BICLUSTER_ID : UPREG-86
PATHOGENS /4/ : escherichia coli,yersinia enterocolitica,mycobacterium tuberculosis,helicobacter pylori
TARGETS /7/ : IL6, CCL20, PTGS2, GCH1, CCL5, CCL2, PIM1
Gene SetLeading Edge Genes
NETPATH KIT RECEPTOR PATHWAY UPIL6, JUNB, CCL5, CCL2, PIM1, IER3
NETPATH IL 1 PATHWAY UPIL6, CCL20, PTGS2, CXCL1, CCL2, CXCL2, HBEGF
NETPATH IL 4 PATHWAY DOWNCCL20, GADD45B, PTGS2, CCL2, IRF1, CXCL2, GBP2
NETPATH IL 3 PATHWAY UPCSF1, CCL2, PIM1
NCI IL23PATHWAYIL6, CXCL1, CCL2
GERY CEBP TARGETSATF3, GADD45B, CXCL1, GCH1, JUNB, PIM1, GADD45G
NETPATH IL 6 PATHWAY UPMAFF, GADD45B, CXCL1, JUNB, PIM1, IRF1, MAP3K8
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION
NOJIMA SFRP2 TARGETS UP
CHEN HOXA5 TARGETS 6HR UP
MISSIAGLIA REGULATED BY METHYLATION UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP
BIOCARTA STEM PATHWAY
NETPATH IL 9 PATHWAY UP
MAHAJAN RESPONSE TO IL1A UP
KEGG GRAFT VERSUS HOST DISEASE
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP
LINDSTEDT DENDRITIC CELL MATURATION B
SA MMP CYTOKINE CONNECTION
RASHI RESPONSE TO IONIZING RADIATION 2
LINDSTEDT DENDRITIC CELL MATURATION A
RADAEVA RESPONSE TO IFNA1 UP
WALLACE PROSTATE CANCER RACE UP
ELVIDGE HYPOXIA UP
IYENGAR RESPONSE TO ADIPOCYTE FACTORS
AMIT EGF RESPONSE 40 HELA
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN
DORN ADENOVIRUS INFECTION 12HR UP
MAHADEVAN RESPONSE TO MP470 DN
UROSEVIC RESPONSE TO IMIQUIMOD
BROWNE INTERFERON RESPONSIVE GENES
HARRIS HYPOXIA
DER IFN BETA RESPONSE UP
TSAI DNAJB4 TARGETS UP
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP
HINATA NFKB TARGETS KERATINOCYTE UP
MARKEY RB1 ACUTE LOF UP
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY
BASSO CD40 SIGNALING UP
SOUCEK MYC TARGETS
DUTTA APOPTOSIS VIA NFKB
ZERBINI RESPONSE TO SULINDAC UP
DIRMEIER LMP1 RESPONSE EARLY
DER IFN GAMMA RESPONSE UP
MAHADEVAN RESPONSE TO MP470 UP
SEMENZA HIF1 TARGETS
FERRARI RESPONSE TO FENRETINIDE UP
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY
BILD HRAS ONCOGENIC SIGNATURE
ONDER CDH1 TARGETS 3 DN
DAUER STAT3 TARGETS UP
LIANG SILENCED BY METHYLATION 2
BIOCARTA RANKL PATHWAY
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA UP
DER IFN ALPHA RESPONSE UP
MCLACHLAN DENTAL CARIES UP
MENSE HYPOXIA UP
CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX CHUK KPNA3 NFKB2 NFKBIB REL IKBKG NFKB1 NFKBIE RELB NFKBIA RELA TNIP2
CHEN HOXA5 TARGETS 9HR UP
DAZARD UV RESPONSE CLUSTER G2
MCLACHLAN DENTAL CARIES DN
AMIT SERUM RESPONSE 40 MCF10A
SEKI INFLAMMATORY RESPONSE LPS UP
GAURNIER PSMD4 TARGETS
GRAHAM CML QUIESCENT VS CML DIVIDING UP
BROWNE HCMV INFECTION 4HR UP
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP
ZHU CMV 8 HR UP
ZHOU INFLAMMATORY RESPONSE LPS UP
GESERICK TERT TARGETS DN
BIOCARTA INFLAM PATHWAY
SANA TNF SIGNALING UP
FOSTER INFLAMMATORY RESPONSE LPS UP
BROWNE HCMV INFECTION 2HR UP
XU HGF TARGETS INDUCED BY AKT1 6HR
HAHTOLA MYCOSIS FUNGOIDES CD4 UP
VERHAAK AML WITH NPM1 MUTATED UP
GEISS RESPONSE TO DSRNA UP
KEGG CYTOSOLIC DNA SENSING PATHWAY
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN
KOBAYASHI EGFR SIGNALING 6HR DN
ELVIDGE HYPOXIA BY DMOG UP
AMIT EGF RESPONSE 120 MCF10A
TIAN TNF SIGNALING VIA NFKB
ZHU CMV ALL UP
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN
LEE LIVER CANCER HEPATOBLAST
ZUCCHI METASTASIS DN
NAGASHIMA EGF SIGNALING UP
PRAMOONJAGO SOX4 TARGETS UP
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN
HINATA NFKB TARGETS FIBROBLAST UP
AMIT EGF RESPONSE 60 MCF10A
ELVIDGE HIF1A TARGETS DN
Color legend
q-value10.20.050.010.0010.0001
Color
TABLE OF Q-VALUES
yersinia enterocolitica wap bchelicobacter pylori kx1 mgepyersinia enterocolitica p60 bl6yersinia enterocolitica p60 bcmycobacterium tuberculosishelicobacter pylori kx1 npgecescherichia coliGeneSet Name
0.00004 0.00065 0.00015 0.00570 0.00019 0.09166 0.00023NETPATH_KIT_RECEPTOR_PATHWAY_UP
0.00001 0.00000 0.00000 0.00001 0.00602 0.00201 0.00000NETPATH_IL_1_PATHWAY_UP
0.00024 0.00002 0.00146 0.00040 0.00000 0.00644 0.00000NETPATH_IL_4_PATHWAY_DOWN
0.00000 0.03326 0.00000 0.00000 0.00171 0.05322 0.00000NETPATH_IL_3_PATHWAY_UP
0.00001 0.00589 0.00000 0.00000 0.00126 0.14576 0.00000NCI_IL23PATHWAY
0.00013 0.00133 0.00040 0.00510 0.00000 0.04422 0.01389GERY_CEBP_TARGETS
0.00000 0.00236 0.00000 0.00000 0.00000 0.02074 0.00000NETPATH_IL_6_PATHWAY_UP
0.00001 0.02218 0.00000 0.00000 0.00225 0.06985 0.00000KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION
0.00224 0.00032 0.00037 0.00304 0.00000 0.01127 0.00018NOJIMA_SFRP2_TARGETS_UP
0.01068 0.00126 0.01499 0.02172 0.00079 0.08749 0.13852CHEN_HOXA5_TARGETS_6HR_UP
0.00107 0.00725 0.00038 0.00145 0.00000 0.00255 0.00000MISSIAGLIA_REGULATED_BY_METHYLATION_UP
0.00000 0.00008 0.00000 0.00000 0.00000 0.09695 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP
0.00000 0.03509 0.00021 0.00000 0.00002 0.18497 0.00000GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.04118 0.02542 0.03650 0.03900 0.14979 0.01484 0.00008BIOCARTA_STEM_PATHWAY
0.00001 0.00013 0.00016 0.00009 0.08229 0.00667 0.00028NETPATH_IL_9_PATHWAY_UP
0.00000 0.00517 0.00010 0.00009 0.00132 0.00083 0.00000MAHAJAN_RESPONSE_TO_IL1A_UP
0.00024 0.02385 0.00069 0.00055 0.02321 0.07771 0.00002KEGG_GRAFT_VERSUS_HOST_DISEASE
0.00000 0.02414 0.00011 0.00000 0.00000 0.00000 0.00000ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP
0.00004 0.00000 0.04591 0.00237 0.00000 0.00011 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_B
0.00860 0.01005 0.01474 0.00023 0.00814 0.13965 0.00133SA_MMP_CYTOKINE_CONNECTION
0.00001 0.00000 0.00297 0.00008 0.00000 0.10813 0.00000RASHI_RESPONSE_TO_IONIZING_RADIATION_2
0.00000 0.00015 0.00029 0.00000 0.00000 0.00003 0.00000LINDSTEDT_DENDRITIC_CELL_MATURATION_A
0.00379 0.08041 0.00709 0.00008 0.00000 0.00052 0.00000RADAEVA_RESPONSE_TO_IFNA1_UP
0.00000 0.17667 0.00029 0.00000 0.00000 0.03695 0.00004WALLACE_PROSTATE_CANCER_RACE_UP
0.00006 0.00083 0.00031 0.00036 0.00052 0.11617 0.01124ELVIDGE_HYPOXIA_UP
0.06007 0.00293 0.00563 0.00492 0.00217 0.00098 0.00026IYENGAR_RESPONSE_TO_ADIPOCYTE_FACTORS
0.00018 0.00125 0.00021 0.00031 0.00000 0.12195 0.00000AMIT_EGF_RESPONSE_40_HELA
0.01934 0.08369 0.03385 0.02619 0.01382 0.09623 0.01179GUTIERREZ_WALDENSTROEMS_MACROGLOBULINEMIA_1_DN
0.01175 0.00382 0.00175 0.00041 0.00008 0.05966 0.04767DORN_ADENOVIRUS_INFECTION_12HR_UP
0.00006 0.00340 0.00072 0.00009 0.00000 0.09518 0.00317MAHADEVAN_RESPONSE_TO_MP470_DN
0.00537 0.19498 0.00167 0.00028 0.00000 0.00000 0.00000UROSEVIC_RESPONSE_TO_IMIQUIMOD
0.00000 0.07388 0.00006 0.00000 0.00000 0.00000 0.00000BROWNE_INTERFERON_RESPONSIVE_GENES
0.00004 0.00027 0.00029 0.00029 0.00067 0.08612 0.00034HARRIS_HYPOXIA
0.00563 0.04581 0.04762 0.00056 0.00000 0.00085 0.00000DER_IFN_BETA_RESPONSE_UP
0.16954 0.02725 0.06839 0.02491 0.00004 0.08948 0.01475TSAI_DNAJB4_TARGETS_UP
0.00012 0.00015 0.02538 0.00299 0.00000 0.02451 0.00002DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP
0.00000 0.00002 0.00000 0.00000 0.00000 0.00256 0.00000HINATA_NFKB_TARGETS_KERATINOCYTE_UP
0.00001 0.07713 0.01647 0.00004 0.00000 0.00008 0.00000MARKEY_RB1_ACUTE_LOF_UP
0.00000 0.00005 0.00058 0.00008 0.00060 0.06948 0.00000KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00077 0.00018 0.00003 0.00000 0.12757 0.00000BASSO_CD40_SIGNALING_UP
0.00001 0.00011 0.00018 0.00008 0.02521 0.00009 0.00037SOUCEK_MYC_TARGETS
0.00003 0.00000 0.00201 0.00013 0.00002 0.05736 0.00000DUTTA_APOPTOSIS_VIA_NFKB
0.16203 0.00318 0.05840 0.12784 0.04554 0.06538 0.02814ZERBINI_RESPONSE_TO_SULINDAC_UP
0.00000 0.00157 0.00018 0.00000 0.00000 0.06932 0.00000DIRMEIER_LMP1_RESPONSE_EARLY
0.00850 0.03795 0.14426 0.00263 0.00000 0.00454 0.00000DER_IFN_GAMMA_RESPONSE_UP
0.00006 0.00002 0.00018 0.00000 0.00004 0.00000 0.00000MAHADEVAN_RESPONSE_TO_MP470_UP
0.04194 0.00102 0.00609 0.02874 0.04672 0.01227 0.14703SEMENZA_HIF1_TARGETS
0.00007 0.00008 0.01472 0.00050 0.00018 0.11271 0.00016FERRARI_RESPONSE_TO_FENRETINIDE_UP
0.00000 0.00018 0.00012 0.00000 0.00176 0.00000 0.00000REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES
0.03958 0.00095 0.06399 0.04758 0.00002 0.14476 0.00000KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00029 0.00000 0.00000 0.00000 0.16783 0.00000BILD_HRAS_ONCOGENIC_SIGNATURE
0.01083 0.00085 0.00026 0.00099 0.10086 0.06938 0.00000ONDER_CDH1_TARGETS_3_DN
0.06147 0.00067 0.06189 0.02597 0.00000 0.01934 0.00003DAUER_STAT3_TARGETS_UP
0.00007 0.00031 0.00000 0.00000 0.00000 0.00000 0.00000LIANG_SILENCED_BY_METHYLATION_2
0.02104 0.02627 0.07528 0.01255 0.03099 0.04517 0.05932BIOCARTA_RANKL_PATHWAY
0.10223 0.02466 0.02528 0.08621 0.00000 0.10968 0.04537NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP
0.00012 0.01988 0.10917 0.00659 0.02002 0.14559 0.00438NIELSEN_MALIGNAT_FIBROUS_HISTIOCYTOMA_UP
0.01898 0.14451 0.14030 0.00389 0.00000 0.00025 0.00000DER_IFN_ALPHA_RESPONSE_UP
0.00000 0.00018 0.00050 0.00008 0.00000 0.02102 0.00000MCLACHLAN_DENTAL_CARIES_UP
0.00167 0.00855 0.17416 0.06772 0.00000 0.00732 0.09188MENSE_HYPOXIA_UP
0.05725 0.00204 0.07034 0.02325 0.00136 0.10289 0.00012CORUM_TNF-ALPHA/NF-KAPPA_B_SIGNALING_COMPLEX_CHUK_KPNA3_NFKB2_NFKBIB_REL_IKBKG__NFKB1_NFKBIE_RELB__NFKBIA_RELA_TNIP2
0.00001 0.00000 0.00807 0.00074 0.00006 0.00899 0.00050CHEN_HOXA5_TARGETS_9HR_UP
0.00772 0.00079 0.01250 0.01385 0.01541 0.15355 0.00004DAZARD_UV_RESPONSE_CLUSTER_G2
0.00001 0.00030 0.00065 0.00014 0.00001 0.06509 0.00002MCLACHLAN_DENTAL_CARIES_DN
0.00000 0.00874 0.00000 0.00004 0.00000 0.13910 0.00142AMIT_SERUM_RESPONSE_40_MCF10A
0.00000 0.00000 0.00000 0.00000 0.00000 0.00000 0.00000SEKI_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00002 0.00000 0.00000 0.00000 0.00000 0.00000GAURNIER_PSMD4_TARGETS
0.00008 0.00937 0.00398 0.00030 0.00000 0.00796 0.00000GRAHAM_CML_QUIESCENT_VS_CML_DIVIDING_UP
0.00028 0.00261 0.00019 0.00000 0.00024 0.06493 0.00000BROWNE_HCMV_INFECTION_4HR_UP
0.00000 0.00000 0.00000 0.00000 0.00000 0.00002 0.00000ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP
0.00004 0.01261 0.00061 0.00000 0.00000 0.00000 0.00000ZHU_CMV_8_HR_UP
0.00000 0.00307 0.00000 0.00000 0.00000 0.00001 0.00000ZHOU_INFLAMMATORY_RESPONSE_LPS_UP
0.00000 0.00257 0.00000 0.00004 0.00002 0.01048 0.00083GESERICK_TERT_TARGETS_DN
0.00006 0.05381 0.00000 0.00004 0.05068 0.04107 0.00000BIOCARTA_INFLAM_PATHWAY
0.00000 0.00000 0.00022 0.00000 0.00000 0.00000 0.00000SANA_TNF_SIGNALING_UP
0.00000 0.00587 0.00004 0.00000 0.00000 0.03879 0.00011FOSTER_INFLAMMATORY_RESPONSE_LPS_UP
0.02213 0.00034 0.00222 0.00673 0.00000 0.02678 0.00014BROWNE_HCMV_INFECTION_2HR_UP
0.00321 0.04723 0.02501 0.02068 0.00001 0.01849 0.00014XU_HGF_TARGETS_INDUCED_BY_AKT1_6HR
0.00000 0.00215 0.00030 0.00006 0.00000 0.06147 0.00000HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP
0.00000 0.00063 0.00000 0.00000 0.00000 0.06454 0.00000VERHAAK_AML_WITH_NPM1_MUTATED_UP
0.00000 0.00000 0.00109 0.00000 0.00000 0.00002 0.00000GEISS_RESPONSE_TO_DSRNA_UP
0.01094 0.03185 0.00200 0.00805 0.00059 0.00515 0.00000KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY
0.00000 0.00000 0.00000 0.00000 0.00000 0.00603 0.00044UZONYI_RESPONSE_TO_LEUKOTRIENE_AND_THROMBIN
0.14658 0.00064 0.04783 0.11776 0.00020 0.10830 0.00015KOBAYASHI_EGFR_SIGNALING_6HR_DN
0.00045 0.00023 0.00028 0.00017 0.00043 0.06336 0.01098ELVIDGE_HYPOXIA_BY_DMOG_UP
0.00001 0.02386 0.00086 0.00028 0.03451 0.19126 0.00004AMIT_EGF_RESPONSE_120_MCF10A
0.00000 0.00000 0.00016 0.00000 0.00000 0.00000 0.00000TIAN_TNF_SIGNALING_VIA_NFKB
0.00018 0.01293 0.03630 0.00004 0.00000 0.00201 0.00000ZHU_CMV_ALL_UP
0.00177 0.01726 0.01680 0.00219 0.00000 0.14588 0.00000KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY
0.00000 0.00000 0.00037 0.00000 0.00002 0.00039 0.00000GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP
0.00000 0.00010 0.00000 0.00000 0.00000 0.10013 0.00000OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN
0.00193 0.07700 0.00058 0.00168 0.13990 0.18870 0.00010LEE_LIVER_CANCER_HEPATOBLAST
0.00010 0.00723 0.04370 0.05022 0.00039 0.02425 0.00000ZUCCHI_METASTASIS_DN
0.00000 0.00000 0.00000 0.00000 0.00000 0.01564 0.00003NAGASHIMA_EGF_SIGNALING_UP
0.00024 0.00000 0.02844 0.00119 0.00000 0.00004 0.00005PRAMOONJAGO_SOX4_TARGETS_UP
0.00000 0.00002 0.00000 0.00000 0.00000 0.15432 0.02690PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN
0.00001 0.00000 0.00034 0.00008 0.00000 0.05134 0.00000HINATA_NFKB_TARGETS_FIBROBLAST_UP
0.00000 0.00002 0.00000 0.00000 0.00004 0.04711 0.00000AMIT_EGF_RESPONSE_60_MCF10A
0.06497 0.04742 0.10495 0.14639 0.04594 0.07454 0.11828ELVIDGE_HIF1A_TARGETS_DN