BICLUSTER_ID : UPREG-346
PATHOGENS /4/ : aeromonas caviae,mycobacterium tuberculosis,shigella dysenteriae,ehrlichia chaffeensis
TARGETS /7/ : IL2RG, JUN, JAK2, IL1B, ICAM1, CCL8, TNFRSF1B
Gene SetLeading Edge Genes
NETPATH IL 2 PATHWAY UPIFIT1, PFKFB3, KLF6, CSF1, TNFSF10, TNFRSF1B, CCR1, TRIM21, IL2RG, IL1B, ICAM1, FOS, CCL4
NCI IL6 7PATHWAYPRKCD, JAK2, JUN, GAB2, IRF1, FOS
NETPATH IL 3 PATHWAY UPIL1B, CSF1, FOS, CCL4
NETPATH IL 6 PATHWAY UPCXCL1, JUN, FOS, MAP3K8, PRDM1
NETPATH IL 5 PATHWAY UPBIRC3, NFKBIE, CCR1, LCP2, ICAM1, RELB, PRDM1, MYD88, EGR2, CASP4
NETPATH IL 4 PATHWAY UPFGL2, MXD1, JUN, FOS, EGR2
NETPATH IL 7 PATHWAY UPCXCL1, CCL8, CCL4
ST TUMOR NECROSIS FACTOR PATHWAYNFKBIA, BIRC3, NFKBIE, TNFRSF1B
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
NETPATH IL 9 PATHWAY UP
MAHAJAN RESPONSE TO IL1A UP
CHEN LVAD SUPPORT OF FAILING HEART DN
KEGG LEISHMANIA INFECTION
MCLACHLAN DENTAL CARIES UP
RUTELLA RESPONSE TO HGF DN
VARELA ZMPSTE24 TARGETS UP
BOYAULT LIVER CANCER SUBCLASS G5 DN
TENEDINI MEGAKARYOCYTE MARKERS
LINDSTEDT DENDRITIC CELL MATURATION B
BECKER TAMOXIFEN RESISTANCE UP
NCI CD40 PATHWAY
SA MMP CYTOKINE CONNECTION
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
DORN ADENOVIRUS INFECTION 48HR UP
LINDSTEDT DENDRITIC CELL MATURATION A
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
KIM LRRC3B TARGETS
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
HORIUCHI WTAP TARGETS UP
NETPATH T CELL RECEPTOR PATHWAY DOWN
NCI IL23PATHWAY
ZHOU INFLAMMATORY RESPONSE LPS UP
NETPATH IL 4 PATHWAY DOWN
NOJIMA SFRP2 TARGETS DN
SANA TNF SIGNALING UP
NETPATH B CELL RECEPTOR PATHWAY
BROWNE HCMV INFECTION 2HR UP
RUTELLA RESPONSE TO CSF2RB AND IL4 DN
XU HGF TARGETS INDUCED BY AKT1 6HR
DORN ADENOVIRUS INFECTION 32HR UP
VERHAAK AML WITH NPM1 MUTATED UP
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN
MORI PRE BI LYMPHOCYTE DN
GEISS RESPONSE TO DSRNA UP
HINATA NFKB TARGETS KERATINOCYTE UP
MARKEY RB1 ACUTE LOF UP
JISON SICKLE CELL DISEASE UP
BASSO CD40 SIGNALING UP
HESS TARGETS OF HOXA9 AND MEIS1 DN
SOUCEK MYC TARGETS
HUMMEL BURKITTS LYMPHOMA DN
NUYTTEN EZH2 TARGETS UP
DUTTA APOPTOSIS VIA NFKB
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
DIRMEIER LMP1 RESPONSE EARLY
MAHADEVAN RESPONSE TO MP470 UP
HUANG DASATINIB RESISTANCE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
ehrlichia chaffeensis arkansamycobacterium tuberculosisaeromonas caviashigella dysenteriaeGeneSet Name
0.00029 0.00008 0.07215 0.08636NETPATH_IL_2_PATHWAY_UP
0.00000 0.00288 0.07318 0.00624NCI_IL6_7PATHWAY
0.00000 0.00171 0.00216 0.00147NETPATH_IL_3_PATHWAY_UP
0.00003 0.00000 0.10211 0.00000NETPATH_IL_6_PATHWAY_UP
0.00007 0.00000 0.07327 0.00014NETPATH_IL_5_PATHWAY_UP
0.00011 0.01106 0.03395 0.01729NETPATH_IL_4_PATHWAY_UP
0.00034 0.00856 0.16616 0.04120NETPATH_IL_7_PATHWAY_UP
0.00584 0.00010 0.11624 0.01233ST_TUMOR_NECROSIS_FACTOR_PATHWAY
0.00123 0.00000 0.11676 0.02436RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP
0.00021 0.00002 0.01924 0.00252GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.01097 0.00000 0.05120 0.00005DAUER_STAT3_TARGETS_UP
0.00001 0.00000 0.00001 0.00396LIANG_SILENCED_BY_METHYLATION_2
0.00097 0.08229 0.07320 0.05058NETPATH_IL_9_PATHWAY_UP
0.01198 0.00132 0.16652 0.00316MAHAJAN_RESPONSE_TO_IL1A_UP
0.04644 0.00017 0.10531 0.18395CHEN_LVAD_SUPPORT_OF_FAILING_HEART_DN
0.00000 0.00007 0.05933 0.00317KEGG_LEISHMANIA_INFECTION
0.00000 0.00000 0.00003 0.01598MCLACHLAN_DENTAL_CARIES_UP
0.00000 0.00287 0.04351 0.08170RUTELLA_RESPONSE_TO_HGF_DN
0.05834 0.00035 0.03175 0.00166VARELA_ZMPSTE24_TARGETS_UP
0.00000 0.00000 0.00015 0.02524BOYAULT_LIVER_CANCER_SUBCLASS_G5_DN
0.00000 0.13556 0.07889 0.08527TENEDINI_MEGAKARYOCYTE_MARKERS
0.00007 0.00000 0.00053 0.00053LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.07948 0.00573 0.00820 0.17588BECKER_TAMOXIFEN_RESISTANCE_UP
0.08348 0.01575 0.06428 0.00073NCI_CD40_PATHWAY
0.00037 0.00814 0.02492 0.10485SA_MMP_CYTOKINE_CONNECTION
0.00000 0.00000 0.00001 0.00236FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00000 0.00001 0.00003 0.02949MCLACHLAN_DENTAL_CARIES_DN
0.07893 0.06332 0.16772 0.05055DORN_ADENOVIRUS_INFECTION_48HR_UP
0.00000 0.00000 0.00124 0.00034LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00000 0.00000 0.00002 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00001 0.04466GAURNIER_PSMD4_TARGETS
0.00000 0.00000 0.00000 0.07873KIM_LRRC3B_TARGETS
0.00000 0.00000 0.00001 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00147 0.00000 0.12653 0.00236HORIUCHI_WTAP_TARGETS_UP
0.00211 0.00067 0.16575 0.18264NETPATH_T_CELL_RECEPTOR_PATHWAY_DOWN
0.00000 0.00126 0.00704 0.09953NCI_IL23PATHWAY
0.00269 0.00000 0.01590 0.03754ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00001 0.00000 0.01190 0.16501NETPATH_IL_4_PATHWAY_DOWN
0.00573 0.00051 0.00332 0.19222NOJIMA_SFRP2_TARGETS_DN
0.00000 0.00000 0.00000 0.00530SANA_TNF_SIGNALING_UP
0.00855 0.07142 0.13836 0.19501NETPATH_B_CELL_RECEPTOR_PATHWAY
0.15614 0.00000 0.05963 0.00008BROWNE_HCMV_INFECTION_2HR_UP
0.00000 0.00000 0.02718 0.01423RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN
0.03408 0.00001 0.15750 0.07814XU_HGF_TARGETS_INDUCED_BY_AKT1_6HR
0.12110 0.16621 0.15440 0.09973DORN_ADENOVIRUS_INFECTION_32HR_UP
0.00000 0.00000 0.08932 0.00095VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00000 0.00000 0.00001 0.18893FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN
0.00013 0.00014 0.00014 0.03794MORI_PRE_BI_LYMPHOCYTE_DN
0.00175 0.00000 0.00364 0.01687GEISS_RESPONSE_TO_DSRNA_UP
0.00055 0.00000 0.06206 0.00078HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00000 0.00000 0.00000 0.14227MARKEY_RB1_ACUTE_LOF_UP
0.00000 0.00000 0.00632 0.07115JISON_SICKLE_CELL_DISEASE_UP
0.00000 0.00000 0.00110 0.00004BASSO_CD40_SIGNALING_UP
0.00000 0.00000 0.01035 0.00054HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.00003 0.02521 0.00169 0.02047SOUCEK_MYC_TARGETS
0.00212 0.00035 0.11042 0.03331HUMMEL_BURKITTS_LYMPHOMA_DN
0.00475 0.00000 0.07444 0.08521NUYTTEN_EZH2_TARGETS_UP
0.00000 0.00002 0.05340 0.02611DUTTA_APOPTOSIS_VIA_NFKB
0.00001 0.00002 0.09323 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.00000 0.00564 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.00029 0.00004 0.00240 0.06328MAHADEVAN_RESPONSE_TO_MP470_UP
0.00143 0.00030 0.15881 0.16166HUANG_DASATINIB_RESISTANCE_UP
0.00000 0.00176 0.00008 0.17156REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES