BICLUSTER_ID : UPREG-514
PATHOGENS /2/ : streptococcus gordonii,mycobacterium tuberculosis
TARGETS /9/ : S100A11, PSMB2, S100A1, JUN, LPL, TNFRSF1B, GRIA2, IFNB1, IL8
Gene SetLeading Edge Genes
NETPATH TNF ALPHA PATHWAY UPPSMB8, OPTN, GRIA2, PMAIP1, SLC39A1, NFKBIA, EGR1, PSME1, APOL3, EMP3, IFITM1, TMED1, S100A1, SEMA3E, CSF1, BCL3, FXR2, TNFSF10, IFITM3, CSTB, ATP6V1F, IRF1, IER2, NFKBIE, LPL, TMSB10, TNFRSF1B, RABAC1, S100A11, PPP1R15A, VRK2, PIGR, FAM50A, CACNG3, IFNB1, PRDX1, ZFP36, IL8, DUSP1
NCI NFAT TFPATHWAYIL4, EGR1, JUN, IL8, FOS, MAF
NCI HOST INTERACTIONS OF HIV FACTORSPSMB2, PSMB8, PSMD3, UBC, PSMB10, PSMD8, PSMB9, UBB, PSMD4, PSMF1, PSME1
NCI SCF SKP2 MEDIATED DEGRADATION OF P27 P21PSMB2, PSMB8, PSMD3, UBC, PSMB10, PSMD8, PSMB9, UBB, PSMD4, PSMF1, PSME1
NCI VPU MEDIATED DEGRADATION OF CD4PSMB2, PSMB8, PSMD3, UBC, PSMB10, PSMD8, PSMB9, UBB, PSMD4, PSMF1, PSME1
NCI UBIQUITIN DEPENDENT DEGRADATION OF CYCLIN D1PSMB2, PSMB8, PSMD4, UBC, PSME1, PSMB9
NCI SCF BETA TRCP MEDIATED DEGRADATION OF EMI1PSMB2, PSMB8, PSMD3, UBC, PSMB10, PSMD8, PSMB9, UBB, PSMD4, PSMF1, PSME1
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATION1PSMB2, PSMB8, PSMD3, UBC, PSMB10, PSMD8, PSMB9, UBB, PSMD4, PSMF1, PSME1
NCI VIF MEDIATED DEGRADATION OF APOBEC3GRBX1, PSMB2, PSMB8, PSMD3, UBC, PSMB10, PSMD8, PSMB9, UBB, PSMD4, PSMF1, PSME1
NCI DEGRADATION OF BETA CATENIN BY THE DESTRUCTION COMPLEXPSMB2, PSMB8, PSMD3, UBC, PSMB10, PSMD8, PSMB9, UBB, PSMD4, PSMF1, PSME1
NCI REGULATION OF ACTIVATED PAK 2P34 BY PROTEASOME MEDIATED DEGRADATIONPSMB2, PSMB8, PSMD3, UBC, PSMB10, PSMD8, PSMB9, UBB, PSMD4, PSMF1, PSME1
NCI UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25APSMB2, PSMB8, PSMD3, UBC, PSMB10, PSMD8, PSMB9, UBB, PSMD4, PSMF1, PSME1
NOJIMA SFRP2 TARGETS UP
NCI TCRCALCIUMPATHWAY
NCI ATF2 PATHWAY
AMIT EGF RESPONSE 40 HELA
MISHRA CARCINOMA ASSOCIATED FIBROBLAST UP
MAHADEVAN RESPONSE TO MP470 DN
CORUM ERG-JUN-FOS DNA-PROTEIN COMPLEX
AMIT EGF RESPONSE 20 HELA
DAZARD UV RESPONSE CLUSTER G3
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN
ENK UV RESPONSE KERATINOCYTE UP
TIAN TNF SIGNALING NOT VIA NFKB
VERRECCHIA RESPONSE TO TGFB1 C2
DIRMEIER LMP1 RESPONSE EARLY
RASHI RESPONSE TO IONIZING RADIATION 1
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP
SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP
GALE APL WITH FLT3 MUTATED DN
AMIT EGF RESPONSE 120 HELA
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN 2FC DN
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G
NCI CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6
LEE LIVER CANCER ACOX1 UP
MARTINEZ RESPONSE TO TRABECTEDIN UP
AMIT EGF RESPONSE 60 HELA
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN
DIRMEIER LMP1 RESPONSE LATE DN
CHEN HOXA5 TARGETS 9HR UP
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN
KEGG ALLOGRAFT REJECTION
AMIT SERUM RESPONSE 40 MCF10A
REACTOME P53 INDEPENDENT DNA DAMAGE RESPONSE
REACTOME GLYCOLYSIS
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP
SHI SPARC TARGETS UP
BROWNE HCMV INFECTION 2HR UP
NETPATH IL 3 PATHWAY DOWN
RODWELL AGING KIDNEY UP
SENESE HDAC1 TARGETS UP
BUDHU LIVER CANCER METASTASIS UP
BARRIER CANCER RELAPSE TUMOR SAMPLE DN
ONDER CDH1 TARGETS 1 DN
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
TIMOFEEVA GROWTH STRESS VIA STAT1 DN
MOOTHA GLUCONEOGENESIS
SA B CELL RECEPTOR COMPLEXES
DACOSTA UV RESPONSE VIA ERCC3 UP
HAMAI APOPTOSIS VIA TRAIL DN
TARTE PLASMA CELL VS PLASMABLAST UP
HESS TARGETS OF HOXA9 AND MEIS1 DN
CHASSOT SKIN WOUND
BIOCARTA TOLL PATHWAY
KEGG PROTEASOME
CREIGHTON AKT1 SIGNALING VIA MTOR DN
KRIGE AMINO ACID DEPRIVATION
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
streptococcus gordoniimycobacterium tuberculosisGeneSet Name
0.09153 0.00534NETPATH_TNF_ALPHA_PATHWAY_UP
0.00535 0.00205NCI_NFAT_TFPATHWAY
0.04140 0.00787NCI_HOST_INTERACTIONS_OF_HIV_FACTORS
0.04713 0.01422NCI_SCF_SKP2__MEDIATED_DEGRADATION_OF_P27_P21
0.06073 0.00707NCI_VPU_MEDIATED_DEGRADATION_OF_CD4
0.06446 0.00551NCI_UBIQUITIN_DEPENDENT_DEGRADATION_OF_CYCLIN_D1
0.05273 0.00570NCI_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1
0.08512 0.00809NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION1
0.05297 0.00789NCI_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
0.10002 0.00348NCI_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX
0.03663 0.00636NCI_REGULATION_OF_ACTIVATED_PAK_2P34_BY_PROTEASOME_MEDIATED_DEGRADATION
0.04176 0.01224NCI_UBIQUITIN_MEDIATED_DEGRADATION_OF_PHOSPHORYLATED_CDC25A
0.11488 0.00000NOJIMA_SFRP2_TARGETS_UP
0.17467 0.04081NCI_TCRCALCIUMPATHWAY
0.05399 0.06127NCI_ATF2_PATHWAY
0.12762 0.00000AMIT_EGF_RESPONSE_40_HELA
0.04229 0.01530MISHRA_CARCINOMA_ASSOCIATED_FIBROBLAST_UP
0.01276 0.00000MAHADEVAN_RESPONSE_TO_MP470_DN
0.13153 0.18526CORUM_ERG-JUN-FOS_DNA-PROTEIN_COMPLEX
0.00325 0.00486AMIT_EGF_RESPONSE_20_HELA
0.04761 0.02412DAZARD_UV_RESPONSE_CLUSTER_G3
0.09322 0.00089DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN
0.00354 0.00959ENK_UV_RESPONSE_KERATINOCYTE_UP
0.16748 0.00011TIAN_TNF_SIGNALING_NOT_VIA_NFKB
0.18777 0.02209VERRECCHIA_RESPONSE_TO_TGFB1_C2
0.11081 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.00215 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_1
0.17403 0.00469KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION
0.00393 0.08078NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP
0.19740 0.09738SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_UP
0.11091 0.00012FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP
0.09944 0.01882GALE_APL_WITH_FLT3_MUTATED_DN
0.00000 0.00000AMIT_EGF_RESPONSE_120_HELA
0.19933 0.03321SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_2FC_DN
0.15788 0.00468REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G
0.06071 0.03019NCI_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6
0.07371 0.00473LEE_LIVER_CANCER_ACOX1_UP
0.01363 0.01686MARTINEZ_RESPONSE_TO_TRABECTEDIN_UP
0.00000 0.00000AMIT_EGF_RESPONSE_60_HELA
0.15668 0.00008ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN
0.00051 0.05412DIRMEIER_LMP1_RESPONSE_LATE_DN
0.00000 0.00006CHEN_HOXA5_TARGETS_9HR_UP
0.05407 0.00008PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN
0.15904 0.00549KEGG_ALLOGRAFT_REJECTION
0.00519 0.00000AMIT_SERUM_RESPONSE_40_MCF10A
0.14389 0.01493REACTOME_P53_INDEPENDENT_DNA_DAMAGE_RESPONSE
0.03271 0.15713REACTOME_GLYCOLYSIS
0.00000 0.00001BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP
0.10486 0.11302SHI_SPARC_TARGETS_UP
0.02525 0.00000BROWNE_HCMV_INFECTION_2HR_UP
0.04616 0.09475NETPATH_IL_3_PATHWAY_DOWN
0.03419 0.00016RODWELL_AGING_KIDNEY_UP
0.00000 0.04425SENESE_HDAC1_TARGETS_UP
0.05267 0.05729BUDHU_LIVER_CANCER_METASTASIS_UP
0.04220 0.16260BARRIER_CANCER_RELAPSE_TUMOR_SAMPLE_DN
0.00000 0.07350ONDER_CDH1_TARGETS_1_DN
0.19653 0.00000UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.15037 0.19355TIMOFEEVA_GROWTH_STRESS_VIA_STAT1_DN
0.06712 0.17877MOOTHA_GLUCONEOGENESIS
0.14043 0.19472SA_B_CELL_RECEPTOR_COMPLEXES
0.07476 0.08987DACOSTA_UV_RESPONSE_VIA_ERCC3_UP
0.15902 0.04368HAMAI_APOPTOSIS_VIA_TRAIL_DN
0.05889 0.00261TARTE_PLASMA_CELL_VS_PLASMABLAST_UP
0.11349 0.00000HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.03039 0.00066CHASSOT_SKIN_WOUND
0.19597 0.00018BIOCARTA_TOLL_PATHWAY
0.15035 0.00367KEGG_PROTEASOME
0.00009 0.05494CREIGHTON_AKT1_SIGNALING_VIA_MTOR_DN
0.00320 0.00064KRIGE_AMINO_ACID_DEPRIVATION