BICLUSTER_ID : UPREG-404
PATHOGENS /2/ : bacillus anthracis,helicobacter pylori
TARGETS /13/ : NFKB1, LCN2, CCL20, XDH, JUN, CCL2, TAP1, IL6, PTGS2, GCH1, CCL5, ICAM1, PIM1
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPCSF3, CCL20, LCN2, JUN, CCL2, FOSL1, CCL7, RGS5, NFKBIA, CXCL2, CSF2, CCL4, PTX3, BIRC3, LIF, CXCL1, JMJD3, TNFAIP6, IL6, PTGS2, PBEF1, ICAM1
NETPATH IL 4 PATHWAY DOWNCCL20, GADD45B, CCL2, GBP2, NFKBIA, IL6, PTGS2, ICAM1, IRF1, CXCL2
NETPATH KIT RECEPTOR PATHWAY UPJUNB, CCL2, TAP1, VEGF, IL6, SOCS1, CCL5, PIM1, CSF2, IER3
GERY CEBP TARGETSGADD45B, LCN2, TRIB3, CXCL1, XDH, EREG, JUNB, GADD45G, TNFAIP6, GCH1, IFRD1, PIM1, RASL11B, DUSP1, PTX3
NETPATH IL 3 PATHWAY UPCCL7, SOCS1, CCL2, PIM1, CCL4
NCI NFKAPPABALTERNATIVEPATHWAYNFKB1, NFKB2, RELB
CORUM IKBA-NFKAPPABP65-NFKAPPABP50 COMPLEXNFKB1, NFKBIA
CORUM NFKB1-NFKB2-RELA-RELB COMPLEXNFKB1, NFKB2, RELB
NCI NF KB IS ACTIVATED AND SIGNALS SURVIVALNFKB1, NFKBIA
NCI IL23PATHWAYNFKBIA, IL6, CXCL1, CXCL9
CORUM NFKB1-NFKB2-REL-RELA-RELB COMPLEXNFKB1, REL, NFKB2, RELB
CORUM IKAPPABALPHA-NFKAPPABP50-NFKAPPABP65 COMPLEXNFKB1, NFKBIA
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
NOJIMA SFRP2 TARGETS UP
CHEN HOXA5 TARGETS 6HR UP
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
LEONARD HYPOXIA
BIOCARTA STEM PATHWAY
MAHAJAN RESPONSE TO IL1A UP
BIOCARTA EPONFKB PATHWAY
KEGG GRAFT VERSUS HOST DISEASE
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS
AUJLA IL22 AND IL17A SIGNALING
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
LINDSTEDT DENDRITIC CELL MATURATION B
SA MMP CYTOKINE CONNECTION
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
KIM LRRC3B TARGETS
AMIT EGF RESPONSE 40 HELA
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5
MAHADEVAN RESPONSE TO MP470 DN
BROWNE INTERFERON RESPONSIVE GENES
HARRIS HYPOXIA
BIOCARTA LAIR PATHWAY
HINATA NFKB TARGETS KERATINOCYTE UP
BIOCARTA CYTOKINE PATHWAY
REACTOME CALCITONIN LIKE LIGAND RECEPTORS
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
GILMORE CORE NFKB PATHWAY
CORUM IKBALPHA-RELA-CREL COMPLEXNFKBIA, REL
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
MAHADEVAN RESPONSE TO MP470 UP
SEMENZA HIF1 TARGETS
FERRARI RESPONSE TO FENRETINIDE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
BIOCARTA CD40 PATHWAY
BILD HRAS ONCOGENIC SIGNATURE
SANA RESPONSE TO IFNG UP
ONDER CDH1 TARGETS 3 DN
DAUER STAT3 TARGETS UP
BIOCARTA RANKL PATHWAY
MCLACHLAN DENTAL CARIES UP
CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX CHUK KPNA3 NFKB2 NFKBIB REL IKBKG NFKB1 NFKBIE RELB NFKBIA RELA TNIP2
DAZARD UV RESPONSE CLUSTER G2
MCLACHLAN DENTAL CARIES DN
AMIT SERUM RESPONSE 40 MCF10A
RAY ALZHEIMERS DISEASE
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHU CMV 8 HR UP
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP
BIERIE INFLAMMATORY RESPONSE TGFB1
ZHOU INFLAMMATORY RESPONSE LPS UP
GESERICK TERT TARGETS DN
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP
WONG ENDMETRIUM CANCER UP
FOSTER INFLAMMATORY RESPONSE LPS UP
BROWNE HCMV INFECTION 2HR UP
CORUM REL-MAP3K8-RELA-TNIP2-PAPOLA COMPLEXREL, MAP3K8
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
VERHAAK AML WITH NPM1 MUTATED UP
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
KOBAYASHI EGFR SIGNALING 6HR DN
BIOCARTA GRANULOCYTES PATHWAY
BIOCARTA TNFR2 PATHWAY
AMIT EGF RESPONSE 120 MCF10A
TIAN TNF SIGNALING VIA NFKB
FARMER BREAST CANCER CLUSTER 3
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
FARMER BREAST CANCER CLUSTER 4
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
WEBER METHYLATED ICP IN SPERM DN
PRAMOONJAGO SOX4 TARGETS UP
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
bacillus anthracishelicobacter pylori kx1 npgecGeneSet Name
0.00738 0.00201NETPATH_IL_1_PATHWAY_UP
0.12825 0.00644NETPATH_IL_4_PATHWAY_DOWN
0.01116 0.09166NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.01488 0.04422GERY_CEBP_TARGETS
0.19023 0.05322NETPATH_IL_3_PATHWAY_UP
0.12358 0.00027NCI_NFKAPPABALTERNATIVEPATHWAY
0.12539 0.15694CORUM_IKBA-NFKAPPABP65-NFKAPPABP50_COMPLEX
0.05401 0.08355CORUM_NFKB1-NFKB2-RELA-RELB_COMPLEX
0.01077 0.19145NCI_NF_KB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL
0.00010 0.14576NCI_IL23PATHWAY
0.02270 0.03228CORUM_NFKB1-NFKB2-REL-RELA-RELB_COMPLEX
0.13790 0.18970CORUM_IKAPPABALPHA-NFKAPPABP50-NFKAPPABP65_COMPLEX
0.00020 0.06985KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00004 0.01127NOJIMA_SFRP2_TARGETS_UP
0.04547 0.08749CHEN_HOXA5_TARGETS_6HR_UP
0.06111 0.00255MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.01784 0.09695OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.15911 0.18497GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.03520 0.00008LEONARD_HYPOXIA
0.18850 0.01484BIOCARTA_STEM_PATHWAY
0.01475 0.00083MAHAJAN_RESPONSE_TO_IL1A_UP
0.07439 0.04104BIOCARTA_EPONFKB_PATHWAY
0.03120 0.07771KEGG_GRAFT_VERSUS_HOST_DISEASE
0.06042 0.01155REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
0.19473 0.04599AUJLA_IL22_AND_IL17A_SIGNALING
0.00986 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.14368 0.00213REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.00000 0.00011LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.15130 0.13965SA_MMP_CYTOKINE_CONNECTION
0.00554 0.10813RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00000 0.00003LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.15773 0.00152KIM_LRRC3B_TARGETS
0.00021 0.12195AMIT_EGF_RESPONSE_40_HELA
0.02634 0.02657YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5
0.19442 0.09518MAHADEVAN_RESPONSE_TO_MP470_DN
0.15574 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.07884 0.08612HARRIS_HYPOXIA
0.00839 0.11387BIOCARTA_LAIR_PATHWAY
0.00000 0.00256HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00101 0.15912BIOCARTA_CYTOKINE_PATHWAY
0.03129 0.07421REACTOME_CALCITONIN_LIKE_LIGAND_RECEPTORS
0.00215 0.06948KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.12757BASSO_CD40_SIGNALING_UP
0.00345 0.00009SOUCEK_MYC_TARGETS
0.00319 0.00208GILMORE_CORE_NFKB_PATHWAY
0.14500 0.13883CORUM_IKBALPHA-RELA-CREL_COMPLEX
0.01600 0.05736DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.06932DIRMEIER_LMP1_RESPONSE_EARLY
0.00593 0.00000MAHADEVAN_RESPONSE_TO_MP470_UP
0.13108 0.01227SEMENZA_HIF1_TARGETS
0.01068 0.11271FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00253 0.00000REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.03511 0.13504BIOCARTA_CD40_PATHWAY
0.13675 0.16783BILD_HRAS_ONCOGENIC_SIGNATURE
0.09919 0.00000SANA_RESPONSE_TO_IFNG_UP
0.00403 0.06938ONDER_CDH1_TARGETS_3_DN
0.00062 0.01934DAUER_STAT3_TARGETS_UP
0.02228 0.04517BIOCARTA_RANKL_PATHWAY
0.11704 0.02102MCLACHLAN_DENTAL_CARIES_UP
0.01201 0.10289CORUM_TNF-ALPHA/NF-KAPPA_B_SIGNALING_COMPLEX_CHUK_KPNA3_NFKB2_NFKBIB_REL_IKBKG__NFKB1_NFKBIE_RELB__NFKBIA_RELA_TNIP2
0.15429 0.15355DAZARD_UV_RESPONSE_CLUSTER_G2
0.12968 0.06509MCLACHLAN_DENTAL_CARIES_DN
0.00325 0.13910AMIT_SERUM_RESPONSE_40_MCF10A
0.19829 0.09675RAY_ALZHEIMERS_DISEASE
0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000GAURNIER_PSMD4_TARGETS
0.00009 0.00796GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00002ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.07377 0.00000ZHU_CMV_8_HR_UP
0.11881 0.15656ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP
0.09476 0.00805BIERIE_INFLAMMATORY_RESPONSE_TGFB1
0.00000 0.00001ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00454 0.01048GESERICK_TERT_TARGETS_DN
0.00049 0.04107BIOCARTA_INFLAM_PATHWAY
0.00096 0.00000SANA_TNF_SIGNALING_UP
0.16722 0.02651TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP
0.04519 0.09571WONG_ENDMETRIUM_CANCER_UP
0.19461 0.03879FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.00022 0.02678BROWNE_HCMV_INFECTION_2HR_UP
0.18566 0.05756CORUM_REL-MAP3K8-RELA-TNIP2-PAPOLA_COMPLEX
0.00029 0.06147HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00551 0.06454VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.03512 0.00002GEISS_RESPONSE_TO_DSRNA_UP
0.02609 0.00515KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00003 0.00603UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.00025 0.10830KOBAYASHI_EGFR_SIGNALING_6HR_DN
0.03044 0.00519BIOCARTA_GRANULOCYTES_PATHWAY
0.00304 0.02476BIOCARTA_TNFR2_PATHWAY
0.14343 0.19126AMIT_EGF_RESPONSE_120_MCF10A
0.00000 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.15860 0.02765FARMER_BREAST_CANCER_CLUSTER_3
0.14821 0.00201ZHU_CMV_ALL_UP
0.15813 0.14588KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00039GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.12697 0.04086FARMER_BREAST_CANCER_CLUSTER_4
0.01781 0.10013OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00308 0.18870LEE_LIVER_CANCER_HEPATOBLAST
0.00000 0.02425ZUCCHI_METASTASIS_DN
0.00009 0.01564NAGASHIMA_EGF_SIGNALING_UP
0.15750 0.12214WEBER_METHYLATED_ICP_IN_SPERM_DN
0.08362 0.00004PRAMOONJAGO_SOX4_TARGETS_UP
0.00000 0.05134HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00559 0.04711AMIT_EGF_RESPONSE_60_MCF10A