BICLUSTER_ID : UPREG-356
PATHOGENS /3/ : lactobacillus acidophilus,helicobacter pylori,mycobacterium tuberculosis
TARGETS /8/ : VCAM1, STAT1, ICAM1, CASP1, CD86, CD40, TNFRSF1B, TNF
Gene SetLeading Edge Genes
NETPATH IL 2 PATHWAY UPIL4R, STAT1, ICAM1, CASP1, IRF1, TNFRSF1B, TNF
SA MMP CYTOKINE CONNECTIONSELL, TNFRSF1B, TNF
NCI IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELLVCAM1, SELL, CD40
NETPATH IL 4 PATHWAY DOWNTLR3, ICAM1, IRF1, CXCL2
NETPATH IL 7 PATHWAY UPFAS, CXCL1, CD86, CXCL2
NETPATH IL 3 PATHWAY UPCD86
NETPATH IL 5 PATHWAY UPTLR1, NFKBIE, ICAM1, RELB
NCI IL12 2PATHWAYSTAT1, NFKB2, RELB
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
RHEIN ALL GLUCOCORTICOID THERAPY UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
BIOCARTA PML PATHWAY
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
KEGG PRIMARY IMMUNODEFICIENCY
LINDGREN BLADDER CANCER CLUSTER 2B
KEGG GRAFT VERSUS HOST DISEASE
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
NCI PD 1 SIGNALING
RASHI RESPONSE TO IONIZING RADIATION 2
WALLACE PROSTATE CANCER RACE UP
MORI LARGE PRE BII LYMPHOCYTE DN
HORIUCHI WTAP TARGETS UP
WIELAND UP BY HBV INFECTION
BIOCARTA NKT PATHWAY
RUTELLA RESPONSE TO CSF2RB AND IL4 DN
BIOCARTA TH1TH2 PATHWAY
REACTOME SIGNALING IN IMMUNE SYSTEM
RUTELLA RESPONSE TO CSF2RB AND IL4 UP
DIRMEIER LMP1 RESPONSE LATE UP
MARKEY RB1 ACUTE LOF UP
BASSO CD40 SIGNALING UP
BIOCARTA BLYMPHOCYTE PATHWAY
BIOCARTA LYM PATHWAY
POOLA INVASIVE BREAST CANCER UP
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION
MAHADEVAN RESPONSE TO MP470 UP
SMID BREAST CANCER NORMAL LIKE UP
KEGG AUTOIMMUNE THYROID DISEASE
LIU VAV3 PROSTATE CARCINOGENESIS UP
FERRARI RESPONSE TO FENRETINIDE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN
KEGG VIRAL MYOCARDITIS
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP
LIAN LIPA TARGETS 6M
MCLACHLAN DENTAL CARIES UP
REACTOME COSTIMULATION BY THE CD28 FAMILY
BOYLAN MULTIPLE MYELOMA PCA1 UP
JAATINEN HEMATOPOIETIC STEM CELL DN
MCLACHLAN DENTAL CARIES DN
KEGG ALLOGRAFT REJECTION
SEKI INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 40 MCF10A
GAURNIER PSMD4 TARGETS
HELLER SILENCED BY METHYLATION UP
FARMER BREAST CANCER CLUSTER 1
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
SMID BREAST CANCER LUMINAL B DN
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP
NCI AMB2 NEUTROPHILS PATHWAY
SANA TNF SIGNALING UP
FOSTER INFLAMMATORY RESPONSE LPS UP
BROWNE HCMV INFECTION 2HR UP
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL
KEGG HEMATOPOIETIC CELL LINEAGE
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2
VERHAAK AML WITH NPM1 MUTATED UP
REACTOME G ALPHA I SIGNALLING EVENTS
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN
NCI IL12 STAT4PATHWAY
MORI IMMATURE B LYMPHOCYTE UP
NETPATH T CELL RECEPTOR PATHWAY UP
TIAN TNF SIGNALING VIA NFKB
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LU IL4 SIGNALING
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN
RUTELLA RESPONSE TO HGF UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
lactobacillus acidophilusmycobacterium tuberculosishelicobacter pyloriGeneSet Name
0.01173 0.00008 0.02714NETPATH_IL_2_PATHWAY_UP
0.11732 0.00814 0.01625SA_MMP_CYTOKINE_CONNECTION
0.00923 0.01857 0.00010NCI_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL
0.00012 0.00000 0.00844NETPATH_IL_4_PATHWAY_DOWN
0.06237 0.00856 0.06443NETPATH_IL_7_PATHWAY_UP
0.00372 0.00171 0.15967NETPATH_IL_3_PATHWAY_UP
0.01533 0.00000 0.03211NETPATH_IL_5_PATHWAY_UP
0.00000 0.00051 0.10271NCI_IL12_2PATHWAY
0.00000 0.00225 0.01320KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.09913 0.00003 0.17130RHEIN_ALL_GLUCOCORTICOID_THERAPY_UP
0.00598 0.00000 0.06395OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.01418 0.02320 0.06304BIOCARTA_PML_PATHWAY
0.00008 0.00002 0.01575GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.11821 0.03373 0.01196KEGG_PRIMARY_IMMUNODEFICIENCY
0.09463 0.00120 0.16246LINDGREN_BLADDER_CANCER_CLUSTER_2B
0.00180 0.02321 0.16793KEGG_GRAFT_VERSUS_HOST_DISEASE
0.00000 0.00000 0.01211ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.19783 0.10894 0.15650NCI_PD_1_SIGNALING
0.00034 0.00000 0.15090RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00000 0.00000 0.00000WALLACE_PROSTATE_CANCER_RACE_UP
0.05987 0.01956 0.00823MORI_LARGE_PRE_BII_LYMPHOCYTE_DN
0.00495 0.00000 0.13802HORIUCHI_WTAP_TARGETS_UP
0.00048 0.00000 0.00139WIELAND_UP_BY_HBV_INFECTION
0.00487 0.00137 0.09183BIOCARTA_NKT_PATHWAY
0.10725 0.00000 0.13865RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN
0.00113 0.13686 0.04641BIOCARTA_TH1TH2_PATHWAY
0.02614 0.00051 0.03692REACTOME_SIGNALING_IN_IMMUNE_SYSTEM
0.06788 0.00000 0.10621RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP
0.09243 0.00003 0.10819DIRMEIER_LMP1_RESPONSE_LATE_UP
0.00000 0.00000 0.03172MARKEY_RB1_ACUTE_LOF_UP
0.00000 0.00000 0.00046BASSO_CD40_SIGNALING_UP
0.01164 0.04300 0.00123BIOCARTA_BLYMPHOCYTE_PATHWAY
0.09025 0.18330 0.04199BIOCARTA_LYM_PATHWAY
0.11511 0.01142 0.00000POOLA_INVASIVE_BREAST_CANCER_UP
0.00200 0.00469 0.04674KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION
0.00272 0.00004 0.15994MAHADEVAN_RESPONSE_TO_MP470_UP
0.19514 0.15473 0.00012SMID_BREAST_CANCER_NORMAL_LIKE_UP
0.00927 0.00343 0.05509KEGG_AUTOIMMUNE_THYROID_DISEASE
0.02070 0.00067 0.01222LIU_VAV3_PROSTATE_CARCINOGENESIS_UP
0.15133 0.00018 0.03414FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00017 0.00176 0.00967REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.06805 0.00012 0.00145FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP
0.12763 0.00000 0.06401RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP
0.03726 0.00116 0.15939RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN
0.07903 0.19590 0.13897KEGG_VIRAL_MYOCARDITIS
0.01636 0.00000 0.13518NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP
0.01844 0.00002 0.13986LIAN_LIPA_TARGETS_6M
0.00667 0.00000 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.00914 0.01228 0.11722REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY
0.03024 0.07526 0.08203BOYLAN_MULTIPLE_MYELOMA_PCA1_UP
0.11272 0.00097 0.00000JAATINEN_HEMATOPOIETIC_STEM_CELL_DN
0.01242 0.00001 0.00000MCLACHLAN_DENTAL_CARIES_DN
0.00026 0.00549 0.02721KEGG_ALLOGRAFT_REJECTION
0.00000 0.00000 0.00826SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00031 0.00000 0.17677AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00000 0.00123GAURNIER_PSMD4_TARGETS
0.00489 0.00000 0.00668HELLER_SILENCED_BY_METHYLATION_UP
0.00000 0.00000 0.04805FARMER_BREAST_CANCER_CLUSTER_1
0.00000 0.00000 0.07962GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00000 0.12811ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.07352 0.07952 0.00142SMID_BREAST_CANCER_LUMINAL_B_DN
0.00084 0.00021 0.00022ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP
0.18674 0.09678 0.08456NCI_AMB2_NEUTROPHILS_PATHWAY
0.00000 0.00000 0.02871SANA_TNF_SIGNALING_UP
0.00000 0.00000 0.03242FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.06476 0.00000 0.06309BROWNE_HCMV_INFECTION_2HR_UP
0.02656 0.01587 0.00037REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL
0.02072 0.11260 0.06394KEGG_HEMATOPOIETIC_CELL_LINEAGE
0.01605 0.04041 0.11188SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2
0.03043 0.00000 0.19207VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.04481 0.10331 0.00115REACTOME_G_ALPHA_I_SIGNALLING_EVENTS
0.00001 0.00000 0.00409GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN
0.01239 0.13077 0.12199NCI_IL12_STAT4PATHWAY
0.01006 0.00002 0.02454MORI_IMMATURE_B_LYMPHOCYTE_UP
0.18163 0.12091 0.08386NETPATH_T_CELL_RECEPTOR_PATHWAY_UP
0.00000 0.00000 0.02721TIAN_TNF_SIGNALING_VIA_NFKB
0.00000 0.00000 0.15392KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00475 0.00000 0.05967OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00007 0.02153 0.14149LU_IL4_SIGNALING
0.01593 0.00002 0.00012BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP
0.14830 0.00812 0.02735DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN
0.03223 0.00000 0.02572RUTELLA_RESPONSE_TO_HGF_UP