MCP-2→Nos2 protein, rat→Hydrogen Peroxide→poly-ADP-ribose

• 10644541(MCP-2): Metoclopramide: a novel adjunct for improving cardiac and hepatocellular functions after trauma-hemorrhage.

  The results indicate that treatment with MCP after trauma-hemorrhage and resuscitation significantly improved the depressed cardiac output and hepatocellular function.

• 10485596(Nos2 protein, rat): Inhibition of poly(ADP-ribose) synthetase improves vascular contractile responses following trauma-hemorrhage and resuscitation.

  In this study , we determined if inhibition of poly (ADP-ribose) synthetase (PARS) activity prevented the development of vascular hyporeactivity in rats following trauma-hemorrhage and resuscitation.

• 7643121(Hydrogen Peroxide): Poly(ADP-ribose) synthetase activation: an early indicator of neurotoxic DNA damage.

  DNA damage activates a nuclear enzyme poly (ADP-ribose) synthetase (PARS) that facilitates DNA repair by adding multiple ADP-ribose groups to nuclear proteins such as histones and PARS itself.

• 3158622(poly-ADP-ribose): Influence of poly(ADP-ribose) synthesis inhibitors on the repair of sublethal and potentially lethal damage in gamma-irradiated mammalian cells.

  The poly (ADP-ribose) inhibitors do not modify the repair of sublethal damage , but totally suppress the repair of potentially lethal damage , as shown by the survival of CHO cells and of a human osteosarcoma cell line.