BICLUSTER_ID : UPREG-470
PATHOGENS /2/ : aeromonas caviae,brucella ovis
TARGETS /27/ : SDHB, PLA2G2A, NDUFA5, ATP5D, NDUFB8, CD40, TNFRSF1B, CD80, NDUFB5, CD40LG, PIM1, IL2RA, MPO, NDUFA8, GZMB, NDUFB7, STAT1, CCL8, LTB, NDUFB6, IL2RG, NDUFA4, NDUFAB1, IL1B, NDUFB2, TNF, NDUFC1
Gene SetLeading Edge Genes
MOOTHA VOXPHOSATP5I, SDHB, ATP5D, NDUFA5, NDUFB8, UQCRH, COX7A1, NDUFB5, CYC1, NDUFA8, NDUFB7, ATP5O, ATP5G1, NDUFB6, NDUFA4, NDUFAB1, COX6C, NDUFB2, UQCRC2, NDUFC1
NETPATH IL 2 PATHWAY UPSTAT5A, NMI, CREM, IFIT1, NFIL3, NRL, LCP2, IFITM3, IL1B, CCL3, IRF1, MYC, UPP1, AHR, GBP1, ISGF3G, TNFRSF1B, TRAFD1, SOCS3, CD40LG, SOCS1, IL2RA, PIM1, GZMB, CCL4, STAT1, GPLD1, TRIM21, IL2RG, FAS, DAXX, CTSC, GZMA
NCI IL12 2PATHWAYSTAT1, CD247, STAT5A, IL2RG, IL1B, CCL3, SOCS1, IL2RA, GZMA, CCL4, GZMB
NETPATH IL 7 PATHWAY UPCCL8, STAT5A, CD80, FAS, CCL3, CD40LG, IL2RA, MYC, CCL4
NCI IL23PATHWAYSOCS3, NFKBIA, STAT1, IL1B, MPO, TNF
SA MMP CYTOKINE CONNECTIONIL1B, TNFRSF1B, TNF
NETPATH IL 4 PATHWAY DOWNPDGFB, STAT1, LTB, GAS1, NFKBIA, CHI3L1, GEM, IRF1, TNF, GZMA
NETPATH IL 6 PATHWAY UPSTAT1, PLA2G2A, CISH, NMI, SOCS3, SOCS1, PIM1, IRF1
NETPATH IL 9 PATHWAY UPSOCS3, CCL3, PIM1, CISH, MYC, GZMB, GZMA
NETPATH IL 3 PATHWAY UPCISH, SOCS3, NFIL3, CCL3, IL1B, SOCS1, PIM1, MYC, CCL4
NETPATH IL 5 PATHWAY UPNFIL3, CYP1A2, BIRC3, CCL3, CTSC, IL2RA, PIM1, UPP1
NCI CD40 PATHWAYTRAF1, NFKBIA, BIRC3, CD40LG, TRAF3, CD40, STAT5A, MYC
ST TUMOR NECROSIS FACTOR PATHWAYNFKBIA, BIRC3, TNFRSF1B
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
MAHAJAN RESPONSE TO IL1A UP
ZHANG INTERFERON RESPONSE
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER
AUJLA IL22 AND IL17A SIGNALING
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
LINDSTEDT DENDRITIC CELL MATURATION B
SCHUHMACHER MYC TARGETS DN
SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN
LINDSTEDT DENDRITIC CELL MATURATION A
RADAEVA RESPONSE TO IFNA1 UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP
BOWIE RESPONSE TO EXTRACELLULAR MATRIX
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN UP
UROSEVIC RESPONSE TO IMIQUIMOD
BROWNE INTERFERON RESPONSIVE GENES
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP
HINATA NFKB TARGETS KERATINOCYTE UP
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP
BASSO CD40 SIGNALING UP
KORKOLA YOLK SAC TUMOR
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
BOYLAN MULTIPLE MYELOMA C D DN
DIRMEIER LMP1 RESPONSE EARLY
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
KEGG LEISHMANIA INFECTION
MCLACHLAN DENTAL CARIES UP
JAATINEN HEMATOPOIETIC STEM CELL DN
ISHIKAWA STING SIGNALING
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
KEGG ALLOGRAFT REJECTION
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
CORUM 39S RIBOSOMAL SUBUNIT MITOCHONDRIALMRPL41, MRPL54, MRPL17, MRPL35, MRPL3, MRPL52, MRPL40, MRPL15, MRPL20, MRPL50, MRPL51, MRPL45, MRPL16, MRPL53, MRPL21, MRPL39, MRPL14
HELLER SILENCED BY METHYLATION UP
GRANDVAUX IFN RESPONSE NOT VIA IRF3
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
BOWIE RESPONSE TO TAMOXIFEN
SMID BREAST CANCER LUMINAL B DN
ZHOU INFLAMMATORY RESPONSE LPS UP
SANA TNF SIGNALING UP
BOQUEST STEM CELL CULTURED VS FRESH DN
MOSERLE IFNA RESPONSE
FOSTER INFLAMMATORY RESPONSE LPS UP
XU HGF TARGETS INDUCED BY AKT1 6HR
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL
VERHAAK AML WITH NPM1 MUTATED UP
LIAN LIPA TARGETS 3M
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1
BIOCARTA GRANULOCYTES PATHWAY
CORUM 55S RIBOSOME MITOCHONDRIALMRPS25, MRPL41, MRPS7, MRPL54, MRPS12, MRPL17, MRPS11, MRPL35, MRPS33, MRPL3, MRPL40, MRPL52, MRPL15, MRPS28, MRPS5, MRPL20, MRPL50, MRPS26, MRPS18B, MRPL51, MRPL45, MRPS36, MRPS10, MRPL16, MRPS31, MRPL53, MRPS14, MRPL21, MRPL39, MRPL14
CHIANG LIVER CANCER SUBCLASS INTERFERON UP
WONG EMBRYONIC STEM CELL CORE
ZHU CMV ALL UP
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
brucella ovisaeromonas caviaGeneSet Name
0.11154 0.00000MOOTHA_VOXPHOS
0.18663 0.07215NETPATH_IL_2_PATHWAY_UP
0.14294 0.00545NCI_IL12_2PATHWAY
0.01316 0.16616NETPATH_IL_7_PATHWAY_UP
0.05836 0.00704NCI_IL23PATHWAY
0.18285 0.02492SA_MMP_CYTOKINE_CONNECTION
0.00062 0.01190NETPATH_IL_4_PATHWAY_DOWN
0.01065 0.10211NETPATH_IL_6_PATHWAY_UP
0.00706 0.07320NETPATH_IL_9_PATHWAY_UP
0.00156 0.00216NETPATH_IL_3_PATHWAY_UP
0.03173 0.07327NETPATH_IL_5_PATHWAY_UP
0.14332 0.06428NCI_CD40_PATHWAY
0.06146 0.11624ST_TUMOR_NECROSIS_FACTOR_PATHWAY
0.03342 0.01697KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.07308 0.01924GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.08148 0.16652MAHAJAN_RESPONSE_TO_IL1A_UP
0.14676 0.00003ZHANG_INTERFERON_RESPONSE
0.11543 0.05653SATO_SILENCED_EPIGENETICALLY_IN_PANCREATIC_CANCER
0.13604 0.01459AUJLA_IL22_AND_IL17A_SIGNALING
0.03248 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.12412 0.13954REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.02851 0.00053LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.03250 0.11083SCHUHMACHER_MYC_TARGETS_DN
0.16988 0.05537SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_DN
0.00044 0.00124LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.11979 0.00000RADAEVA_RESPONSE_TO_IFNA1_UP
0.12412 0.00001TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP
0.19318 0.00058BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX
0.12619 0.02237ZHANG_ANTIVIRAL_RESPONSE_TO_RIBAVIRIN_UP
0.06159 0.00001UROSEVIC_RESPONSE_TO_IMIQUIMOD
0.12548 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.04753 0.00000TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP
0.18029 0.16527TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP
0.03817 0.06206HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.05086 0.00000SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP
0.08843 0.00110BASSO_CD40_SIGNALING_UP
0.17009 0.05970KORKOLA_YOLK_SAC_TUMOR
0.00716 0.00169SOUCEK_MYC_TARGETS
0.01264 0.05340DUTTA_APOPTOSIS_VIA_NFKB
0.18270 0.00178BOYLAN_MULTIPLE_MYELOMA_C_D_DN
0.01330 0.00564DIRMEIER_LMP1_RESPONSE_EARLY
0.05049 0.00008REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.03492 0.00003SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP
0.05898 0.00041BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS
0.12476 0.10841KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.10980 0.05120DAUER_STAT3_TARGETS_UP
0.03860 0.00001LIANG_SILENCED_BY_METHYLATION_2
0.13650 0.05933KEGG_LEISHMANIA_INFECTION
0.03202 0.00003MCLACHLAN_DENTAL_CARIES_UP
0.16593 0.01353JAATINEN_HEMATOPOIETIC_STEM_CELL_DN
0.12495 0.00242ISHIKAWA_STING_SIGNALING
0.04589 0.03029PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN
0.01159 0.00001FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.04417 0.00003MCLACHLAN_DENTAL_CARIES_DN
0.13146 0.01652KEGG_ALLOGRAFT_REJECTION
0.00076 0.00002SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00581 0.00001GAURNIER_PSMD4_TARGETS
0.14318 0.00000CORUM_39S_RIBOSOMAL_SUBUNIT_MITOCHONDRIAL
0.11472 0.00206HELLER_SILENCED_BY_METHYLATION_UP
0.10265 0.00003GRANDVAUX_IFN_RESPONSE_NOT_VIA_IRF3
0.00055 0.00001ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.09220 0.00004BOWIE_RESPONSE_TO_TAMOXIFEN
0.19116 0.08643SMID_BREAST_CANCER_LUMINAL_B_DN
0.04278 0.01590ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.01931 0.00000SANA_TNF_SIGNALING_UP
0.00601 0.16593BOQUEST_STEM_CELL_CULTURED_VS_FRESH_DN
0.05076 0.00000MOSERLE_IFNA_RESPONSE
0.08922 0.01920FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.12444 0.15750XU_HGF_TARGETS_INDUCED_BY_AKT1_6HR
0.08791 0.00222REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL
0.08159 0.08932VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.10503 0.04935LIAN_LIPA_TARGETS_3M
0.08028 0.00364GEISS_RESPONSE_TO_DSRNA_UP
0.03178 0.00700KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.19115 0.08380SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1
0.05900 0.04491BIOCARTA_GRANULOCYTES_PATHWAY
0.06150 0.00000CORUM_55S_RIBOSOME_MITOCHONDRIAL
0.13220 0.13180CHIANG_LIVER_CANCER_SUBCLASS_INTERFERON_UP
0.14386 0.00000WONG_EMBRYONIC_STEM_CELL_CORE
0.06104 0.14609ZHU_CMV_ALL_UP
0.05898 0.00199KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS
0.13418 0.00443KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00040 0.09323GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.06117 0.00108BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_UP