BICLUSTER_ID : UPREG-70
PATHOGENS /7/ : pseudomonas aeruginosa,listeria monocytogenes,bacillus anthracis,escherichia coli,yersinia enterocolitica,mycobacterium tuberculosis,shigella dysenteriae
TARGETS /4/ : NFKB1, PTGS2, TNF, PLAUR
Gene SetLeading Edge Genes
NETPATH IL 2 PATHWAY UPNFKB1, B4GALT5, KLF6, GADD45G, PLAUR, CCL4, TNF
NETPATH IL 1 PATHWAY UPNFKB1, PTGS2, CXCL1, CXCL2, CCL4
NETPATH TNF ALPHA PATHWAY DOWNKLF6, PTGS2, TNFAIP3, CXCL1, CXCL2
GERY CEBP TARGETSCXCL1, GADD45G, PLAUR, DUSP1
NOJIMA SFRP2 TARGETS UP
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
BIOCARTA NFKB PATHWAY
MAHAJAN RESPONSE TO IL1A UP
DORN ADENOVIRUS INFECTION 32HR DN
LINDSTEDT DENDRITIC CELL MATURATION B
CROONQUIST STROMAL STIMULATION UP
BIOCARTA IL1R PATHWAY
SA MMP CYTOKINE CONNECTION
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
NETPATH IL 1 PATHWAY
SIMBULAN UV RESPONSE NORMAL UP
KIM LRRC3B TARGETS
AMIT EGF RESPONSE 40 HELA
NETPATH IL 4 PATHWAY DOWN
NETPATH IL 7 PATHWAY UP
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5
MAHADEVAN RESPONSE TO MP470 DN
THEILGAARD NEUTROPHIL AT SKIN WOUND UP
NETPATH KIT RECEPTOR PATHWAY UP
HARRIS HYPOXIA
HINATA NFKB TARGETS KERATINOCYTE UP
AMIT EGF RESPONSE 20 HELA
DORN ADENOVIRUS INFECTION 48HR DN
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
TIAN TNF SIGNALING NOT VIA NFKB
AMIT SERUM RESPONSE 60 MCF10A
NAGASHIMA NRG1 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
DIRMEIER LMP1 RESPONSE EARLY
MAHADEVAN RESPONSE TO MP470 UP
FERRARI RESPONSE TO FENRETINIDE UP
BILD HRAS ONCOGENIC SIGNATURE
NCI NFAT TFPATHWAY
ZHOU INFLAMMATORY RESPONSE LIVE UP
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP
NETPATH IL 3 PATHWAY UPCCL4
AMIT EGF RESPONSE 120 HELA
DAUER STAT3 TARGETS UP
BIOCARTA RANKL PATHWAY
KEGG LEISHMANIA INFECTION
WINTER HYPOXIA METAGENE
DAZARD RESPONSE TO UV NHEK UP
MCLACHLAN DENTAL CARIES UP
NCI NF KB IS ACTIVATED AND SIGNALS SURVIVAL
AMIT EGF RESPONSE 60 HELA
DAZARD UV RESPONSE CLUSTER G2
NETPATH IL 5 PATHWAY UP
FOSTER INFLAMMATORY RESPONSE LPS DN
MCLACHLAN DENTAL CARIES DN
SEKI INFLAMMATORY RESPONSE LPS UP
AMIT SERUM RESPONSE 40 MCF10A
GAURNIER PSMD4 TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
NCI IL23PATHWAY
ZHOU INFLAMMATORY RESPONSE LPS UP
GESERICK TERT TARGETS DN
SANA TNF SIGNALING UP
WANG METHYLATED IN BREAST CANCER
BROWNE HCMV INFECTION 2HR UP
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
SESTO RESPONSE TO UV C3
KIM WT1 TARGETS UP
VERHAAK AML WITH NPM1 MUTATED UP
REACTOME P75NTR SIGNALS VIA NFKB
GEISS RESPONSE TO DSRNA UP
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
KOBAYASHI EGFR SIGNALING 6HR DN
CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX RPL6 RPL30 RPS13 CHUK DDX3X NFKB2 NFKBIB REL IKBKG NFKB1 MAP3K8 RELB GLG1 NFKBIA RELA TNIP2 GTF2I
ZHOU INFLAMMATORY RESPONSE FIMA UP
NCI NFKAPPABCANONICALPATHWAYTNFAIP3, RIPK2
HESS TARGETS OF HOXA9 AND MEIS1 DN
AMIT EGF RESPONSE 120 MCF10A
TIAN TNF SIGNALING VIA NFKB
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
PRAMOONJAGO SOX4 TARGETS UP
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica wap bl6yersinia enterocolitica wap bclisteria monocytogenespseudomonas aeruginosabacillus anthracismycobacterium tuberculosisescherichia colishigella dysenteriaeGeneSet Name
0.01769 0.00010 0.00068 0.11013 0.18345 0.00008 0.00000 0.08636NETPATH_IL_2_PATHWAY_UP
0.00024 0.00001 0.00000 0.00004 0.00738 0.00602 0.00000 0.00030NETPATH_IL_1_PATHWAY_UP
0.00024 0.00000 0.00007 0.00764 0.03274 0.00002 0.00002 0.00000NETPATH_TNF_ALPHA_PATHWAY_DOWN
0.00277 0.00013 0.00163 0.00843 0.01488 0.00000 0.01389 0.00067GERY_CEBP_TARGETS
0.00172 0.00224 0.02668 0.06631 0.00004 0.00000 0.00018 0.00035NOJIMA_SFRP2_TARGETS_UP
0.00468 0.00107 0.00001 0.00002 0.06111 0.00000 0.00000 0.00484MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00000 0.00000 0.00001 0.00003 0.01784 0.00000 0.00000 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00000 0.00000 0.00023 0.01558 0.15911 0.00002 0.00000 0.00252GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.11451 0.01359 0.08391 0.04067 0.09838 0.00073 0.00000 0.01398BIOCARTA_NFKB_PATHWAY
0.00113 0.00000 0.00046 0.00000 0.01475 0.00132 0.00000 0.00316MAHAJAN_RESPONSE_TO_IL1A_UP
0.13670 0.01879 0.01095 0.00267 0.05861 0.00008 0.00003 0.00014DORN_ADENOVIRUS_INFECTION_32HR_DN
0.04571 0.00004 0.00437 0.00005 0.00000 0.00000 0.00000 0.00053LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.04761 0.00829 0.05925 0.01456 0.03531 0.00025 0.00003 0.00808CROONQUIST_STROMAL_STIMULATION_UP
0.00017 0.00011 0.00776 0.02041 0.00016 0.00118 0.00000 0.00825BIOCARTA_IL1R_PATHWAY
0.00406 0.00860 0.04438 0.04053 0.15130 0.00814 0.00133 0.10485SA_MMP_CYTOKINE_CONNECTION
0.00427 0.00001 0.04054 0.00000 0.00554 0.00000 0.00000 0.00004RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00011 0.00000 0.00000 0.00387 0.00000 0.00000 0.00000 0.00034LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.04934 0.00093 0.00142 0.00603 0.15756 0.03544 0.00003 0.02164NETPATH_IL_1_PATHWAY
0.11226 0.00821 0.04183 0.00361 0.13030 0.04602 0.01024 0.03162SIMBULAN_UV_RESPONSE_NORMAL_UP
0.01705 0.00014 0.00001 0.03852 0.15773 0.00000 0.00004 0.07873KIM_LRRC3B_TARGETS
0.01474 0.00018 0.00068 0.00000 0.00021 0.00000 0.00000 0.00000AMIT_EGF_RESPONSE_40_HELA
0.00145 0.00024 0.00001 0.00000 0.12825 0.00000 0.00000 0.16501NETPATH_IL_4_PATHWAY_DOWN
0.00623 0.00052 0.09197 0.00151 0.04896 0.00856 0.00000 0.04120NETPATH_IL_7_PATHWAY_UP
0.19093 0.01552 0.15820 0.00150 0.02634 0.05325 0.03327 0.02126YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5
0.00031 0.00006 0.01146 0.00187 0.19442 0.00000 0.00317 0.00000MAHADEVAN_RESPONSE_TO_MP470_DN
0.00024 0.00000 0.00000 0.00381 0.00240 0.00000 0.00000 0.00000THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP
0.00062 0.00004 0.05671 0.05123 0.01116 0.00019 0.00023 0.00112NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00250 0.00004 0.00000 0.00391 0.07884 0.00067 0.00034 0.00501HARRIS_HYPOXIA
0.00000 0.00000 0.00001 0.00000 0.00000 0.00000 0.00000 0.00078HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.16753 0.06004 0.02894 0.00091 0.14256 0.00486 0.00089 0.00013AMIT_EGF_RESPONSE_20_HELA
0.19614 0.01624 0.00579 0.00817 0.18980 0.00008 0.00089 0.00056DORN_ADENOVIRUS_INFECTION_48HR_DN
0.00045 0.00000 0.00736 0.00004 0.00215 0.00060 0.00000 0.00096KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00000 0.00020 0.00006 0.00000 0.00000 0.00000 0.00004BASSO_CD40_SIGNALING_UP
0.01664 0.00034 0.01298 0.05837 0.08646 0.00011 0.00702 0.00005TIAN_TNF_SIGNALING_NOT_VIA_NFKB
0.00000 0.00000 0.02234 0.00092 0.17556 0.00001 0.00109 0.00000AMIT_SERUM_RESPONSE_60_MCF10A
0.00002 0.00000 0.00045 0.00113 0.00590 0.00000 0.00000 0.00000NAGASHIMA_NRG1_SIGNALING_UP
0.00000 0.00001 0.09270 0.00251 0.00345 0.02521 0.00037 0.02047SOUCEK_MYC_TARGETS
0.00646 0.00003 0.01422 0.00086 0.01600 0.00002 0.00000 0.02611DUTTA_APOPTOSIS_VIA_NFKB
0.00000 0.00000 0.00199 0.00000 0.00000 0.00000 0.00000 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.00025 0.00006 0.00004 0.00009 0.00593 0.00004 0.00000 0.06328MAHADEVAN_RESPONSE_TO_MP470_UP
0.00508 0.00007 0.06128 0.00003 0.01068 0.00018 0.00016 0.00712FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00208 0.00000 0.00000 0.00110 0.13675 0.00000 0.00000 0.00000BILD_HRAS_ONCOGENIC_SIGNATURE
0.06500 0.00259 0.05773 0.13386 0.09949 0.00205 0.00004 0.00077NCI_NFAT_TFPATHWAY
0.00000 0.00000 0.00000 0.00000 0.00000 0.00002 0.00000 0.00006ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP
0.00200 0.00000 0.00000 0.01100 0.02051 0.00000 0.00155 0.00009GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP
0.00000 0.00000 0.00553 0.01596 0.19023 0.00171 0.00000 0.00147NETPATH_IL_3_PATHWAY_UP
0.00077 0.00000 0.02592 0.00184 0.08697 0.00000 0.00046 0.00113AMIT_EGF_RESPONSE_120_HELA
0.05660 0.06147 0.00016 0.00006 0.00062 0.00000 0.00003 0.00005DAUER_STAT3_TARGETS_UP
0.05455 0.02104 0.17317 0.01532 0.02228 0.03099 0.05932 0.15704BIOCARTA_RANKL_PATHWAY
0.00675 0.00695 0.00055 0.00366 0.01847 0.00007 0.00028 0.00317KEGG_LEISHMANIA_INFECTION
0.06926 0.00004 0.00186 0.10229 0.14321 0.00019 0.02164 0.04655WINTER_HYPOXIA_METAGENE
0.08717 0.00323 0.01225 0.00080 0.15309 0.00196 0.00002 0.00111DAZARD_RESPONSE_TO_UV_NHEK_UP
0.00049 0.00000 0.00000 0.00000 0.11704 0.00000 0.00000 0.01598MCLACHLAN_DENTAL_CARIES_UP
0.19793 0.11013 0.07063 0.00190 0.01077 0.03247 0.00474 0.04605NCI_NF_KB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL
0.02663 0.00000 0.02795 0.17983 0.18300 0.00000 0.00523 0.00007AMIT_EGF_RESPONSE_60_HELA
0.11521 0.00772 0.04745 0.01158 0.15429 0.01541 0.00004 0.00032DAZARD_UV_RESPONSE_CLUSTER_G2
0.02712 0.00001 0.00007 0.00238 0.00652 0.00000 0.00001 0.00014NETPATH_IL_5_PATHWAY_UP
0.00000 0.00000 0.00001 0.00185 0.09653 0.00000 0.00000 0.00236FOSTER_INFLAMMATORY_RESPONSE_LPS_DN
0.00078 0.00001 0.00000 0.00005 0.12968 0.00001 0.00002 0.02949MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00000 0.00000 0.00000 0.00000 0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00000 0.00799 0.00028 0.00325 0.00000 0.00142 0.00000AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00000 0.00001 0.00036 0.00000 0.00000 0.00000 0.04466GAURNIER_PSMD4_TARGETS
0.00810 0.00008 0.00097 0.00000 0.00009 0.00000 0.00000 0.00003GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00000 0.00000 0.00000 0.00000 0.00000 0.00000 0.00000 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00000 0.00001 0.00100 0.00049 0.00010 0.00126 0.00000 0.09953NCI_IL23PATHWAY
0.00000 0.00000 0.00000 0.00043 0.00000 0.00000 0.00000 0.03754ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00141 0.00000 0.02216 0.00178 0.00454 0.00002 0.00083 0.00000GESERICK_TERT_TARGETS_DN
0.00017 0.00000 0.00000 0.00000 0.00096 0.00000 0.00000 0.00530SANA_TNF_SIGNALING_UP
0.00217 0.00001 0.17968 0.17963 0.14391 0.01939 0.00010 0.10922WANG_METHYLATED_IN_BREAST_CANCER
0.06014 0.02213 0.02059 0.00000 0.00022 0.00000 0.00014 0.00008BROWNE_HCMV_INFECTION_2HR_UP
0.00080 0.00000 0.00000 0.00000 0.00029 0.00000 0.00000 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00757 0.00406 0.00002 0.00703 0.00327 0.00000 0.00001 0.00000SESTO_RESPONSE_TO_UV_C3
0.01612 0.00000 0.01564 0.00318 0.11950 0.00007 0.00002 0.00000KIM_WT1_TARGETS_UP
0.00001 0.00000 0.00000 0.00267 0.00551 0.00000 0.00000 0.00095VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.19205 0.15860 0.02184 0.02915 0.03310 0.00334 0.00047 0.01379REACTOME_P75NTR_SIGNALS_VIA_NFKB
0.00179 0.00000 0.00027 0.00051 0.03512 0.00000 0.00000 0.01687GEISS_RESPONSE_TO_DSRNA_UP
0.00000 0.00000 0.00007 0.00002 0.00003 0.00000 0.00044 0.00000UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.12191 0.14658 0.01417 0.00269 0.00025 0.00020 0.00015 0.00127KOBAYASHI_EGFR_SIGNALING_6HR_DN
0.05337 0.17372 0.16339 0.00376 0.00097 0.00487 0.00003 0.03385CORUM_TNF-ALPHA/NF-KAPPA_B_SIGNALING_COMPLEX_RPL6_RPL30_RPS13_CHUK_DDX3X_NFKB2_NFKBIB_REL_IKBKG_NFKB1_MAP3K8_RELB_GLG1_NFKBIA_RELA_TNIP2__GTF2I
0.00018 0.00001 0.00125 0.00000 0.00000 0.00047 0.00000 0.01029ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP
0.11497 0.00132 0.01014 0.10947 0.05634 0.00572 0.00009 0.03623NCI_NFKAPPABCANONICALPATHWAY
0.00000 0.00000 0.00001 0.15886 0.13442 0.00000 0.08966 0.00054HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN
0.02376 0.00001 0.00423 0.00069 0.14343 0.03451 0.00004 0.02002AMIT_EGF_RESPONSE_120_MCF10A
0.00000 0.00000 0.00054 0.00000 0.00000 0.00000 0.00000 0.00005TIAN_TNF_SIGNALING_VIA_NFKB
0.00024 0.00000 0.00001 0.00000 0.00000 0.00002 0.00000 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.00000 0.00001 0.00003 0.01781 0.00000 0.00000 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00139 0.00193 0.02848 0.00093 0.00308 0.13990 0.00010 0.00154LEE_LIVER_CANCER_HEPATOBLAST
0.08451 0.00010 0.00518 0.00002 0.00000 0.00039 0.00000 0.00013ZUCCHI_METASTASIS_DN
0.00000 0.00000 0.00001 0.00102 0.00009 0.00000 0.00003 0.00000NAGASHIMA_EGF_SIGNALING_UP
0.02502 0.00024 0.01526 0.00151 0.08362 0.00000 0.00005 0.00000PRAMOONJAGO_SOX4_TARGETS_UP
0.03435 0.00001 0.00031 0.00000 0.00000 0.00000 0.00000 0.00153HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00000 0.00000 0.01523 0.00367 0.00559 0.00004 0.00000 0.00000AMIT_EGF_RESPONSE_60_MCF10A