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11853403(CD38): Resting CD4(+) T cells with CD38(+)CD62L(+) produce interleukin-4 which contributes to enhanced replication of T-tropic human immunodeficiency virus type 1.
A significant increase in the CD38 (+) population among T lymphocytes has been observed in human immunodeficiency virus type 1 (HIV-1) - infected carriers.
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15280503(Poly(ADP-ribose) Polymerases): RNA interference directed against Poly(ADP-Ribose) polymerase 1 efficiently suppresses human immunodeficiency virus type 1 replication in human cells.
Established siRNA against PARP-1 significantly suppressed human immunodeficiency virus type 1 (HIV-1) replication , as well as the activation of the integrated HIV-1 long terminal repeat promoter.
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18579376(Poly(ADP-ribose) Polymerases): Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase.
We have previously described poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors based on a substituted benzyl-phthalazinone scaffold.
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15293985(poly-ADP-ribose): Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.
A novel class of quinazolinone derivatives as potent poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors has been discovered.