BICLUSTER_ID : UPREG-334
PATHOGENS /3/ : brucella neotomae,bacillus anthracis,brucella ovis
TARGETS /13/ : NFKB1, PDE4B, CCL8, CCL2, LTB, CD80, IL6, PTGS2, IL1B, CCL5, PIM1, IL2RA, TNF
Gene SetLeading Edge Genes
NETPATH IL 5 PATHWAY UPNFKB1, BIRC3, PDE4B, NFKB2, CCL2, LTB, IL1A, IL1B, IL2RA, PIM1, IER3
NETPATH IL 1 PATHWAY UPNFKB1, CSF3, BIRC3, CCL2, CCL8, CKS2, CCL7, NFKBIA, IL6, SOD3, PTGS2, IL1B, CXCL2, CSF2, CCL4
NETPATH KIT RECEPTOR PATHWAY UPJUNB, CCL2, IL6, SOCS1, CCL5, PIM1, CSF2, IER3, TNF
NETPATH IL 4 PATHWAY DOWNNFKBIA, GADD45B, PTGS2, CCL2, LTB, CXCL2, TNF
NETPATH IL 7 PATHWAY UPCCL8, CCL5, CXCL2, IL2RA, CD80, CCL4
NETPATH IL 3 PATHWAY UPCCL7, IL1B, CCL2, PIM1, CCL4, TNF
NCI IL23PATHWAYNFKB1, NFKBIA, IL1B, TNF
SA MMP CYTOKINE CONNECTIONIL1B, TNF
NETPATH IL 1 PATHWAYNFKB1, NFKBIA, IL1B
NCI NFKAPPABALTERNATIVEPATHWAYNFKB1, NFKB2
NCI PROSTANOID HORMONESPTGS2
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
BIOCARTA NFKB PATHWAY
MAHAJAN RESPONSE TO IL1A UP
BIOCARTA EPONFKB PATHWAY
KEGG GRAFT VERSUS HOST DISEASE
DORN ADENOVIRUS INFECTION 32HR DN
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
CROONQUIST STROMAL STIMULATION UP
LINDSTEDT DENDRITIC CELL MATURATION B
BIOCARTA IL1R PATHWAY
BIOCARTA RELA PATHWAY
LINDSTEDT DENDRITIC CELL MATURATION A
REACTOME PHASE 1 FUNCTIONALIZATION OF COMPOUNDS
SIMBULAN UV RESPONSE NORMAL UP
MAHADEVAN RESPONSE TO MP470 DN
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
BROWNE INTERFERON RESPONSIVE GENES
BUDHU LIVER CANCER METASTASIS DN
DIRMEIER LMP1 RESPONSE LATE UP
HINATA NFKB TARGETS KERATINOCYTE UP
DORN ADENOVIRUS INFECTION 48HR DN
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
AMIT SERUM RESPONSE 60 MCF10A
MARZEC IL2 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
FERRARI RESPONSE TO FENRETINIDE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
BIOCARTA TID PATHWAY
ZHOU INFLAMMATORY RESPONSE LIVE UP
ONDER CDH1 TARGETS 3 DN
AMIT EGF RESPONSE 120 HELA
BIOCARTA ERYTH PATHWAY
DAUER STAT3 TARGETS UP
DAZARD RESPONSE TO UV NHEK UP
MCLACHLAN DENTAL CARIES UP
DAZARD UV RESPONSE CLUSTER G2
MARKS HDAC TARGETS DN
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
KEGG ALLOGRAFT REJECTION
SEKI INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 40 MCF10A
GAURNIER PSMD4 TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHOU INFLAMMATORY RESPONSE LPS UP
SMID BREAST CANCER LUMINAL B DN
SANA TNF SIGNALING UP
FOSTER INFLAMMATORY RESPONSE LPS UP
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
KIM WT1 TARGETS UP
VERHAAK AML WITH NPM1 MUTATED UP
GEISS RESPONSE TO DSRNA UP
ONDER CDH1 TARGETS 1 DN
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE DN
ZHOU INFLAMMATORY RESPONSE FIMA UP
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
NETPATH IL 2 PATHWAY UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN
AMIT EGF RESPONSE 60 MCF10A
GRAHAM CML DIVIDING VS NORMAL DIVIDING DN
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
bacillus anthracisbrucella ovisbrucella neotomaeGeneSet Name
0.00652 0.03173 0.12369NETPATH_IL_5_PATHWAY_UP
0.00738 0.01452 0.00114NETPATH_IL_1_PATHWAY_UP
0.01116 0.17580 0.05217NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.12825 0.00062 0.00269NETPATH_IL_4_PATHWAY_DOWN
0.04896 0.01316 0.01290NETPATH_IL_7_PATHWAY_UP
0.19023 0.00156 0.00000NETPATH_IL_3_PATHWAY_UP
0.00010 0.05836 0.04130NCI_IL23PATHWAY
0.15130 0.18285 0.10715SA_MMP_CYTOKINE_CONNECTION
0.15756 0.08064 0.10960NETPATH_IL_1_PATHWAY
0.12358 0.08826 0.11441NCI_NFKAPPABALTERNATIVEPATHWAY
0.10488 0.16934 0.07832NCI_PROSTANOID_HORMONES
0.00020 0.03342 0.17773KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.01784 0.01964 0.00128OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.15911 0.07308 0.03682GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.09838 0.12428 0.17568BIOCARTA_NFKB_PATHWAY
0.01475 0.08148 0.16767MAHAJAN_RESPONSE_TO_IL1A_UP
0.07439 0.11461 0.17788BIOCARTA_EPONFKB_PATHWAY
0.03120 0.01234 0.06507KEGG_GRAFT_VERSUS_HOST_DISEASE
0.05861 0.03181 0.06343DORN_ADENOVIRUS_INFECTION_32HR_DN
0.00986 0.03248 0.00537ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.14368 0.12412 0.11314REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.03531 0.01979 0.00132CROONQUIST_STROMAL_STIMULATION_UP
0.00000 0.02851 0.02410LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00016 0.03199 0.07069BIOCARTA_IL1R_PATHWAY
0.08726 0.15619 0.04814BIOCARTA_RELA_PATHWAY
0.00000 0.00044 0.00010LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.19528 0.03801 0.07172REACTOME_PHASE_1_FUNCTIONALIZATION_OF_COMPOUNDS
0.13030 0.05634 0.01104SIMBULAN_UV_RESPONSE_NORMAL_UP
0.19442 0.06080 0.00665MAHADEVAN_RESPONSE_TO_MP470_DN
0.00240 0.06140 0.01038THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.15574 0.12548 0.00715BROWNE_INTERFERON_RESPONSIVE_GENES
0.00779 0.08131 0.16089BUDHU_LIVER_CANCER_METASTASIS_DN
0.04511 0.03254 0.16770DIRMEIER_LMP1_RESPONSE_LATE_UP
0.00000 0.03817 0.09086HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.18980 0.09920 0.11822DORN_ADENOVIRUS_INFECTION_48HR_DN
0.00215 0.05857 0.00378KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.08843 0.03927BASSO_CD40_SIGNALING_UP
0.17556 0.11740 0.11766AMIT_SERUM_RESPONSE_60_MCF10A
0.05995 0.05261 0.08610MARZEC_IL2_SIGNALING_UP
0.00345 0.00716 0.01093SOUCEK_MYC_TARGETS
0.01600 0.01264 0.00644DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.01330 0.00214DIRMEIER_LMP1_RESPONSE_EARLY
0.01068 0.08101 0.02413FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00253 0.05049 0.00575REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.01740 0.16728 0.16198BIOCARTA_TID_PATHWAY
0.00000 0.00746 0.01309ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00403 0.00115 0.01819ONDER_CDH1_TARGETS_3_DN
0.08697 0.12378 0.02726AMIT_EGF_RESPONSE_120_HELA
0.00047 0.01221 0.16720BIOCARTA_ERYTH_PATHWAY
0.00062 0.10980 0.00155DAUER_STAT3_TARGETS_UP
0.15309 0.12521 0.11484DAZARD_RESPONSE_TO_UV_NHEK_UP
0.11704 0.03202 0.00479MCLACHLAN_DENTAL_CARIES_UP
0.15429 0.14937 0.00657DAZARD_UV_RESPONSE_CLUSTER_G2
0.19813 0.14666 0.06194MARKS_HDAC_TARGETS_DN
0.09653 0.01159 0.00621FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.12968 0.04417 0.00595MCLACHLAN_DENTAL_CARIES_DN
0.03072 0.13146 0.14303KEGG_ALLOGRAFT_REJECTION
0.00000 0.00076 0.00041SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00325 0.08142 0.03264AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00581 0.00119GAURNIER_PSMD4_TARGETS
0.00009 0.05672 0.07552GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00055 0.00387ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00000 0.04278 0.02297ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.02727 0.19116 0.18528SMID_BREAST_CANCER_LUMINAL_B_DN
0.00096 0.01931 0.00058SANA_TNF_SIGNALING_UP
0.19461 0.08922 0.09836FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.00029 0.00038 0.00059HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00327 0.12374 0.04591SESTO_RESPONSE_TO_UV_C3
0.11950 0.09311 0.10627KIM_WT1_TARGETS_UP
0.00551 0.08159 0.03242VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.03512 0.08028 0.01183GEISS_RESPONSE_TO_DSRNA_UP
0.19846 0.11964 0.17331ONDER_CDH1_TARGETS_1_DN
0.02609 0.03178 0.00835KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00003 0.01384 0.00256UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.00000 0.19809 0.10986GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_DN
0.00000 0.01646 0.05928ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP
0.00000 0.02617 0.05899TIAN_TNF_SIGNALING_VIA_NFKB
0.14821 0.06104 0.00066ZHU_CMV_ALL_UP
0.18345 0.18663 0.17779NETPATH_IL_2_PATHWAY_UP
0.15813 0.13418 0.05099KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00040 0.00010GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.01781 0.01906 0.00123OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00308 0.15857 0.17189LEE_LIVER_CANCER_HEPATOBLAST
0.00000 0.10002 0.01371ZUCCHI_METASTASIS_DN
0.00009 0.19801 0.01336NAGASHIMA_EGF_SIGNALING_UP
0.14385 0.05093 0.15401CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN
0.00559 0.03197 0.02489AMIT_EGF_RESPONSE_60_MCF10A
0.18354 0.14653 0.15801GRAHAM_CML_DIVIDING_VS_NORMAL_DIVIDING_DN