BICLUSTER_ID : UPREG-58
PATHOGENS /6/ : pseudomonas aeruginosa,listeria monocytogenes,streptococcus pneumoniae,yersinia enterocolitica,helicobacter pylori,mycobacterium tuberculosis
TARGETS /3/ : NFKB1, IL6, PTGS2
Gene SetLeading Edge Genes
NETPATH IL 1 PATHWAY UPNFKB1, IL6, PTGS2, CXCL1, CXCL2
NETPATH TNF ALPHA PATHWAY DOWNMAFF, IL6, PTGS2, TNFAIP3, CXCL1, CXCL2
CHARAFE BREAST CANCER LUMINAL VS BASAL DN
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
LEONARD HYPOXIA
MAHAJAN RESPONSE TO IL1A UP
WEINMANN ADAPTATION TO HYPOXIA DN
LINDSTEDT DENDRITIC CELL MATURATION B
CROONQUIST STROMAL STIMULATION UP
RASHI RESPONSE TO IONIZING RADIATION 2
HALMOS CEBPA TARGETS UP
NETPATH IL 1 PATHWAY
LINDSTEDT DENDRITIC CELL MATURATION A
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL UP
ELVIDGE HYPOXIA UP
HORIUCHI WTAP TARGETS UP
IYENGAR RESPONSE TO ADIPOCYTE FACTORS
AMIT EGF RESPONSE 40 HELA
NETPATH IL 7 PATHWAY UP
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5
MAHADEVAN RESPONSE TO MP470 DN
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP
HARRIS HYPOXIA
DER IFN BETA RESPONSE UP
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP
HINATA NFKB TARGETS KERATINOCYTE UP
DIRMEIER LMP1 RESPONSE LATE UP
MARKEY RB1 ACUTE LOF UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
XU HGF TARGETS INDUCED BY AKT1 48HR UP
OSADA ASCL1 TARGETS DN
AMIT SERUM RESPONSE 60 MCF10A
MARZEC IL2 SIGNALING UP
NAGASHIMA NRG1 SIGNALING UP
SOUCEK MYC TARGETS
NUYTTEN EZH2 TARGETS UP
DUTTA APOPTOSIS VIA NFKB
ZERBINI RESPONSE TO SULINDAC UP
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS MAGENTA UP
HAN SATB1 TARGETS DN
CROMER TUMORIGENESIS UP
DIRMEIER LMP1 RESPONSE EARLY
FERRARI RESPONSE TO FENRETINIDE UP
SHAFFER IRF4 MULTIPLE MYELOMA PROGRAM
BILD HRAS ONCOGENIC SIGNATURE
ZHOU INFLAMMATORY RESPONSE LIVE UP
ONDER CDH1 TARGETS 3 DN
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP
AMIT EGF RESPONSE 120 HELA
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
BIOCARTA RANKL PATHWAY
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS
NETPATH IL 6 PATHWAY UPMAFF, GADD45B, CXCL1
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP
WINTER HYPOXIA METAGENE
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE
PODAR RESPONSE TO ADAPHOSTIN UP
BERENJENO TRANSFORMED BY RHOA FOREVER DN
DAZARD UV RESPONSE CLUSTER G2
CHEN HOXA5 TARGETS 9HR UP
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE UP
NETPATH IL 5 PATHWAY UP
FOSTER INFLAMMATORY RESPONSE LPS DN
TAVOR CEBPA TARGETS UP
SEKI INFLAMMATORY RESPONSE LPS UP
NETPATH EGFR1 PATHWAY UP
HELLER SILENCED BY METHYLATION UP
GRAHAM CML QUIESCENT VS CML DIVIDING UP
CONCANNON APOPTOSIS BY EPOXOMICIN UP
SATO SILENCED BY DEACETYLATION IN PANCREATIC CANCER
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP
SANA TNF SIGNALING UP
SENESE HDAC1 AND HDAC2 TARGETS UP
AMIT SERUM RESPONSE 120 MCF10A
WANG METHYLATED IN BREAST CANCER
BROWNE HCMV INFECTION 2HR UP
ONDER CDH1 TARGETS 2 DN
SENESE HDAC1 TARGETS UP
NCI IL1PATHWAY
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
KIM WT1 TARGETS UP
SENESE HDAC3 TARGETS UP
VERHAAK AML WITH NPM1 MUTATED UP
BROCKE APOPTOSIS REVERSED BY IL6
GEISS RESPONSE TO DSRNA UP
ONDER CDH1 TARGETS 1 DN
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
GERY CEBP TARGETS
NCI P53DOWNSTREAMPATHWAY
NCI NFKAPPABCANONICALPATHWAY
DASU IL6 SIGNALING UP
ELVIDGE HYPOXIA BY DMOG UP
TIAN TNF SIGNALING VIA NFKB
NETPATH IL 2 PATHWAY UP
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OKUMURA INFLAMMATORY RESPONSE LPS
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
BRUECKNER TARGETS OF MIRLET7A3 UP
KRIGE AMINO ACID DEPRIVATION
PRAMOONJAGO SOX4 TARGETS UP
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica wap bl6yersinia enterocolitica p60 bcpseudomonas aeruginosa fdr440streptococcus pneumoniae g54listeria monocytogenesmycobacterium tuberculosishelicobacter pylori kx2 mgepGeneSet Name
0.00024 0.00001 0.00000 0.02186 0.00000 0.00602 0.00000NETPATH_IL_1_PATHWAY_UP
0.00024 0.00000 0.01426 0.00809 0.00007 0.00002 0.00340NETPATH_TNF_ALPHA_PATHWAY_DOWN
0.10433 0.00028 0.00001 0.00034 0.00002 0.00002 0.05697CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN
0.00468 0.00145 0.00000 0.00810 0.00001 0.00000 0.00396MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00000 0.00000 0.00010 0.01878 0.00001 0.00000 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.05054 0.00508 0.01991 0.01189 0.00015 0.00000 0.06739SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP
0.00000 0.00000 0.01700 0.03257 0.00023 0.00002 0.00541GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.08551 0.02593 0.00131 0.00548 0.00328 0.01105 0.00000LEONARD_HYPOXIA
0.00113 0.00009 0.00044 0.08911 0.00046 0.00132 0.00001MAHAJAN_RESPONSE_TO_IL1A_UP
0.00024 0.00000 0.01567 0.00875 0.01186 0.03354 0.02716WEINMANN_ADAPTATION_TO_HYPOXIA_DN
0.04571 0.00237 0.00000 0.00817 0.00437 0.00000 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.04761 0.01017 0.00017 0.09861 0.05925 0.00025 0.05041CROONQUIST_STROMAL_STIMULATION_UP
0.00427 0.00008 0.00000 0.00271 0.04054 0.00000 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00185 0.00037 0.00031 0.02527 0.01542 0.01212 0.03870HALMOS_CEBPA_TARGETS_UP
0.04934 0.00206 0.00311 0.03624 0.00142 0.03544 0.00458NETPATH_IL_1_PATHWAY
0.00011 0.00000 0.00003 0.16372 0.00000 0.00000 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.03142 0.00171 0.00347 0.04813 0.00043 0.00196 0.02379LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_UP
0.00923 0.00036 0.16459 0.00034 0.00023 0.00052 0.00095ELVIDGE_HYPOXIA_UP
0.00735 0.00038 0.00881 0.00695 0.01805 0.00000 0.01380HORIUCHI_WTAP_TARGETS_UP
0.05090 0.00492 0.00064 0.03272 0.01417 0.00217 0.01339IYENGAR_RESPONSE_TO_ADIPOCYTE_FACTORS
0.01474 0.00031 0.15015 0.02615 0.00068 0.00000 0.00053AMIT_EGF_RESPONSE_40_HELA
0.00623 0.00028 0.00003 0.11486 0.09197 0.00856 0.00019NETPATH_IL_7_PATHWAY_UP
0.19093 0.14881 0.06558 0.03309 0.15820 0.05325 0.00313YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5
0.00031 0.00009 0.02760 0.15502 0.01146 0.00000 0.00005MAHADEVAN_RESPONSE_TO_MP470_DN
0.00024 0.00000 0.00052 0.09013 0.00000 0.00000 0.00010THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.01109 0.00004 0.11741 0.13995 0.00008 0.00000 0.09686TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP
0.00250 0.00029 0.00003 0.10031 0.00000 0.00067 0.00009HARRIS_HYPOXIA
0.04202 0.00056 0.00222 0.11870 0.00000 0.00000 0.12957DER_IFN_BETA_RESPONSE_UP
0.05961 0.00299 0.00448 0.01803 0.00000 0.00000 0.00012DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP
0.00000 0.00000 0.00000 0.00568 0.00001 0.00000 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.15215 0.00313 0.00027 0.06964 0.12444 0.00003 0.04267DIRMEIER_LMP1_RESPONSE_LATE_UP
0.00200 0.00004 0.01820 0.10730 0.00004 0.00000 0.09595MARKEY_RB1_ACUTE_LOF_UP
0.00045 0.00008 0.00034 0.17463 0.00736 0.00060 0.00019KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00003 0.00000 0.03498 0.00020 0.00000 0.01278BASSO_CD40_SIGNALING_UP
0.03329 0.02457 0.00999 0.18837 0.04325 0.00027 0.19637XU_HGF_TARGETS_INDUCED_BY_AKT1_48HR_UP
0.08327 0.06140 0.11392 0.03295 0.04416 0.00021 0.14030OSADA_ASCL1_TARGETS_DN
0.00000 0.00000 0.01060 0.00321 0.02234 0.00001 0.00000AMIT_SERUM_RESPONSE_60_MCF10A
0.00016 0.00008 0.01502 0.16651 0.00507 0.00127 0.01784MARZEC_IL2_SIGNALING_UP
0.00002 0.00000 0.00002 0.00022 0.00045 0.00000 0.00000NAGASHIMA_NRG1_SIGNALING_UP
0.00000 0.00008 0.02994 0.08229 0.09270 0.02521 0.00002SOUCEK_MYC_TARGETS
0.00615 0.00032 0.00021 0.00276 0.00000 0.00000 0.02487NUYTTEN_EZH2_TARGETS_UP
0.00646 0.00013 0.00513 0.05455 0.01422 0.00002 0.00000DUTTA_APOPTOSIS_VIA_NFKB
0.13677 0.12784 0.03840 0.09092 0.05033 0.04554 0.00100ZERBINI_RESPONSE_TO_SULINDAC_UP
0.19398 0.01191 0.04178 0.00558 0.00178 0.00022 0.04284GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_MAGENTA_UP
0.06100 0.00263 0.00625 0.04828 0.00346 0.00017 0.02340HAN_SATB1_TARGETS_DN
0.03004 0.00013 0.01404 0.02045 0.01616 0.01999 0.10547CROMER_TUMORIGENESIS_UP
0.00000 0.00000 0.00002 0.08905 0.00199 0.00000 0.00124DIRMEIER_LMP1_RESPONSE_EARLY
0.00508 0.00050 0.00002 0.01205 0.06128 0.00018 0.00002FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.01088 0.00353 0.15531 0.09034 0.00105 0.00240 0.01650SHAFFER_IRF4_MULTIPLE_MYELOMA_PROGRAM
0.00208 0.00000 0.00028 0.00093 0.00000 0.00000 0.00132BILD_HRAS_ONCOGENIC_SIGNATURE
0.00000 0.00000 0.00010 0.11282 0.00000 0.00002 0.00000ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00150 0.00099 0.00194 0.03102 0.00011 0.10086 0.00020ONDER_CDH1_TARGETS_3_DN
0.00200 0.00020 0.02769 0.01216 0.00000 0.00000 0.00044GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP
0.00077 0.00004 0.00068 0.01466 0.02592 0.00000 0.00007AMIT_EGF_RESPONSE_120_HELA
0.05660 0.02597 0.00085 0.03237 0.00016 0.00000 0.00008DAUER_STAT3_TARGETS_UP
0.00000 0.00000 0.00005 0.01216 0.00001 0.00000 0.00002LIANG_SILENCED_BY_METHYLATION_2
0.05455 0.01255 0.01277 0.11238 0.17317 0.03099 0.04291BIOCARTA_RANKL_PATHWAY
0.07010 0.00048 0.00016 0.16628 0.16188 0.00036 0.11815HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS
0.00000 0.00000 0.03716 0.01842 0.00233 0.00000 0.01969NETPATH_IL_6_PATHWAY_UP
0.10871 0.00659 0.01078 0.13119 0.01127 0.02002 0.00622NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.09112 0.06188 0.01555 0.00715 0.01810 0.00299 0.17266FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP
0.06926 0.00442 0.00135 0.01549 0.00186 0.00019 0.00315WINTER_HYPOXIA_METAGENE
0.00519 0.00857 0.09246 0.03041 0.01078 0.00911 0.07351SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE
0.00017 0.00001 0.13382 0.00016 0.00004 0.00000 0.00000PODAR_RESPONSE_TO_ADAPHOSTIN_UP
0.19546 0.00060 0.11486 0.02282 0.03353 0.08977 0.02345BERENJENO_TRANSFORMED_BY_RHOA_FOREVER_DN
0.11521 0.01385 0.00228 0.03619 0.04745 0.01541 0.00000DAZARD_UV_RESPONSE_CLUSTER_G2
0.01506 0.00074 0.00550 0.00050 0.00000 0.00006 0.00000CHEN_HOXA5_TARGETS_9HR_UP
0.00409 0.00001 0.12253 0.01570 0.00001 0.00000 0.00092GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_UP
0.02712 0.00159 0.00726 0.07746 0.00007 0.00000 0.00002NETPATH_IL_5_PATHWAY_UP
0.00000 0.00000 0.00037 0.01680 0.00001 0.00000 0.00146FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.15470 0.02930 0.08516 0.04868 0.00125 0.00011 0.04908TAVOR_CEBPA_TARGETS_UP
0.00000 0.00000 0.00000 0.02093 0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.04029 0.00205 0.00005 0.11210 0.03270 0.01945 0.07001NETPATH_EGFR1_PATHWAY_UP
0.00210 0.00028 0.01964 0.17361 0.07324 0.00000 0.08092HELLER_SILENCED_BY_METHYLATION_UP
0.00810 0.00030 0.00002 0.11160 0.00097 0.00000 0.00677GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00369 0.00226 0.03175 0.01005 0.00060 0.00028 0.00000CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP
0.04808 0.11465 0.01084 0.02405 0.03199 0.00117 0.15948SATO_SILENCED_BY_DEACETYLATION_IN_PANCREATIC_CANCER
0.00000 0.00000 0.00000 0.00231 0.00000 0.00000 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.09654 0.01041 0.06733 0.00031 0.00000 0.00001 0.00002BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP
0.00017 0.00000 0.00000 0.15203 0.00000 0.00000 0.00000SANA_TNF_SIGNALING_UP
0.02769 0.00026 0.00002 0.15156 0.00023 0.01303 0.00621SENESE_HDAC1_AND_HDAC2_TARGETS_UP
0.00013 0.00000 0.02960 0.00320 0.00040 0.00013 0.00109AMIT_SERUM_RESPONSE_120_MCF10A
0.00217 0.00032 0.06554 0.02474 0.17968 0.01939 0.01533WANG_METHYLATED_IN_BREAST_CANCER
0.06014 0.00673 0.00002 0.04469 0.02059 0.00000 0.00890BROWNE_HCMV_INFECTION_2HR_UP
0.00065 0.00011 0.00005 0.00297 0.00554 0.00500 0.01031ONDER_CDH1_TARGETS_2_DN
0.08354 0.00109 0.00013 0.05349 0.00009 0.04425 0.02102SENESE_HDAC1_TARGETS_UP
0.05191 0.01166 0.07208 0.18632 0.00886 0.01300 0.02503NCI_IL1PATHWAY
0.00080 0.00006 0.00011 0.00067 0.00000 0.00000 0.00008HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00757 0.00270 0.02538 0.01104 0.00002 0.00000 0.00018SESTO_RESPONSE_TO_UV_C3
0.01612 0.00000 0.00002 0.00273 0.01564 0.00007 0.00000KIM_WT1_TARGETS_UP
0.07491 0.00039 0.01005 0.03264 0.00256 0.00552 0.04896SENESE_HDAC3_TARGETS_UP
0.00001 0.00000 0.00218 0.12533 0.00000 0.00000 0.00145VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.01123 0.00068 0.04896 0.09635 0.00001 0.00000 0.00158BROCKE_APOPTOSIS_REVERSED_BY_IL6
0.00179 0.00000 0.00007 0.03258 0.00027 0.00000 0.00000GEISS_RESPONSE_TO_DSRNA_UP
0.07697 0.01007 0.00709 0.07758 0.00003 0.07350 0.00512ONDER_CDH1_TARGETS_1_DN
0.00000 0.00000 0.02749 0.00000 0.00007 0.00000 0.00000UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.00277 0.00510 0.00131 0.12493 0.00163 0.00000 0.00038GERY_CEBP_TARGETS
0.08860 0.13034 0.02164 0.06541 0.14599 0.08955 0.11095NCI_P53DOWNSTREAMPATHWAY
0.11497 0.04547 0.01645 0.05639 0.01014 0.00572 0.01694NCI_NFKAPPABCANONICALPATHWAY
0.01073 0.00020 0.00711 0.09369 0.00595 0.00006 0.10056DASU_IL6_SIGNALING_UP
0.01114 0.00017 0.15685 0.00018 0.00142 0.00043 0.00024ELVIDGE_HYPOXIA_BY_DMOG_UP
0.00000 0.00000 0.00000 0.16057 0.00054 0.00000 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.01769 0.00018 0.00843 0.16635 0.00068 0.00008 0.04909NETPATH_IL_2_PATHWAY_UP
0.00024 0.00000 0.00000 0.03864 0.00001 0.00002 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.09623 0.00041 0.01148 0.04102 0.00777 0.04117 0.14096OKUMURA_INFLAMMATORY_RESPONSE_LPS
0.00000 0.00000 0.00011 0.01851 0.00001 0.00000 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00139 0.00168 0.00243 0.06587 0.02848 0.13990 0.10358LEE_LIVER_CANCER_HEPATOBLAST
0.08451 0.05022 0.00002 0.01824 0.00518 0.00039 0.00076ZUCCHI_METASTASIS_DN
0.00000 0.00000 0.00002 0.00045 0.00001 0.00000 0.00000NAGASHIMA_EGF_SIGNALING_UP
0.16977 0.00209 0.12920 0.00087 0.00484 0.06983 0.13584BRUECKNER_TARGETS_OF_MIRLET7A3_UP
0.09096 0.01120 0.08532 0.04467 0.15378 0.00064 0.00000KRIGE_AMINO_ACID_DEPRIVATION
0.02502 0.00119 0.00044 0.00000 0.01526 0.00000 0.00000PRAMOONJAGO_SOX4_TARGETS_UP
0.00000 0.00000 0.06556 0.00267 0.00887 0.00000 0.00000PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN
0.03435 0.00008 0.00000 0.02432 0.00031 0.00000 0.00009HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00000 0.00000 0.00027 0.00090 0.01523 0.00004 0.00000AMIT_EGF_RESPONSE_60_MCF10A