| Gene Set | Leading Edge Genes |
|---|
| NETPATH TNF ALPHA PATHWAY UP | HDGF, RPL10, RPS11, SCG3, GPX4, STX10, DYRK4, MRPL12, XKR8, NFKBIA, PDLIM4, RPL12, HADH2, TOLLIP, NDUFS6, PDE9A, INPP5E, ENG, IER2, EXTL1, NDUFA13, RPS18, TMSB10, PPIA, RABAC1, DEXI, CCL23, RPS12, FAU, PPP1R15A, RPL19, CACNG3, SLC29A2, ZBTB5, NDUFB6, SF3B2, SLC30A3, COX8A, COX7C, ZFP36, GAL3ST1, SPAG8, RAPGEF5, QSCN6, PSMB8, ATP5G2, SLC39A1, ERG, EMP3, S100A6, IFITM1, TMED1, BPI, FGF3, IFITM3, COMMD4, IRF1, RPL41, CRABP2, NFKBIE, TCEB2, TNFRSF1B, CCDC52, PARK7, GMFG, RPS5, KIAA0141, RPL30, RPL7A, LTB, PIGR, COX7A2, PHKG1, RPLP2, PRDX1, HINT1, SPR, NME1, RPL27, RPL38, OPTN, MT1E, RPS6, PMAIP1, TARBP2, SHH, RPS16, RPL18, RPL22, NDUFB7, PSMB5, EIF3S4, APRT, SILV, CTSF, ATF4, ABCA7, CSTB, KLRA1, CAPG, CLIC1, EVPL, DCTN3, GRIK1, RPS10, TMEM147, PDCD5, RPS23, RPS19, S100A11, PTTG1, MYL6, GSTP1, SUV39H1, NAPG, SMYD3, DUSP1, HMGB2, FXYD1, UQCRH, S100A13, TAGLN2, GRIA2, VHL, EGR1, NDUFA7, ECM1, PSME1, ATP5G1, BCL3, FXR2, UBE2C, GNG11, SELE, RAB13, EBP, RPS15A, ALOX12B, RPL23A, FOLH1, TIMM17B, NEDD8, PRDX2, MT1H, NDUFB3, KIAA0672, FAM50A, H2AFV, RPL31, NGFB, PSMB3, SNRPD2, RPS15 |
| MOOTHA VOXPHOS | NDUFA3, ATP5G2, UQCRH, ATP5H, UQCRFS1, NDUFS8, NDUFA7, SDHC, UQCRC1, NDUFB7, ATP5O, NDUFS6, ATP5G1, ATP5J2, NDUFS2, ATP5E, NDUFAB1, NDUFS3, NDUFC1, ATP5C1, NDUFS7, ATP5D, COX5B, NDUFA2, NDUFB3, NDUFA9, COX7A2, COX6A1, NDUFA4, NDUFB6, ATP5G3, COX7C, ATP5B, ATP5L |
| CORUM RESPIRATORY CHAIN COMPLEX I HOLOENZYME MITOCHONDRIAL | NDUFA13, NDUFA3, NDUFS7, NDUFV1, NDUFA1, NDUFS8, NDUFA7, NDUFA2, NDUFB3, NDUFB7, NDUFS6, NDUFA9, NDUFA4, NDUFB6, NDUFS2, NDUFAB1, NDUFS3, NDUFB11, NDUFC1 |
| CORUM RESPIRATORY CHAIN COMPLEX I LAMBDA SUBUNIT MITOCHONDRIAL | NDUFA13, NDUFS6, NDUFS7, NDUFA7, NDUFS8, NDUFA2, NDUFV1 |
| CORUM RESPIRATORY CHAIN COMPLEX I BETA SUBUNIT MITOCHONDRIAL | NDUFA4, NDUFB3, NDUFB6, NDUFB7, NDUFAB1, NDUFB11 |
| NCI HOST INTERACTIONS OF HIV FACTORS | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI ORC1 REMOVAL FROM CHROMATIN | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, MCM5, UBC, PSMD13, ORC3L, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI SCF SKP2 MEDIATED DEGRADATION OF P27 P21 | PSMB2, CKS1B, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI VPU MEDIATED DEGRADATION OF CD4 | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATION1 | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI VIF MEDIATED DEGRADATION OF APOBEC3G | RBX1, PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, TCEB2, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEX | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI REMOVAL OF LICENSING FACTORS FROM ORIGINS | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI UBIQUITIN DEPENDENT DEGRADATION OF CYCLIN D1 | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI SWITCHING OF ORIGINS TO A POST REPLICATIVE STATE | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATION | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| NCI UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A | PSMB2, PSMC5, PSMB5, PSMB8, UBA52, UBC, PSMD13, PSMB6, PSMB9, UBB, PSMD4, PSMB3, PSMF1, PSME1 |
| CORUM F1F0-ATP SYNTHASE EC 3.6.3.14 MITOCHONDRIAL | ATP5O, ATP5C1, ATP5D, ATP5G1, ATP5J2, ATP5E, ATP5H, ATP5B, ATP5L |
| NETPATH IL 3 PATHWAY DOWN | SRC, FOS, TNFRSF1B |
| NCI ATF2 PATHWAY | DDIT3, GADD45A, PDGFRA, PPARGC1A, ATF3, IL23A, FOS, DUSP1 |
| NCI FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | ATP5O, ATP5C1, ATP5D, ATP5G1, ATP5J2, ATP5E, ATP5H, ATP5B, ATP5L |
| LOPEZ MESOTELIOMA SURVIVAL TIME UP | |
| NATSUME RESPONSE TO INTERFERON BETA DN | |
| WONG MITOCHONDRIA GENE MODULE | |
| NCI GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT | RPL10, RPL27, RPS11, RPL24, RPL38, RPS17, RPS6, RPL23, RPS16, RPLP0, RPL18, RPL22, RPL32, RPL12, UBA52, RPL39, RPS4X, RPS2, RPL5, RPL37, RPL13A, RPL36, RPL41, RPS3, RPL3, RPS15A, RPL35, RPL4, RPS18, RPLP1, RPL23A, RPS10, RPS14, RPS21, RPS5, RPL13, RPS23, RPL11, RPS19, RPS12, RPL30, FAU, RPL7A, RPL19, RPL9, RPS13, RPS29, RPL8, RPLP2, RPL35A, RPL31, RPL7, RPS24, RPS15 |
| CORUM CDC2-PCNA-CCNB1-GADD45B COMPLEX | GADD45B |
| AMIT EGF RESPONSE 40 HELA | |
| REACTOME GLUCOSE REGULATION OF INSULIN SECRETION | |
| REACTOME METABOLISM OF PROTEINS | |
| MISHRA CARCINOMA ASSOCIATED FIBROBLAST UP | |
| CHAUHAN RESPONSE TO METHOXYESTRADIOL DN | |
| ALCALA APOPTOSIS | |
| NCI DNA REPAIR | UBB, UBA52, UBC |
| LI AMPLIFIED IN LUNG CANCER | |
| REACTOME INSULIN SYNTHESIS AND SECRETION | |
| DAZARD UV RESPONSE CLUSTER G3 | |
| WILLIAMS ESR2 TARGETS DN | |
| DIRMEIER LMP1 RESPONSE EARLY | |
| CORUM RIBOSOME CYTOPLASMIC | RPL10, RPL27, RPS11, RPL24, RPL38, RPS17, RPS6, RPL23, RPS16, RPLP0, RPL18, RPL22, RPL32, RPL12, RPL39, RPS4X, RPS2, RPL5, RPL37, RPL13A, RPL17, RPL36, RPL41, RPS3, RPL3, RPS15A, RPL35, RPL4, RPS18, RPS4Y1, RPLP1, RPL23A, RPS10, RPS14, RPS21, RPS5, RPL13, RPS23, RPL11, RPS19, RPS12, RPL30, FAU, RPL7A, RPL19, RPL9, RPS13, RPS29, RPL8, RPLP2, RPL35A, RPL31, RPL7, RPS24, RPS15 |
| DAZARD UV RESPONSE CLUSTER G4 | |
| KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION | |
| TAKAO RESPONSE TO UVB RADIATION UP | |
| REACTOME INFLUENZA LIFE CYCLE | |
| NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP | |
| SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP | |
| CORUM TRBP CONTAINING COMPLEX DICER RPL7A EIF6 MOV10 AND SUBUNITS OF THE 60S RIBOSOMAL PARTICLE | RPL30, RPL27, RPL7A, RPLP1, RPL19, RPLP2, RPL35A, RPL32, RPL7, RPL36, RPL12, RPL13, RPL11 |
| NCI TRANSLATION INITIATION COMPLEX FORMATION | RPS15A, RPS11, RPS18, RPS17, RPS10, RPS14, RPS21, RPS16, RPS23, RPS19, RPS12, FAU, RPS13, RPS29, RPS4X, RPS2, RPS24, RPS15 |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN 2FC DN | |
| REACTOME ELECTRON TRANSPORT CHAIN | |
| KEGG GLYCOLYSIS GLUCONEOGENESIS | |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 | |
| KEGG OXIDATIVE PHOSPHORYLATION | |
| KEGG CARDIAC MUSCLE CONTRACTION | |
| DIRMEIER LMP1 RESPONSE LATE DN | |
| REACTOME INTEGRATION OF ENERGY METABOLISM | |
| NCI VIRAL MRNA TRANSLATION | RPL10, RPL27, RPS11, RPL24, RPL38, RPS17, RPS6, RPL23, RPS16, RPLP0, RPL18, RPL22, RPL32, RPL12, UBA52, RPL39, RPS4X, RPS2, RPL5, RPL37, RPL13A, RPL36, RPL41, RPS3, RPL3, RPS15A, RPL35, RPL4, RPS18, RPLP1, RPL23A, RPS10, RPS14, RPS21, RPS5, RPL13, RPS23, RPL11, RPS19, RPS12, RPL30, FAU, RPL7A, RPL9, RPL19, RPS13, RPS29, RPL8, RPLP2, RPL35A, RPL31, RPL7, RPS24, RPS15 |
| REACTOME VIRAL MRNA TRANSLATION | |
| KEGG GALACTOSE METABOLISM | |
| REACTOME P53 INDEPENDENT DNA DAMAGE RESPONSE | |
| REACTOME DIABETES PATHWAYS | |
| NCI EUKARYOTIC TRANSLATION TERMINATION | RPL10, RPL27, RPS11, RPL24, RPL38, RPS17, RPS6, RPL23, RPS16, RPLP0, RPL18, RPL22, RPL32, RPL12, UBA52, RPL39, RPS4X, RPS2, RPL5, RPL37, RPL13A, RPL36, RPL41, RPS3, RPL3, RPS15A, RPL35, RPL4, RPS18, RPLP1, RPL23A, RPS10, RPS14, RPS21, RPS5, RPL13, RPS23, RPL11, RPS19, RPS12, RPL30, FAU, RPL7A, RPL9, RPL19, RPS13, RPS29, RPL8, RPLP2, RPL35A, RPL31, RPL7, RPS24, RPS15 |
| NCI PEPTIDE CHAIN ELONGATION | RPL10, RPL27, RPS11, RPL24, RPL38, RPS17, RPS6, RPL23, RPS16, RPLP0, RPL18, RPL22, RPL32, RPL12, EEF1A1, UBA52, RPL39, RPS2, RPS4X, RPL5, RPL37, RPL13A, RPL36, RPL41, RPS3, RPL3, RPS15A, RPL35, RPL4, RPS18, RPLP1, RPL23A, RPS10, RPS14, RPS21, RPS5, RPL13, RPS23, RPL11, RPS19, RPS12, RPL30, FAU, RPL7A, RPL19, RPL9, RPS13, RPS29, RPL8, RPLP2, RPL35A, RPL31, RPL7, RPS24, RPS15 |
| BIOCARTA AHSP PATHWAY | |
| NCI FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | RPS15A, RPS11, RPS18, RPS17, RPS10, RPS14, RPS21, RPS16, RPS23, RPS19, RPS12, FAU, RPS13, RPS29, RPS4X, RPS2, RPS24, RPS15 |
| BROWNE HCMV INFECTION 2HR UP | |
| REACTOME REGULATION OF INSULIN SECRETION | |
| KEGG RIBOSOME | |
| YANAGISAWA LUNG CANCER RECURRENCE | |
| BARRIER CANCER RELAPSE TUMOR SAMPLE DN | |
| CHANDRAN METASTASIS TOP50 DN | |
| NCI RIBOSOMAL SCANNING AND START CODON RECOGNITION | RPS15A, RPS11, RPS18, RPS17, RPS10, RPS14, RPS21, RPS16, RPS23, RPS19, RPS12, FAU, RPS13, RPS29, RPS4X, RPS2, RPS24, RPS15 |
| KEGG ALZHEIMERS DISEASE | |
| CHASSOT SKIN WOUND | |
| REACTOME GLUCONEOGENESIS | |
| KEGG PROTEASOME | |
| KRIGE AMINO ACID DEPRIVATION | |
| HEDENFALK BREAST CANCER BRACX UP | |
| NOJIMA SFRP2 TARGETS UP | |
| GRADE COLON CANCER UP | |
| NCI FORMATION OF A POOL OF FREE 40S SUBUNITS | RPL10, RPL27, RPS11, RPL24, RPL38, RPS17, RPS6, RPL23, RPS16, RPLP0, RPL18, RPL22, RPL32, RPL12, UBA52, RPL39, RPS4X, RPS2, RPL5, RPL37, RPL13A, RPL36, RPL41, RPS3, RPL3, RPS15A, RPL35, RPL4, RPS18, RPLP1, RPL23A, RPS10, RPS14, RPS21, RPS5, RPL13, RPS23, RPL11, RPS19, RPS12, RPL30, FAU, RPL7A, RPL9, RPL19, RPS13, RPS29, RPL8, RPLP2, RPL35A, RPL31, RPL7, RPS24, RPS15 |
| GRADE METASTASIS DN | |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | |
| NCI REGULATION OF DNA REPLICATION | UBB, UBA52, UBC |
| MODY HIPPOCAMPUS POSTNATAL | |
| MAHADEVAN RESPONSE TO MP470 DN | |
| CONCANNON APOPTOSIS BY EPOXOMICIN DN | |
| REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | |
| CORUM 40S RIBOSOMAL SUBUNIT CYTOPLASMIC | RPS15A, RPS11, RPS18, RPS17, RPS10, RPS14, RPS21, RPS16, RPS23, RPS19, RPS12, FAU, RPS13, RPS29, RPS4X, RPS2, RPS24, RPS15 |
| REACTOME GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT | |
| AMIT EGF RESPONSE 20 HELA | |
| ENK UV RESPONSE KERATINOCYTE UP | |
| WEST ADRENOCORTICAL TUMOR MARKERS DN | |
| DACOSTA UV RESPONSE VIA ERCC3 DN | |
| REACTOME TRANSLATION INITIATION COMPLEX FORMATION | |
| SESTO RESPONSE TO UV C6 | |
| RASHI RESPONSE TO IONIZING RADIATION 1 | |
| NCI L13A MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION | RPL10, RPL27, RPS11, RPL24, RPL38, RPS17, RPS6, RPL23, RPS16, RPLP0, RPL18, RPL22, RPL32, RPL12, UBA52, RPL39, RPS4X, RPS2, RPL5, RPL37, RPL13A, RPL36, RPL41, RPS3, RPL3, RPS15A, RPL35, RPL4, RPS18, RPLP1, RPL23A, RPS10, RPS14, RPS21, RPS5, RPL13, RPS23, RPL11, RPS19, RPS12, RPL30, FAU, RPL7A, RPL19, RPL9, RPS13, RPS29, RPL8, RPLP2, RPL35A, RPL31, RPL7, RPS24, RPS15 |
| DACOSTA UV RESPONSE VIA ERCC3 COMMON DN | |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP | |
| JAZAG TGFB1 SIGNALING VIA SMAD4 UP | |
| REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | |
| MARTINEZ RESPONSE TO TRABECTEDIN UP | |
| LEE LIVER CANCER ACOX1 UP | |
| KEGG PARKINSONS DISEASE | |
| REACTOME PEPTIDE CHAIN ELONGATION | |
| ABE INNER EAR | |
| PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN | |
| KEGG HUNTINGTONS DISEASE | |
| GNATENKO PLATELET SIGNATURE | |
| AMIT SERUM RESPONSE 40 MCF10A | |
| REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | |
| NCI CAP DEPENDENT TRANSLATION INITIATION | RPL10, RPL27, RPS11, RPL24, RPL38, RPS17, RPS6, RPL23, RPS16, RPLP0, RPL18, RPL22, RPL32, RPL12, UBA52, RPL39, RPS4X, RPS2, RPL5, RPL37, RPL13A, RPL36, RPL41, RPS3, RPL3, RPS15A, RPL35, RPL4, RPS18, RPLP1, RPL23A, RPS10, RPS14, RPS21, RPS5, RPL13, RPS23, RPL11, RPS19, RPS12, RPL30, FAU, RPL7A, RPL19, RPL9, RPS13, RPS29, RPL8, RPLP2, RPL35A, RPL31, RPL7, RPS24, RPS15 |
| DAIRKEE TERT TARGETS UP | |
| CORUM NOP56P-ASSOCIATED PRE-RRNA COMPLEX | RPL10, RPL27, RPS11, RPL24, RPS17, YBX1, RPS6, RPL23, RPS16, RPLP0, RPL18, RPL22, RPL32, RPL12, EEF1A1, RPS2, RPL39, RPL5, RPL13A, RPL17, RPL36, RPL3, RPS15A, RPL35, RPL4, RPS18, RPLP1, RPL23A, RPS14, RPS23, RPL13, RPL11, RPS12, RPL30, RPL7A, RPL19, RPL9, RPS13, RPS29, RPL8, RPLP2, RPL35A, RPL31, RPL7, RPS24, RPS15 |
| POMEROY MEDULLOBLASTOMA PROGNOSIS DN | |
| REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | |
| RODWELL AGING KIDNEY UP | |
| KEGG DRUG METABOLISM CYTOCHROME P450 | |
| HU ANGIOGENESIS UP | |
| ONDER CDH1 TARGETS 1 DN | |
| UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN | |
| TIMOFEEVA GROWTH STRESS VIA STAT1 DN | |
| REACTOME REGULATION OF BETA CELL DEVELOPMENT | |
| TARTE PLASMA CELL VS PLASMABLAST UP | |
| REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | |
| CHNG MULTIPLE MYELOMA HYPERPLOID UP | |
| REACTOME FORMATION OF A POOL OF FREE 40S SUBUNITS | |
| NIKOLSKY BREAST CANCER 16P13 AMPLICON | |
| CORUM 60S RIBOSOMAL SUBUNIT CYTOPLASMIC | RPL10, RPL27, RPL24, RPL38, RPLP0, RPL23, RPL18, RPL22, RPL32, RPL12, RPL39, RPL5, RPL37, RPL13A, RPL36, RPL17, RPL41, RPL3, RPL35, RPL4, RPLP1, RPL23A, RPL13, RPL11, RPL30, RPL7A, RPL19, RPL9, RPL8, RPLP2, RPL31, RPL35A, RPL7 |
| REACTOME TRANSLATION | |
| RICKMAN HEAD AND NECK CANCER E | |
| REACTOME GLUCOSE METABOLISM | |
| HSIAO HOUSEKEEPING GENES | |
| NCI FANCONI ANEMIA PATHWAY | UBB, UBA52, UBC, VCP |