BICLUSTER_ID : UPREG-442
PATHOGENS /3/ : mycobacterium tuberculosis,streptococcus pyogenes,helicobacter pylori
TARGETS /7/ : IL6, CCL20, HMOX1, GCH1, ICAM1, CCL2, PIM1
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPIL6, BIRC3, CCL20, CXCL1, ICAM1, CCL2, CXCL2
GERY CEBP TARGETSGADD45B, HMOX1, GCH1, JUNB, DDIT3, PIM1
NETPATH IL 6 PATHWAY UPGADD45B, CEBPB, JUNB, PIM1, BCL3, MAP3K8
NOJIMA SFRP2 TARGETS UP
CHEN HOXA5 TARGETS 6HR UP
NCI AUTODEGRADATION OF CDH1 BY CDH1 APC C
CORUM NFKB1-NFKB2-RELA-RELB COMPLEX
BIOCARTA STEM PATHWAY
DAUER STAT3 TARGETS UP
NETPATH IL 9 PATHWAY UP
TURJANSKI MAPK7 TARGETS
MAHAJAN RESPONSE TO IL1A UP
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G
NCI CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
KEGG GRAFT VERSUS HOST DISEASE
PARK TRETINOIN RESPONSE
LINDSTEDT DENDRITIC CELL MATURATION B
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN
NCI HOST INTERACTIONS OF HIV FACTORSPSME2, PSMB8, PSMB10, PSME1, PSMB9
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
NCI APC C CDC20 MEDIATED DEGRADATION OF SECURIN
REACTOME P53 INDEPENDENT DNA DAMAGE RESPONSE
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
PARK TRETINOIN RESPONSE AND PML RARA FUSION
XU HGF TARGETS REPRESSED BY AKT1 UP
COATES MACROPHAGE M1 VS M2 DN
GESERICK TERT TARGETS DN
NCI UBIQUITIN DEPENDENT DEGRADATION OF CYCLIN D1PSME2, PSMB8, PSMB9, PSME1
NCI REGULATION OF ORNITHINE DECARBOXYLASE ODC
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21
REACTOME SIGNALING BY WNT
REACTOME STABILIZATION OF P53
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1
HARRIS HYPOXIA
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC
HINATA NFKB TARGETS KERATINOCYTE UP
AMIT EGF RESPONSE 20 HELA
BIOCARTA TCAPOPTOSIS PATHWAY
SOUCEK MYC TARGETS
TIAN TNF SIGNALING VIA NFKB
GILMORE CORE NFKB PATHWAY
DUTTA APOPTOSIS VIA NFKB
NCI SCF BETA TRCP MEDIATED DEGRADATION OF EMI1PSME2, PSMB8, PSMB10, PSME1, PSMB9
NCI PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS
KEGG PROTEASOME
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
CORUM NFKB1-NFKB2-REL-RELA-RELB COMPLEX
ZUCCHI METASTASIS DN
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATIONPSME2, PSMB8, PSMB10, PSME1, PSMB9
DIRMEIER LMP1 RESPONSE EARLY
NCI UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25APSME2, PSMB8, PSMB10, PSME1, PSMB9
NCI APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1
MAHADEVAN RESPONSE TO MP470 UP
PRAMOONJAGO SOX4 TARGETS UP
HINATA NFKB TARGETS FIBROBLAST UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
helicobacter pylori kx2 npgecstreptococcus pyogenesmycobacterium tuberculosisGeneSet Name
0.08273 0.03192 0.00602NETPATH_IL_1_PATHWAY_UP
0.14043 0.01652 0.00000GERY_CEBP_TARGETS
0.13630 0.00001 0.00000NETPATH_IL_6_PATHWAY_UP
0.03559 0.08281 0.00000NOJIMA_SFRP2_TARGETS_UP
0.18281 0.12534 0.00079CHEN_HOXA5_TARGETS_6HR_UP
0.00000 0.07133 0.08317NCI_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C
0.04955 0.15921 0.04157CORUM_NFKB1-NFKB2-RELA-RELB_COMPLEX
0.08374 0.03626 0.14979BIOCARTA_STEM_PATHWAY
0.04938 0.00038 0.00000DAUER_STAT3_TARGETS_UP
0.03276 0.00011 0.08229NETPATH_IL_9_PATHWAY_UP
0.13661 0.11230 0.18996TURJANSKI_MAPK7_TARGETS
0.05579 0.17839 0.00132MAHAJAN_RESPONSE_TO_IL1A_UP
0.00000 0.01918 0.00468REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
0.00000 0.01320 0.03019NCI_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6
0.11321 0.01028 0.02002NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.09151 0.01019 0.02321KEGG_GRAFT_VERSUS_HOST_DISEASE
0.03059 0.14849 0.00298PARK_TRETINOIN_RESPONSE
0.00320 0.02304 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00000 0.00128 0.00008PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN
0.00000 0.00865 0.00787NCI_HOST_INTERACTIONS_OF_HIV_FACTORS
0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00011 0.00000 0.00000GAURNIER_PSMD4_TARGETS
0.00000 0.11025 0.17875NCI_APC_C_CDC20_MEDIATED_DEGRADATION_OF_SECURIN
0.00000 0.01656 0.01493REACTOME_P53_INDEPENDENT_DNA_DAMAGE_RESPONSE
0.08415 0.05533 0.00000GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.01844 0.00019 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.13068 0.00624 0.00026PARK_TRETINOIN_RESPONSE_AND_PML_RARA_FUSION
0.15627 0.14382 0.06625XU_HGF_TARGETS_REPRESSED_BY_AKT1_UP
0.14943 0.01553 0.02011COATES_MACROPHAGE_M1_VS_M2_DN
0.01236 0.01538 0.00002GESERICK_TERT_TARGETS_DN
0.00000 0.02264 0.00551NCI_UBIQUITIN_DEPENDENT_DEGRADATION_OF_CYCLIN_D1
0.00000 0.01121 0.02665NCI_REGULATION_OF_ORNITHINE_DECARBOXYLASE__ODC_
0.00000 0.03648 0.02161REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE
0.00000 0.07566 0.07509REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21
0.00000 0.06938 0.00505REACTOME_SIGNALING_BY_WNT
0.00000 0.02658 0.00975REACTOME_STABILIZATION_OF_P53
0.00000 0.02309 0.03860REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
0.01945 0.15102 0.00067HARRIS_HYPOXIA
0.00000 0.09468 0.07867REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC
0.16190 0.05930 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.11482 0.10732 0.00486AMIT_EGF_RESPONSE_20_HELA
0.07643 0.02578 0.16209BIOCARTA_TCAPOPTOSIS_PATHWAY
0.01521 0.00021 0.02521SOUCEK_MYC_TARGETS
0.00000 0.00455 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.01817 0.06138 0.00092GILMORE_CORE_NFKB_PATHWAY
0.03297 0.02575 0.00002DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.01835 0.00570NCI_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
0.09853 0.00955 0.15010NCI_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS
0.00000 0.01420 0.00367KEGG_PROTEASOME
0.01942 0.05507 0.00002GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.06149 0.17781 0.05523CORUM_NFKB1-NFKB2-REL-RELA-RELB_COMPLEX
0.03486 0.01684 0.00039ZUCCHI_METASTASIS_DN
0.00000 0.00873 0.00636NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION
0.14826 0.00616 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.00000 0.01493 0.01224NCI_UBIQUITIN_MEDIATED_DEGRADATION_OF_PHOSPHORYLATED_CDC25A
0.00000 0.06946 0.08118NCI_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1
0.00810 0.01593 0.00004MAHADEVAN_RESPONSE_TO_MP470_UP
0.00069 0.19931 0.00000PRAMOONJAGO_SOX4_TARGETS_UP
0.10685 0.14412 0.00000HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00042 0.00007 0.00176REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES