BICLUSTER_ID : UPREG-468
PATHOGENS /3/ : helicobacter pylori,brucella melitensis,ehrlichia chaffeensis
TARGETS /4/ : IL6, PTGS2, ICAM1, CCL2
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPBIRC3, CCL2, NFKBIA, CCL7, IL6, PTGS2, MT2A, ICAM1, CXCL2, MYC
NETPATH IL 9 PATHWAY UPCCL7, CCL2, JUNB, MYC, GZMA
NCI AUTODEGRADATION OF CDH1 BY CDH1 APC C
ONDER CDH1 TARGETS 3 DN
REACTOME CDC20 PHOSPHO APC MEDIATED DEGRADATION OF CYCLIN A
DAUER STAT3 TARGETS UP
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G
NCI CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6
NETPATH IL 6 PATHWAY UPGADD45B, JUNB
KEGG GRAFT VERSUS HOST DISEASE
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS
AUJLA IL22 AND IL17A SIGNALING
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
CHEN HOXA5 TARGETS 9HR UP
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN
LINDSTEDT DENDRITIC CELL MATURATION B
NCI HOST INTERACTIONS OF HIV FACTORS
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
NCI APC C CDC20 MEDIATED DEGRADATION OF SECURIN
REACTOME P53 INDEPENDENT DNA DAMAGE RESPONSE
NCI CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
BIERIE INFLAMMATORY RESPONSE TGFB1
GESERICK TERT TARGETS DN
NCI UBIQUITIN DEPENDENT DEGRADATION OF CYCLIN D1
NCI CDC20 PHOSPHO APC C MEDIATED DEGRADATION OF CYCLIN A
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE
NCI REGULATION OF ORNITHINE DECARBOXYLASE ODC PSMA1, PSMA7, PSME1
REACTOME STABILIZATION OF P53
REACTOME SCF SKP2 MEDIATED DEGRADATION OF P27 P21
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1
HARRIS HYPOXIA
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC
HINATA NFKB TARGETS KERATINOCYTE UP
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
BIOCARTA GRANULOCYTES PATHWAY
ST TUMOR NECROSIS FACTOR PATHWAYNFKBIA, BIRC3, NFKB2
NAGASHIMA NRG1 SIGNALING UP
SOUCEK MYC TARGETS
TIAN TNF SIGNALING VIA NFKB
NCI SCF BETA TRCP MEDIATED DEGRADATION OF EMI1
DUTTA APOPTOSIS VIA NFKB
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX
KEGG PROTEASOME
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATION
NAGASHIMA EGF SIGNALING UP
DIRMEIER LMP1 RESPONSE EARLY
NCI UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A
NCI APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1
MAHADEVAN RESPONSE TO MP470 UP
AMIT EGF RESPONSE 60 MCF10A
HINATA NFKB TARGETS FIBROBLAST UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
helicobacter pylori kx2 npgecehrlichia chaffeensis arkansabrucella melitensisGeneSet Name
0.08273 0.00744 0.00061NETPATH_IL_1_PATHWAY_UP
0.03276 0.00097 0.00000NETPATH_IL_9_PATHWAY_UP
0.00000 0.09820 0.01494NCI_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C
0.07857 0.02809 0.00670ONDER_CDH1_TARGETS_3_DN
0.00000 0.12269 0.01290REACTOME_CDC20_PHOSPHO_APC_MEDIATED_DEGRADATION_OF_CYCLIN_A
0.04938 0.01097 0.00563DAUER_STAT3_TARGETS_UP
0.00000 0.06904 0.00544REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
0.00000 0.05794 0.00670NCI_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6
0.13630 0.00003 0.00163NETPATH_IL_6_PATHWAY_UP
0.09151 0.00000 0.00487KEGG_GRAFT_VERSUS_HOST_DISEASE
0.03582 0.00034 0.07382REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS
0.08713 0.00697 0.05167AUJLA_IL22_AND_IL17A_SIGNALING
0.01462 0.00094 0.03016REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.09671 0.01709 0.08869CHEN_HOXA5_TARGETS_9HR_UP
0.00000 0.02780 0.00728PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN
0.00320 0.00007 0.01411LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00000 0.03268 0.00509NCI_HOST_INTERACTIONS_OF_HIV_FACTORS
0.00000 0.00000 0.00010SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00011 0.00000 0.00642GAURNIER_PSMD4_TARGETS
0.00000 0.09958 0.01361NCI_APC_C_CDC20_MEDIATED_DEGRADATION_OF_SECURIN
0.00000 0.03913 0.00576REACTOME_P53_INDEPENDENT_DNA_DAMAGE_RESPONSE
0.00000 0.06653 0.02209NCI_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX
0.08415 0.00007 0.02218GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.01844 0.00000 0.00017ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.03130 0.03251 0.07093BIERIE_INFLAMMATORY_RESPONSE_TGFB1
0.01236 0.00047 0.04550GESERICK_TERT_TARGETS_DN
0.00000 0.04561 0.00535NCI_UBIQUITIN_DEPENDENT_DEGRADATION_OF_CYCLIN_D1
0.00000 0.10676 0.01697NCI_CDC20_PHOSPHO_APC_C_MEDIATED_DEGRADATION_OF_CYCLIN_A
0.00000 0.02844 0.02111REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE
0.00000 0.01628 0.00707NCI_REGULATION_OF_ORNITHINE_DECARBOXYLASE__ODC_
0.00000 0.05325 0.01983REACTOME_STABILIZATION_OF_P53
0.00000 0.09686 0.00499REACTOME_SCF_SKP2_MEDIATED_DEGRADATION_OF_P27_P21
0.00000 0.06648 0.00836REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
0.01945 0.00160 0.04905HARRIS_HYPOXIA
0.00000 0.08549 0.01139REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC
0.16190 0.00055 0.05127HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.03267 0.02814 0.05866UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.01885 0.00024 0.00520BIOCARTA_GRANULOCYTES_PATHWAY
0.02351 0.00584 0.00659ST_TUMOR_NECROSIS_FACTOR_PATHWAY
0.08878 0.00648 0.13564NAGASHIMA_NRG1_SIGNALING_UP
0.01521 0.00003 0.00824SOUCEK_MYC_TARGETS
0.00000 0.00003 0.00659TIAN_TNF_SIGNALING_VIA_NFKB
0.00000 0.07201 0.00899NCI_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
0.03297 0.00000 0.00246DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.07731 0.01957REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX
0.00000 0.03642 0.00674KEGG_PROTEASOME
0.01942 0.00001 0.00050GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.02962 0.00456NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION
0.01745 0.00040 0.04193NAGASHIMA_EGF_SIGNALING_UP
0.14826 0.00000 0.00015DIRMEIER_LMP1_RESPONSE_EARLY
0.00000 0.04449 0.00640NCI_UBIQUITIN_MEDIATED_DEGRADATION_OF_PHOSPHORYLATED_CDC25A
0.00000 0.09494 0.01608NCI_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1
0.00810 0.00029 0.15514MAHADEVAN_RESPONSE_TO_MP470_UP
0.03534 0.02646 0.02006AMIT_EGF_RESPONSE_60_MCF10A
0.10685 0.00358 0.15037HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00042 0.00000 0.02236REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES