BICLUSTER_ID : UPREG-330
PATHOGENS /3/ : bacillus anthracis,escherichia coli,burkholderia pseudomallei
TARGETS /9/ : NFKB1, CCL20, CCL2, ACSL1, IL1B, PTGS2, ICAM1, SAT1, IL8
Gene SetLeading Edge Genes
NETPATH IL 4 PATHWAY DOWNPDGFB, CCL20, LITAF, IL7R, CCL2, NFKBIA, PTGS2, ICAM1, NINJ1, IL8, CXCL2
GERY CEBP TARGETSCXCL1, ACSL1, GADD45G, TNFAIP6, SAT1, BTG2, PTX3, DUSP1
SA MMP CYTOKINE CONNECTIONIL1B
NETPATH IL 7 PATHWAY UPCXCL3, CXCL1, LITAF, IL8, CXCL2, CCL4
NCI REGULATED PROTEOLYSIS OF P75NTRNFKB1, ADAM17
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
NOJIMA SFRP2 TARGETS UP
CHEN HOXA5 TARGETS 6HR UP
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
MAHAJAN RESPONSE TO IL1A UP
BIOCARTA EPONFKB PATHWAY
VANHARANTA UTERINE FIBROID DN
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS
AUJLA IL22 AND IL17A SIGNALING
DORN ADENOVIRUS INFECTION 32HR DN
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
CROONQUIST STROMAL STIMULATION UP
HALMOS CEBPA TARGETS UP
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
ZHANG RESPONSE TO CANTHARIDIN UP
AMIT EGF RESPONSE 40 HELA
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5
MAHADEVAN RESPONSE TO MP470 DN
JEON SMAD6 TARGETS UP
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
LU TUMOR ANGIOGENESIS UP
KEGG PRION DISEASES
HARRIS HYPOXIA
HINATA NFKB TARGETS KERATINOCYTE UP
BIOCARTA CYTOKINE PATHWAY
SEIKE LUNG CANCER POOR SURVIVAL
DORN ADENOVIRUS INFECTION 48HR DN
AMIT EGF RESPONSE 20 HELA
TIAN TNF SIGNALING NOT VIA NFKB
VART KSHV INFECTION ANGIOGENIC MARKERS UP
AMIT SERUM RESPONSE 60 MCF10A
NAGASHIMA NRG1 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
MAHADEVAN RESPONSE TO MP470 UP
FERRARI RESPONSE TO FENRETINIDE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
BILD HRAS ONCOGENIC SIGNATURE
ZHOU INFLAMMATORY RESPONSE LIVE UP
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP
ONDER CDH1 TARGETS 3 DN
AMIT EGF RESPONSE 120 HELA
DAUER STAT3 TARGETS UP
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS
REACTOME NF KB IS ACTIVATED AND SIGNALS SURVIVAL
AMIT EGF RESPONSE 60 HELA
DAZARD UV RESPONSE CLUSTER G2
LEE SP4 THYMOCYTE
TAVOR CEBPA TARGETS UP
SEKI INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 40 MCF10A
OSAWA TNF TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
GESERICK TERT TARGETS DN
CLASPER LYMPHATIC VESSELS DURING METASTASIS UP
BROWNE HCMV INFECTION 2HR UP
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
KIM WT1 TARGETS UP
VERHAAK AML WITH NPM1 MUTATED UP
GEISS RESPONSE TO DSRNA UP
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
KOBAYASHI EGFR SIGNALING 6HR DN
BIOCARTA TNFR2 PATHWAY
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE DN
REACTOME VIRAL DSRNA TLR3 TRIF COMPLEX ACTIVATES RIP1
ZHOU INFLAMMATORY RESPONSE FIMA UP
HESS TARGETS OF HOXA9 AND MEIS1 DN
AMIT EGF RESPONSE 120 MCF10A
REACTOME GPCR LIGAND BINDING
TIAN TNF SIGNALING VIA NFKB
MURAKAMI UV RESPONSE 1HR DN
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
NAGASHIMA EGF SIGNALING UP
AMIT DELAYED EARLY GENES
PRAMOONJAGO SOX4 TARGETS UP
WATTEL AUTONOMOUS THYROID ADENOMA DN
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
burkholderia pseudomalleibacillus anthracisescherichia coliGeneSet Name
0.16712 0.12825 0.00000NETPATH_IL_4_PATHWAY_DOWN
0.00015 0.01488 0.01389GERY_CEBP_TARGETS
0.13793 0.15130 0.00133SA_MMP_CYTOKINE_CONNECTION
0.16021 0.04896 0.00000NETPATH_IL_7_PATHWAY_UP
0.04305 0.04700 0.01182NCI_REGULATED_PROTEOLYSIS_OF_P75NTR
0.02392 0.00020 0.00000KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00000 0.00004 0.00018NOJIMA_SFRP2_TARGETS_UP
0.01125 0.04547 0.13852CHEN_HOXA5_TARGETS_6HR_UP
0.00964 0.06111 0.00000MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.01050 0.01784 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00002 0.15911 0.00000GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.01913 0.01475 0.00000MAHAJAN_RESPONSE_TO_IL1A_UP
0.19387 0.07439 0.00507BIOCARTA_EPONFKB_PATHWAY
0.10491 0.13063 0.00612VANHARANTA_UTERINE_FIBROID_DN
0.09854 0.06042 0.00121REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
0.14966 0.19473 0.00129AUJLA_IL22_AND_IL17A_SIGNALING
0.19819 0.05861 0.00003DORN_ADENOVIRUS_INFECTION_32HR_DN
0.05958 0.14368 0.00015REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.02367 0.03531 0.00003CROONQUIST_STROMAL_STIMULATION_UP
0.11122 0.00725 0.00001HALMOS_CEBPA_TARGETS_UP
0.16626 0.00554 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00750 0.00000 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.16617 0.12238 0.09441ZHANG_RESPONSE_TO_CANTHARIDIN_UP
0.00290 0.00021 0.00000AMIT_EGF_RESPONSE_40_HELA
0.03172 0.02634 0.03327YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5
0.00025 0.19442 0.00317MAHADEVAN_RESPONSE_TO_MP470_DN
0.01183 0.12103 0.00031JEON_SMAD6_TARGETS_UP
0.12979 0.00240 0.00000THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.07323 0.19021 0.01099LU_TUMOR_ANGIOGENESIS_UP
0.04980 0.13100 0.10959KEGG_PRION_DISEASES
0.16949 0.07884 0.00034HARRIS_HYPOXIA
0.00143 0.00000 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.13358 0.00101 0.00002BIOCARTA_CYTOKINE_PATHWAY
0.10886 0.00417 0.00018SEIKE_LUNG_CANCER_POOR_SURVIVAL
0.14963 0.18980 0.00089DORN_ADENOVIRUS_INFECTION_48HR_DN
0.02388 0.14256 0.00089AMIT_EGF_RESPONSE_20_HELA
0.00280 0.08646 0.00702TIAN_TNF_SIGNALING_NOT_VIA_NFKB
0.07425 0.00675 0.00000VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP
0.00292 0.17556 0.00109AMIT_SERUM_RESPONSE_60_MCF10A
0.00002 0.00590 0.00000NAGASHIMA_NRG1_SIGNALING_UP
0.03675 0.00345 0.00037SOUCEK_MYC_TARGETS
0.07914 0.01600 0.00000DUTTA_APOPTOSIS_VIA_NFKB
0.04849 0.00000 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.14983 0.00593 0.00000MAHADEVAN_RESPONSE_TO_MP470_UP
0.05896 0.01068 0.00016FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.10469 0.00253 0.00000REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.01123 0.13675 0.00000BILD_HRAS_ONCOGENIC_SIGNATURE
0.00909 0.00000 0.00000ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00000 0.02051 0.00155GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP
0.05647 0.00403 0.00000ONDER_CDH1_TARGETS_3_DN
0.00027 0.08697 0.00046AMIT_EGF_RESPONSE_120_HELA
0.00256 0.00062 0.00003DAUER_STAT3_TARGETS_UP
0.09145 0.01448 0.00004HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS
0.07309 0.02143 0.00247REACTOME_NF_KB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL
0.02574 0.18300 0.00523AMIT_EGF_RESPONSE_60_HELA
0.02586 0.15429 0.00004DAZARD_UV_RESPONSE_CLUSTER_G2
0.02590 0.17154 0.05781LEE_SP4_THYMOCYTE
0.08082 0.17277 0.00020TAVOR_CEBPA_TARGETS_UP
0.01261 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.06818 0.00325 0.00142AMIT_SERUM_RESPONSE_40_MCF10A
0.03652 0.01929 0.00142OSAWA_TNF_TARGETS
0.00000 0.00009 0.00000GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00139 0.00000 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00623 0.00454 0.00083GESERICK_TERT_TARGETS_DN
0.02356 0.19719 0.03242CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_UP
0.05164 0.00022 0.00014BROWNE_HCMV_INFECTION_2HR_UP
0.00000 0.00029 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00000 0.00327 0.00001SESTO_RESPONSE_TO_UV_C3
0.05021 0.11950 0.00002KIM_WT1_TARGETS_UP
0.13600 0.00551 0.00000VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.11502 0.03512 0.00000GEISS_RESPONSE_TO_DSRNA_UP
0.00019 0.00003 0.00044UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.01348 0.00025 0.00015KOBAYASHI_EGFR_SIGNALING_6HR_DN
0.06700 0.00304 0.00004BIOCARTA_TNFR2_PATHWAY
0.00000 0.00000 0.00000GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_DN
0.12038 0.06111 0.00018REACTOME_VIRAL_DSRNA_TLR3_TRIF_COMPLEX_ACTIVATES_RIP1
0.00000 0.00000 0.00000ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP
0.08705 0.13442 0.08966HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.05040 0.14343 0.00004AMIT_EGF_RESPONSE_120_MCF10A
0.14924 0.08594 0.00318REACTOME_GPCR_LIGAND_BINDING
0.00000 0.00000 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.11119 0.19523 0.17260MURAKAMI_UV_RESPONSE_1HR_DN
0.00000 0.00000 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.02880 0.01781 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00000 0.00009 0.00003NAGASHIMA_EGF_SIGNALING_UP
0.00501 0.13027 0.00082AMIT_DELAYED_EARLY_GENES
0.01688 0.08362 0.00005PRAMOONJAGO_SOX4_TARGETS_UP
0.19540 0.03664 0.02507WATTEL_AUTONOMOUS_THYROID_ADENOMA_DN
0.03538 0.00000 0.00000HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00375 0.00559 0.00000AMIT_EGF_RESPONSE_60_MCF10A