CD38→Cyclic ADP-Ribose→Cyclic ADP-Ribose→poly-ADP-ribose

• 10233418(CD38): Human myeloma cells express the CD38 ligand CD31.

  All 68 patients studied were CD38 +.

• 8630392(Cyclic ADP-Ribose): Expression of cyclic ADP-ribose-synthetizing CD38 molecule on human platelet membrane.

  It has been recently shown that CD38 displays three enzymatic activities : hydrolysis of NAD + to ADP-ribose , synthesis of cyclic ADP-ribose from NAD + , and hydrolysis of cyclic ADP-ribose to ADP-ribose.

• 10437804(Cyclic ADP-Ribose): Hydrolysis of NADP+ by platelet CD38 in the absence of synthesis and degradation of cyclic ADP-ribose 2'-phosphate.

  CD38 is a multifunctional cell surface ectoenzyme that catalyzes both the synthesis of cyclic ADP-ribose from NAD + and its hydrolysis to ADP-ribose.

• 6322868(poly-ADP-ribose): [ADP-ribosylation of histones of the chicken liver nucleus at different rates of glycohydrolase hydrolysis of NAD]

  With a rise in the NAD-glycohydrolase activity after treatment of nuclei with Triton X-100 the synthesis of poly (ADP-ribose) via the poly (ADPR) polymerase reaction is augmented , as a result of which the rate of (Ado-U-14C) NAD incorporation into total histones is increased.