CXCL1→Poly(ADP-ribose) Polymerases→Nucleoside Diphosphate Sugars→poly-ADP-ribose

• 11483765(CXCL1): Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy.

  We have demonstrated previously that GRO-alpha then stimulates HIV-1 replication in both T lymphocytes and macrophages.

• 15280503(Poly(ADP-ribose) Polymerases): RNA interference directed against Poly(ADP-Ribose) polymerase 1 efficiently suppresses human immunodeficiency virus type 1 replication in human cells.

  These results indicate that PARP-1 is required for efficient HIV-1 replication in human cells.

• 2512056(Nucleoside Diphosphate Sugars): DNA replication and poly(ADP-ribosyl)ation of chromatin.

  The role of poly (ADP-ribosyl) ation in chromatin replication and the activity of poly (ADP-ribose) synthetase in the newly synthesized and old chromatin was studied.

• 7488045(poly-ADP-ribose): Reduction of mono(ADP-ribosyl)ation of histones in rat testis by gonadotropin-testosterone system.

  When the nuclear fraction was incubated with (32P) NAD in the presence of nicotinamide , an inhibitor of poly (ADP-ribose) synthetase , some proteins with a molecular mass of 14.4 -21.5 kDa were ADP-ribosylated.