BICLUSTER_ID : UPREG-342
PATHOGENS /3/ : pseudomonas aeruginosa,bifidobacterium bifidum,aeromonas caviae
TARGETS /9/ : MTHFR, LCN2, LCK, JUN, CD40, HCK, IL1B, PIM1, GZMB
Gene SetLeading Edge Genes
NETPATH IL 9 PATHWAY UPSOCS3, LCN2, CCL3, PIM1, BCL3, GZMB
NETPATH IL 2 PATHWAY UPPFKFB3, LCK, STAT5A, NMI, SOCS3, IL4R, CCL3, IL1B, SOCS1, IRF1, UPP1, GZMB, MX1
NCI IL6 7PATHWAYSOCS3, JUN, TIMP1, IRF1, HCK
NCI CD40 PATHWAYBIRC3, JUN, TRAF3, CD40, STAT5A, BIRC2, TRAF1, TNFAIP3, TRAF6
NETPATH IL 4 PATHWAY UPMTHFR, JUN, IBRDC3, BCL3, CH25H, SOCS3, IL4R, PDZK1IP1, IL1RN, SOCS1, INHBA
NETPATH IL 3 PATHWAY UPSOCS3, IL1B, SOCS1
NETPATH IL 6 PATHWAY UPCXCL1, JUN, BCL3, MAP3K8, SOCS3, SOCS1, ZFP36, IRF1
NCI IL23PATHWAYSOCS3, IL1B, CXCL1, STAT5A
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
MAHAJAN RESPONSE TO IL1A UP
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER
AUJLA IL22 AND IL17A SIGNALING
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
LINDSTEDT DENDRITIC CELL MATURATION B
SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN
LINDSTEDT DENDRITIC CELL MATURATION A
WALLACE PROSTATE CANCER RACE UP
KIM LRRC3B TARGETS
HORIUCHI WTAP TARGETS UP
NETPATH IL 4 PATHWAY DOWNIRF1
NETPATH IL 7 PATHWAY UPCXCL5, CXCL1, STAT5A
BIOCARTA NKT PATHWAY
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 DN
BROWNE INTERFERON RESPONSIVE GENES
KEGG JAK STAT SIGNALING PATHWAY
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP
REACTOME SIGNALING IN IMMUNE SYSTEM
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN
HINATA NFKB TARGETS KERATINOCYTE UP
TIEN INTESTINE PROBIOTICS 24HR UP
GALI TP53 TARGETS APOPTOTIC UP
MARKEY RB1 ACUTE LOF UP
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
BIOCARTA BLYMPHOCYTE PATHWAY
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
DER IFN GAMMA RESPONSE UP
MAHADEVAN RESPONSE TO MP470 UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP
KEGG LEISHMANIA INFECTION
LIAN LIPA TARGETS 6M
MCLACHLAN DENTAL CARIES UP
ISHIKAWA STING SIGNALING
NETPATH IL 5 PATHWAY UPBIRC3, CCL3
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
HELLER SILENCED BY METHYLATION UP
FARMER BREAST CANCER CLUSTER 1
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHU CMV 8 HR UP
ZHOU INFLAMMATORY RESPONSE LPS UP
SMID BREAST CANCER LUMINAL B DN
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP
BOQUEST STEM CELL CULTURED VS FRESH DN
SANA TNF SIGNALING UP
LEE LIVER CANCER MYC E2F1 UP
ODONNELL TARGETS OF MYC AND TFRC UP
CASTELLANO NRAS TARGETS UP
VERHAAK AML WITH NPM1 MUTATED UP
LIAN LIPA TARGETS 3M
KEGG CHEMOKINE SIGNALING PATHWAY
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1
BIOCARTA GRANULOCYTES PATHWAY
CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX RPL6 RPL30 RPS13 CHUK DDX3X NFKB2 NFKBIB REL IKBKG NFKB1 MAP3K8 RELB GLG1 NFKBIA RELA TNIP2 GTF2I
ST TUMOR NECROSIS FACTOR PATHWAYBIRC3, BIRC2
HESS TARGETS OF HOXA9 AND MEIS1 DN
HUMMEL BURKITTS LYMPHOMA DN
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
bifidobacterium bifidumpseudomonas aeruginosaaeromonas caviaGeneSet Name
0.00572 0.06627 0.07320NETPATH_IL_9_PATHWAY_UP
0.07512 0.11013 0.07215NETPATH_IL_2_PATHWAY_UP
0.08284 0.09153 0.07318NCI_IL6_7PATHWAY
0.01529 0.00075 0.06428NCI_CD40_PATHWAY
0.05727 0.08967 0.03395NETPATH_IL_4_PATHWAY_UP
0.01084 0.01596 0.00216NETPATH_IL_3_PATHWAY_UP
0.00007 0.01244 0.10211NETPATH_IL_6_PATHWAY_UP
0.00000 0.00049 0.00704NCI_IL23PATHWAY
0.00000 0.00066 0.01697KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00214 0.01558 0.01924GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00474 0.00000 0.16652MAHAJAN_RESPONSE_TO_IL1A_UP
0.03039 0.09845 0.05653SATO_SILENCED_EPIGENETICALLY_IN_PANCREATIC_CANCER
0.00419 0.04032 0.01459AUJLA_IL22_AND_IL17A_SIGNALING
0.00000 0.00016 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.01762 0.00095 0.13954REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.00000 0.00005 0.00053LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00360 0.13870 0.05537SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_DN
0.00005 0.00387 0.00124LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00167 0.03564 0.00000WALLACE_PROSTATE_CANCER_RACE_UP
0.00007 0.03852 0.00000KIM_LRRC3B_TARGETS
0.00296 0.10214 0.12653HORIUCHI_WTAP_TARGETS_UP
0.00103 0.00000 0.01190NETPATH_IL_4_PATHWAY_DOWN
0.01764 0.00151 0.16616NETPATH_IL_7_PATHWAY_UP
0.03302 0.03928 0.18798BIOCARTA_NKT_PATHWAY
0.11419 0.06176 0.00603CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN
0.00000 0.10336 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.00000 0.19708 0.00316KEGG_JAK_STAT_SIGNALING_PATHWAY
0.00139 0.13363 0.16527TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP
0.15636 0.04260 0.00615REACTOME_SIGNALING_IN_IMMUNE_SYSTEM
0.05738 0.14826 0.13231TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN
0.00013 0.00000 0.06206HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00000 0.00000 0.00000TIEN_INTESTINE_PROBIOTICS_24HR_UP
0.03207 0.06810 0.05625GALI_TP53_TARGETS_APOPTOTIC_UP
0.00000 0.02176 0.00000MARKEY_RB1_ACUTE_LOF_UP
0.00006 0.00006 0.00110BASSO_CD40_SIGNALING_UP
0.00012 0.00251 0.00169SOUCEK_MYC_TARGETS
0.04026 0.13404 0.04205BIOCARTA_BLYMPHOCYTE_PATHWAY
0.00215 0.00086 0.05340DUTTA_APOPTOSIS_VIA_NFKB
0.00294 0.00000 0.00564DIRMEIER_LMP1_RESPONSE_EARLY
0.00551 0.01592 0.00005DER_IFN_GAMMA_RESPONSE_UP
0.00318 0.00009 0.00240MAHADEVAN_RESPONSE_TO_MP470_UP
0.00006 0.00003 0.00008REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00015 0.00026 0.10841KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.18711 0.16256 0.00000FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP
0.00011 0.00006 0.05120DAUER_STAT3_TARGETS_UP
0.00000 0.00126 0.00001LIANG_SILENCED_BY_METHYLATION_2
0.13644 0.01171 0.00001NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP
0.00573 0.00366 0.05933KEGG_LEISHMANIA_INFECTION
0.04912 0.14139 0.01871LIAN_LIPA_TARGETS_6M
0.00155 0.00000 0.00003MCLACHLAN_DENTAL_CARIES_UP
0.11417 0.10531 0.00242ISHIKAWA_STING_SIGNALING
0.11144 0.00238 0.07327NETPATH_IL_5_PATHWAY_UP
0.00000 0.00185 0.00001FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00444 0.00005 0.00003MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00002SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00007 0.00036 0.00001GAURNIER_PSMD4_TARGETS
0.02743 0.17408 0.00206HELLER_SILENCED_BY_METHYLATION_UP
0.00019 0.03450 0.00001FARMER_BREAST_CANCER_CLUSTER_1
0.00000 0.00000 0.00001ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00006 0.02114 0.00058ZHU_CMV_8_HR_UP
0.00000 0.00043 0.01590ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.13028 0.04524 0.08643SMID_BREAST_CANCER_LUMINAL_B_DN
0.00865 0.00725 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP
0.17193 0.18974 0.16593BOQUEST_STEM_CELL_CULTURED_VS_FRESH_DN
0.00000 0.00000 0.00000SANA_TNF_SIGNALING_UP
0.02392 0.16348 0.01790LEE_LIVER_CANCER_MYC_E2F1_UP
0.10487 0.02044 0.13045ODONNELL_TARGETS_OF_MYC_AND_TFRC_UP
0.00034 0.13383 0.02086CASTELLANO_NRAS_TARGETS_UP
0.02011 0.00267 0.08932VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.05374 0.12753 0.04935LIAN_LIPA_TARGETS_3M
0.10844 0.02579 0.01801KEGG_CHEMOKINE_SIGNALING_PATHWAY
0.00426 0.00051 0.00364GEISS_RESPONSE_TO_DSRNA_UP
0.00006 0.00006 0.00700KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00145 0.02559 0.00399GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN
0.14936 0.00537 0.08380SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1
0.01849 0.04859 0.04491BIOCARTA_GRANULOCYTES_PATHWAY
0.09338 0.00376 0.14885CORUM_TNF-ALPHA/NF-KAPPA_B_SIGNALING_COMPLEX_RPL6_RPL30_RPS13_CHUK_DDX3X_NFKB2_NFKBIB_REL_IKBKG_NFKB1_MAP3K8_RELB_GLG1_NFKBIA_RELA_TNIP2__GTF2I
0.00028 0.00000 0.11624ST_TUMOR_NECROSIS_FACTOR_PATHWAY
0.09533 0.15886 0.01035HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.06060 0.00598 0.11042HUMMEL_BURKITTS_LYMPHOMA_DN
0.03180 0.13854 0.14609ZHU_CMV_ALL_UP
0.00000 0.00027 0.00443KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00000 0.09323GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.11780 0.00340 0.00108BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP