BICLUSTER_ID : UPREG-66
PATHOGENS /5/ : escherichia coli,bifidobacterium bifidum,yersinia enterocolitica,aeromonas caviae,ehrlichia chaffeensis
TARGETS /1/ : TNF
Gene SetLeading Edge Genes
NETPATH IL 4 PATHWAY DOWNGEM, IRF1, MX1, TNF, GBP2
NCI IL23PATHWAYSOCS3, CXCL1, TNF
NCI IL27PATHWAYTNF
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
NETPATH IL 9 PATHWAY UPSOCS3
MAHAJAN RESPONSE TO IL1A UP
ZHANG INTERFERON RESPONSE
CHANG IMMORTALIZED BY HPV31 DN
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP
AUJLA IL22 AND IL17A SIGNALING
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
REACTOME PEPTIDE LIGAND BINDING RECEPTORS
LINDSTEDT DENDRITIC CELL MATURATION B
KRASNOSELSKAYA ILF3 TARGETS UP
SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN
LINDSTEDT DENDRITIC CELL MATURATION A
RADAEVA RESPONSE TO IFNA1 UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP
WALLACE PROSTATE CANCER RACE UP
KIM LRRC3B TARGETS
HORIUCHI WTAP TARGETS UP
BOWIE RESPONSE TO EXTRACELLULAR MATRIX
NETPATH IL 7 PATHWAY UPCXCL1
BIOCARTA NKT PATHWAY
UROSEVIC RESPONSE TO IMIQUIMOD
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 DN
BROWNE INTERFERON RESPONSIVE GENES
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP
KEGG JAK STAT SIGNALING PATHWAY
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN
ROETH TERT TARGETS UP
DER IFN BETA RESPONSE UP
TSAI DNAJB4 TARGETS UP
HINATA NFKB TARGETS KERATINOCYTE UP
MARKEY RB1 ACUTE LOF UP
BASSO CD40 SIGNALING UP
XU AKT1 TARGETS 6HR
SOUCEK MYC TARGETS
BIOCARTA DC PATHWAY
NUYTTEN EZH2 TARGETS UP
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION
MAHADEVAN RESPONSE TO MP470 UP
ZHAN MULTIPLE MYELOMA LB DN
SMID BREAST CANCER NORMAL LIKE UP
KEGG AUTOIMMUNE THYROID DISEASE
LIU VAV3 PROSTATE CARCINOGENESIS UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS
SHAFFER IRF4 MULTIPLE MYELOMA PROGRAM
SANA RESPONSE TO IFNG UP
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP
NETPATH IL 3 PATHWAY UPSOCS3, SOCS1
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP
KEGG LEISHMANIA INFECTION
NETPATH IL 6 PATHWAY UPSOCS3, CXCL1, SOCS1, IRF1, MAP3K8, MX1
MCLACHLAN DENTAL CARIES UP
DER IFN ALPHA RESPONSE UP
BOYLAN MULTIPLE MYELOMA PCA1 UP
EINAV INTERFERON SIGNATURE IN CANCER
NETPATH IL 5 PATHWAY UPUPP1, CASP4
MCLACHLAN DENTAL CARIES DN
LEE LIVER CANCER E2F1 UP
FOSTER INFLAMMATORY RESPONSE LPS DN
KEGG ALLOGRAFT REJECTION
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
NETPATH IL 4 PATHWAY UPSOCS3, IL1RN, IBRDC3, SOCS1, CH25H, UPP1, IL10
HELLER SILENCED BY METHYLATION UP
GRANDVAUX IFN RESPONSE NOT VIA IRF3
FARMER BREAST CANCER CLUSTER 1
BOWIE RESPONSE TO TAMOXIFEN
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHU CMV 8 HR UP
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP
SMID BREAST CANCER LUMINAL B DN
ZHOU INFLAMMATORY RESPONSE LPS UP
NOJIMA SFRP2 TARGETS DN
SANA TNF SIGNALING UP
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP
MOSERLE IFNA RESPONSE
FURUKAWA DUSP6 TARGETS PCI35 UP
FOSTER INFLAMMATORY RESPONSE LPS UP
BIOCARTA ASBCELL PATHWAY
XU HGF TARGETS INDUCED BY AKT1 6HR
LEE LIVER CANCER MYC E2F1 UP
CASTELLANO NRAS TARGETS UP
VERHAAK AML WITH NPM1 MUTATED UP
KEGG CHEMOKINE SIGNALING PATHWAY
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1
JISON SICKLE CELL DISEASE UP
BIOCARTA GRANULOCYTES PATHWAY
NETPATH IL 2 PATHWAY
NCI IL12 2PATHWAYSOCS1
HESS TARGETS OF HOXA9 AND MEIS1 DN
ZHU CMV ALL UP
NETPATH IL 2 PATHWAY UPIFIT1, TRIM21, IL10, SOCS3, TRAFD1, SOCS1, PBEF1, IRF1, UPP1, MX1
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
LU IL4 SIGNALING
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica wap bl6ehrlichia chaffeensis arkansayersinia enterocolitica p60 bl6yersinia enterocolitica p60 bcbifidobacterium bifidumaeromonas caviaescherichia coliGeneSet Name
0.00145 0.00001 0.00146 0.00040 0.00103 0.01190 0.00000NETPATH_IL_4_PATHWAY_DOWN
0.00000 0.00000 0.00000 0.00000 0.00000 0.00704 0.00000NCI_IL23PATHWAY
0.02027 0.00000 0.02901 0.00318 0.00000 0.00317 0.00000NCI_IL27PATHWAY
0.00000 0.00000 0.00000 0.00000 0.00000 0.01697 0.00000KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00000 0.00021 0.00021 0.00000 0.00214 0.01924 0.00000GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00016 0.00097 0.00016 0.00009 0.00572 0.07320 0.00028NETPATH_IL_9_PATHWAY_UP
0.00113 0.01198 0.00010 0.00009 0.00474 0.16652 0.00000MAHAJAN_RESPONSE_TO_IL1A_UP
0.00001 0.00000 0.00037 0.00013 0.00000 0.00003 0.00000ZHANG_INTERFERON_RESPONSE
0.09883 0.00135 0.03094 0.00008 0.08520 0.03023 0.00015CHANG_IMMORTALIZED_BY_HPV31_DN
0.00000 0.00000 0.00007 0.00000 0.00117 0.00143 0.00009TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP
0.01525 0.00697 0.00953 0.00824 0.00419 0.01459 0.00129AUJLA_IL22_AND_IL17A_SIGNALING
0.00000 0.00000 0.00011 0.00000 0.00000 0.00000 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.00006 0.00094 0.00054 0.00005 0.01762 0.13954 0.00015REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS
0.04571 0.00007 0.04591 0.00237 0.00000 0.00053 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00249 0.00016 0.00309 0.00020 0.13661 0.00214 0.00000KRASNOSELSKAYA_ILF3_TARGETS_UP
0.02304 0.03916 0.00042 0.04185 0.00360 0.05537 0.04442SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_DN
0.00011 0.00000 0.00029 0.00000 0.00005 0.00124 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00075 0.00000 0.00709 0.00008 0.00000 0.00000 0.00000RADAEVA_RESPONSE_TO_IFNA1_UP
0.00023 0.00001 0.00069 0.00000 0.00005 0.00001 0.00000TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP
0.00001 0.00000 0.00029 0.00000 0.00167 0.00000 0.00004WALLACE_PROSTATE_CANCER_RACE_UP
0.01705 0.00000 0.03216 0.00041 0.00007 0.00000 0.00004KIM_LRRC3B_TARGETS
0.00735 0.00147 0.01137 0.00038 0.00296 0.12653 0.00002HORIUCHI_WTAP_TARGETS_UP
0.00289 0.00254 0.00618 0.00683 0.00216 0.00058 0.00001BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX
0.00623 0.00034 0.00709 0.00028 0.01764 0.16616 0.00000NETPATH_IL_7_PATHWAY_UP
0.02499 0.00005 0.13260 0.03708 0.03302 0.18798 0.00003BIOCARTA_NKT_PATHWAY
0.00114 0.00000 0.00167 0.00028 0.00005 0.00001 0.00000UROSEVIC_RESPONSE_TO_IMIQUIMOD
0.07134 0.00000 0.00504 0.01065 0.11419 0.00603 0.00220CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN
0.00000 0.00000 0.00006 0.00000 0.00000 0.00000 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.00000 0.00000 0.00000 0.00000 0.00000 0.00000 0.00000TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP
0.00005 0.01019 0.00111 0.00015 0.00000 0.00316 0.00009KEGG_JAK_STAT_SIGNALING_PATHWAY
0.01109 0.00081 0.00708 0.00004 0.00139 0.16527 0.00220TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP
0.00700 0.00000 0.02263 0.00008 0.00457 0.00001 0.00002FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN
0.05386 0.01826 0.09575 0.00741 0.00294 0.00363 0.00141ROETH_TERT_TARGETS_UP
0.04202 0.00030 0.04762 0.00056 0.02261 0.00003 0.00000DER_IFN_BETA_RESPONSE_UP
0.03172 0.01306 0.06839 0.02491 0.02695 0.01036 0.01475TSAI_DNAJB4_TARGETS_UP
0.00000 0.00055 0.00000 0.00000 0.00013 0.06206 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00200 0.00000 0.01647 0.00004 0.00000 0.00000 0.00000MARKEY_RB1_ACUTE_LOF_UP
0.00000 0.00000 0.00018 0.00003 0.00006 0.00110 0.00000BASSO_CD40_SIGNALING_UP
0.00299 0.00698 0.00129 0.00049 0.00292 0.01113 0.00144XU_AKT1_TARGETS_6HR
0.00000 0.00003 0.00018 0.00008 0.00012 0.00169 0.00037SOUCEK_MYC_TARGETS
0.00606 0.00147 0.04231 0.04900 0.00573 0.01876 0.00672BIOCARTA_DC_PATHWAY
0.00615 0.00475 0.00356 0.00032 0.00779 0.07444 0.00000NUYTTEN_EZH2_TARGETS_UP
0.00646 0.00000 0.00201 0.00013 0.00215 0.05340 0.00000DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.00000 0.00018 0.00000 0.00294 0.00564 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.10664 0.00899 0.13918 0.13189 0.00179 0.07861 0.00010KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION
0.00025 0.00029 0.00018 0.00000 0.00318 0.00240 0.00000MAHADEVAN_RESPONSE_TO_MP470_UP
0.00434 0.00000 0.02608 0.00021 0.01616 0.00000 0.00002ZHAN_MULTIPLE_MYELOMA_LB_DN
0.00889 0.00000 0.01677 0.09807 0.17152 0.00209 0.13855SMID_BREAST_CANCER_NORMAL_LIKE_UP
0.01336 0.01760 0.01127 0.11422 0.00055 0.04468 0.00009KEGG_AUTOIMMUNE_THYROID_DISEASE
0.02669 0.00000 0.12805 0.08100 0.10808 0.00001 0.00647LIU_VAV3_PROSTATE_CARCINOGENESIS_UP
0.00002 0.00000 0.00012 0.00000 0.00006 0.00008 0.00000REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.00018 0.00001 0.00069 0.00000 0.00442 0.00003 0.00000SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP
0.00001 0.00000 0.00079 0.00003 0.00000 0.00041 0.00000BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS
0.01088 0.14892 0.00394 0.00353 0.00315 0.14256 0.00249SHAFFER_IRF4_MULTIPLE_MYELOMA_PROGRAM
0.00068 0.00000 0.01462 0.00000 0.00000 0.00000 0.00000SANA_RESPONSE_TO_IFNG_UP
0.19163 0.00123 0.06839 0.05249 0.08197 0.11676 0.01985RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP
0.00000 0.00000 0.00000 0.00000 0.01084 0.00216 0.00000NETPATH_IL_3_PATHWAY_UP
0.05660 0.01097 0.06189 0.02597 0.00011 0.05120 0.00003DAUER_STAT3_TARGETS_UP
0.00000 0.00001 0.00000 0.00000 0.00000 0.00001 0.00000LIANG_SILENCED_BY_METHYLATION_2
0.03866 0.00000 0.02528 0.08621 0.13644 0.00001 0.04537NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP
0.00675 0.00000 0.07814 0.01693 0.00573 0.05933 0.00028KEGG_LEISHMANIA_INFECTION
0.00000 0.00003 0.00000 0.00000 0.00007 0.10211 0.00000NETPATH_IL_6_PATHWAY_UP
0.00049 0.00000 0.00050 0.00008 0.00155 0.00003 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.06470 0.00000 0.14030 0.00389 0.00081 0.00000 0.00000DER_IFN_ALPHA_RESPONSE_UP
0.00018 0.00000 0.00219 0.09493 0.11977 0.00286 0.05581BOYLAN_MULTIPLE_MYELOMA_PCA1_UP
0.09928 0.00023 0.06958 0.00009 0.00000 0.00000 0.00000EINAV_INTERFERON_SIGNATURE_IN_CANCER
0.02712 0.00007 0.00711 0.00159 0.11144 0.07327 0.00001NETPATH_IL_5_PATHWAY_UP
0.00078 0.00000 0.00065 0.00014 0.00444 0.00003 0.00002MCLACHLAN_DENTAL_CARIES_DN
0.00381 0.00000 0.00563 0.00219 0.00724 0.01675 0.00843LEE_LIVER_CANCER_E2F1_UP
0.00000 0.00000 0.00000 0.00000 0.00000 0.00001 0.00000FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00363 0.00009 0.00288 0.01133 0.00011 0.01652 0.00000KEGG_ALLOGRAFT_REJECTION
0.00000 0.00000 0.00000 0.00000 0.00000 0.00002 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00000 0.00000 0.00007 0.00001 0.00000GAURNIER_PSMD4_TARGETS
0.00016 0.00011 0.00010 0.00000 0.05727 0.03395 0.00129NETPATH_IL_4_PATHWAY_UP
0.00210 0.00000 0.00251 0.00028 0.02743 0.00206 0.00002HELLER_SILENCED_BY_METHYLATION_UP
0.00158 0.00010 0.00375 0.00097 0.00064 0.00003 0.00002GRANDVAUX_IFN_RESPONSE_NOT_VIA_IRF3
0.00492 0.00000 0.00711 0.00039 0.00019 0.00001 0.00000FARMER_BREAST_CANCER_CLUSTER_1
0.00150 0.00015 0.00593 0.00077 0.00013 0.00004 0.00000BOWIE_RESPONSE_TO_TAMOXIFEN
0.00000 0.00000 0.00000 0.00000 0.00000 0.00001 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00025 0.00000 0.00061 0.00000 0.00006 0.00058 0.00000ZHU_CMV_8_HR_UP
0.00000 0.00000 0.00015 0.00218 0.00865 0.00000 0.00769ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP
0.00087 0.00000 0.00018 0.00148 0.13028 0.08643 0.00006SMID_BREAST_CANCER_LUMINAL_B_DN
0.00000 0.00269 0.00000 0.00000 0.00000 0.01590 0.00000ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00066 0.00573 0.01777 0.00097 0.05582 0.00332 0.00025NOJIMA_SFRP2_TARGETS_DN
0.00017 0.00000 0.00022 0.00000 0.00000 0.00000 0.00000SANA_TNF_SIGNALING_UP
0.00116 0.00104 0.00043 0.00000 0.00019 0.00109 0.00000TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP
0.00044 0.00000 0.00236 0.00000 0.00000 0.00000 0.00000MOSERLE_IFNA_RESPONSE
0.07691 0.07466 0.16226 0.17340 0.05128 0.01918 0.06057FURUKAWA_DUSP6_TARGETS_PCI35_UP
0.00000 0.00000 0.00004 0.00000 0.00000 0.01920 0.00011FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.04816 0.00639 0.12689 0.13527 0.00436 0.04179 0.00194BIOCARTA_ASBCELL_PATHWAY
0.01150 0.03408 0.02501 0.02068 0.04693 0.15750 0.00014XU_HGF_TARGETS_INDUCED_BY_AKT1_6HR
0.00469 0.00000 0.00848 0.01117 0.02392 0.01790 0.08000LEE_LIVER_CANCER_MYC_E2F1_UP
0.00165 0.00014 0.00019 0.00041 0.00034 0.02086 0.00040CASTELLANO_NRAS_TARGETS_UP
0.00001 0.00000 0.00000 0.00000 0.02011 0.08932 0.00000VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.04586 0.00000 0.06209 0.00858 0.10844 0.01801 0.00217KEGG_CHEMOKINE_SIGNALING_PATHWAY
0.00179 0.00175 0.00109 0.00000 0.00426 0.00364 0.00000GEISS_RESPONSE_TO_DSRNA_UP
0.00145 0.01044 0.00200 0.00805 0.00006 0.00700 0.00000KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00514 0.00015 0.00272 0.00007 0.00145 0.00399 0.00000GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN
0.00093 0.00221 0.00070 0.00226 0.14936 0.08380 0.00653SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1
0.06052 0.00000 0.06359 0.00209 0.00331 0.00632 0.00023JISON_SICKLE_CELL_DISEASE_UP
0.03005 0.00024 0.01449 0.00695 0.01849 0.04491 0.15379BIOCARTA_GRANULOCYTES_PATHWAY
0.14219 0.06588 0.10305 0.09647 0.08923 0.05436 0.01452NETPATH_IL_2_PATHWAY
0.00709 0.00000 0.00272 0.00140 0.00033 0.00545 0.00000NCI_IL12_2PATHWAY
0.00000 0.00000 0.00006 0.00004 0.09533 0.01035 0.08966HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.02045 0.00053 0.03630 0.00004 0.03180 0.14609 0.00000ZHU_CMV_ALL_UP
0.01769 0.00029 0.00994 0.00018 0.07512 0.07215 0.00000NETPATH_IL_2_PATHWAY_UP
0.00027 0.00000 0.01680 0.00219 0.00000 0.00443 0.00000KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00024 0.00001 0.00037 0.00000 0.00000 0.09323 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00017 0.00276 0.00176 0.00004 0.01831 0.01920 0.00649LU_IL4_SIGNALING