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10880243(IL-1+alpha): TNF-alpha and IL-1alpha induce apoptosis in subconfluent rat mesangial cells. Evidence for the involvement of hydrogen peroxide and lipid peroxidation as second messengers.
TNF-alpha as well as IL-1alpha stimulated the production of reactive oxygen species (ROS) and induced lipid peroxidation.
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7739519(Tumor Necrosis Factor-alpha): Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA.
These results suggest that TNF-alpha induces apoptosis in neuronal cells by a pathway that involves formation of reactive oxygen intermediates and which can be blocked by specific genetic interventions.
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1280112(Tumor Necrosis Factor-alpha): Induction of nitric oxide synthase in L929 cells by tumour-necrosis factor alpha is prevented by inhibitors of poly(ADP-ribose) polymerase.
Induction of NO synthase by TNF-alpha was prevented by inhibitors of poly (ADP-ribose) polymerase , namely nicotinamide , 3-methoxybenzamide and 3-aminobenzamide.
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9521710(poly-ADP-ribose): Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling.
Inhibitors of poly (ADP-ribose) polymerase (PARP , EC 2.4.2.30) are of clinical interest because they have potential for improving radiation therapy and chemotherapy of cancer.