGNATURE UP
DIRMEIER LMP1 RESPONSE EARLY
CORUM 12S U11 SNRNPYBX1
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
BIOCARTA TID PATHWAY
BILD HRAS ONCOGENIC SIGNATURE
ZHOU INFLAMMATORY RESPONSE LIVE UP
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
KEGG LEISHMANIA INFECTION
DAZARD RESPONSE TO UV NHEK UP
MCLACHLAN DENTAL CARIES UP
DAZARD UV RESPONSE CLUSTER G2
MARKS HDAC TARGETS DN
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 40 MCF10A
GAURNIER PSMD4 TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHOU INFLAMMATORY RESPONSE LPS UP
NCI IL23PATHWAY
SANA TNF SIGNALING UP
AMIT SERUM RESPONSE 120 MCF10A
BERENJENO TRANSFORMED BY RHOA UP
DORN ADENOVIRUS INFECTION 24HR DN
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
KIM WT1 TARGETS UP
VERHAAK AML WITH NPM1 MUTATED UP
LY AGING MIDDLE DN
GEISS RESPONSE TO DSRNA UP
ONDER CDH1 TARGETS 1 DN
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
XU HGF SIGNALING NOT VIA AKT1 6HR
BIOCARTA GRANULOCYTES PATHWAY
BIOCARTA TNFR2 PATHWAY
ZHOU INFLAMMATORY RESPONSE FIMA UP
AMIT EGF RESPONSE 120 MCF10A
TIAN TNF SIGNALING VIA NFKB
LY AGING PREMATURE DN
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
CROONQUIST NRAS VS STROMAL STIMULATION DN
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
NAGASHIMA EGF SIGNALING UP
HOFMANN MYELODYSPLASTIC SYNDROM LOW RISK DN
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
brucella melitensisbrucella ovisshigella dysenteriaeGeneSet Name
0.09797 0.15651 0.07626NETPATH_TNF_ALPHA_PATHWAY_UP
0.03203 0.18663 0.08636NETPATH_IL_2_PATHWAY_UP
0.01177 0.03173 0.00014NETPATH_IL_5_PATHWAY_UP
0.00061 0.01452 0.00030NETPATH_IL_1_PATHWAY_UP
0.00052 0.00156 0.00147NETPATH_IL_3_PATHWAY_UP
0.00659 0.06146 0.01233ST_TUMOR_NECROSIS_FACTOR_PATHWAY
0.02567 0.08064 0.02164NETPATH_IL_1_PATHWAY
0.02966 0.17580 0.00112NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00163 0.01065 0.00000NETPATH_IL_6_PATHWAY_UP
0.16175 0.19976 0.00148NETPATH_EGFR1_PATHWAY_UP
0.00000 0.00706 0.05058NETPATH_IL_9_PATHWAY_UP
0.06807 0.16934 0.06968NCI_PROSTANOID_HORMONES
0.18357 0.14332 0.00073NCI_CD40_PATHWAY
0.00628 0.01964 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.15511 0.16352 0.19139BIOCARTA_IL10_PATHWAY
0.03113 0.07308 0.00252GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.05245 0.04770 0.05679SCIAN_CELL_CYCLE_TARGETS_OF_TP53_AND_TP73_DN
0.00822 0.12428 0.01398BIOCARTA_NFKB_PATHWAY
0.00667 0.03181 0.00014DORN_ADENOVIRUS_INFECTION_32HR_DN
0.05889 0.12145 0.19068SESTO_RESPONSE_TO_UV_C1
0.07941 0.01979 0.00808CROONQUIST_STROMAL_STIMULATION_UP
0.01411 0.02851 0.00053LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.05192 0.01382 0.00183LY_AGING_OLD_DN
0.01663 0.03199 0.00825BIOCARTA_IL1R_PATHWAY
0.04554 0.18285 0.10485SA_MMP_CYTOKINE_CONNECTION
0.04753 0.15619 0.08410BIOCARTA_RELA_PATHWAY
0.00644 0.00044 0.00034LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.02965 0.05634 0.03162SIMBULAN_UV_RESPONSE_NORMAL_UP
0.00471 0.00062 0.16501NETPATH_IL_4_PATHWAY_DOWN
0.02550 0.01316 0.04120NETPATH_IL_7_PATHWAY_UP
0.16708 0.15429 0.00016MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_UP
0.01408 0.03636 0.00527DORN_ADENOVIRUS_INFECTION_12HR_UP
0.00944 0.06140 0.00000THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.02838 0.08131 0.10833BUDHU_LIVER_CANCER_METASTASIS_DN
0.05127 0.03817 0.00078HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.03691 0.05722 0.08149SEIKE_LUNG_CANCER_POOR_SURVIVAL
0.02820 0.09920 0.00056DORN_ADENOVIRUS_INFECTION_48HR_DN
0.03717 0.05857 0.00096KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.04270 0.08843 0.00004BASSO_CD40_SIGNALING_UP
0.01700 0.05261 0.00321MARZEC_IL2_SIGNALING_UP
0.00824 0.00716 0.02047SOUCEK_MYC_TARGETS
0.01568 0.18747 0.02153GILMORE_CORE_NFKB_PATHWAY
0.00246 0.01264 0.02611DUTTA_APOPTOSIS_VIA_NFKB
0.03253 0.08879 0.14473COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP
0.00015 0.01330 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.16287 0.15765 0.07130CORUM_12S_U11_SNRNP
0.02236 0.05049 0.17156REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.09531 0.16728 0.02606BIOCARTA_TID_PATHWAY
0.15734 0.06372 0.00000BILD_HRAS_ONCOGENIC_SIGNATURE
0.00487 0.00746 0.00006ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00563 0.10980 0.00005DAUER_STAT3_TARGETS_UP
0.18585 0.03860 0.00396LIANG_SILENCED_BY_METHYLATION_2
0.01414 0.13650 0.00317KEGG_LEISHMANIA_INFECTION
0.10000 0.12521 0.00111DAZARD_RESPONSE_TO_UV_NHEK_UP
0.01108 0.03202 0.01598MCLACHLAN_DENTAL_CARIES_UP
0.06885 0.14937 0.00032DAZARD_UV_RESPONSE_CLUSTER_G2
0.01578 0.14666 0.08234MARKS_HDAC_TARGETS_DN
0.00031 0.01159 0.00236FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.01946 0.04417 0.02949MCLACHLAN_DENTAL_CARIES_DN
0.00010 0.00076 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.19786 0.08142 0.00000AMIT_SERUM_RESPONSE_40_MCF10A
0.00642 0.00581 0.04466GAURNIER_PSMD4_TARGETS
0.02218 0.05672 0.00003GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00017 0.00055 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.02743 0.04278 0.03754ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.03782 0.05836 0.09953NCI_IL23PATHWAY
0.00362 0.01931 0.00530SANA_TNF_SIGNALING_UP
0.00478 0.01293 0.00021AMIT_SERUM_RESPONSE_120_MCF10A
0.01394 0.18363 0.12456BERENJENO_TRANSFORMED_BY_RHOA_UP
0.02672 0.12363 0.00042DORN_ADENOVIRUS_INFECTION_24HR_DN
0.00468 0.00038 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.04719 0.12374 0.00000SESTO_RESPONSE_TO_UV_C3
0.10192 0.09311 0.00000KIM_WT1_TARGETS_UP
0.01897 0.08159 0.00095VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.13545 0.08810 0.16015LY_AGING_MIDDLE_DN
0.09792 0.08028 0.01687GEISS_RESPONSE_TO_DSRNA_UP
0.09382 0.11964 0.09552ONDER_CDH1_TARGETS_1_DN
0.05866 0.01384 0.00000UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.05877 0.04999 0.00031XU_HGF_SIGNALING_NOT_VIA_AKT1_6HR
0.00520 0.05900 0.18726BIOCARTA_GRANULOCYTES_PATHWAY
0.18375 0.12499 0.00110BIOCARTA_TNFR2_PATHWAY
0.00643 0.01646 0.01029ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP
0.03700 0.12289 0.02002AMIT_EGF_RESPONSE_120_MCF10A
0.00659 0.02617 0.00005TIAN_TNF_SIGNALING_VIA_NFKB
0.02662 0.06144 0.00075LY_AGING_PREMATURE_DN
0.07780 0.05898 0.00000KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS
0.00050 0.00040 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.14119 0.14029 0.02426CROONQUIST_NRAS_VS_STROMAL_STIMULATION_DN
0.00613 0.01906 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.04602 0.15857 0.00154LEE_LIVER_CANCER_HEPATOBLAST
0.04193 0.19801 0.00000NAGASHIMA_EGF_SIGNALING_UP
0.06751 0.18479 0.04537HOFMANN_MYELODYSPLASTIC_SYNDROM_LOW_RISK_DN
0.15037 0.16302 0.00153HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.02006 0.03197 0.00000AMIT_EGF_RESPONSE_60_MCF10A