stanniocalcin→Glucagon→Poly(ADP-ribose) Polymerases→poly-ADP-ribose

• 11861508(stanniocalcin): Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice.

  The reproductive potential of female transgenic mice was also compromised , as evidenced by significantly smaller litter sizes , but transgenic male fertility was unchanged even though the transgene was most highly expressed in testes.

• 10727441(Glucagon): Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.

  We generated transgenic mice (C57BL6/SJL) expressing IGF-II in beta cells under control of the rat Insulin I promoter in order to study the role of islet hyperplasia and hyperinsulinemia in the development of type 2 diabetes.

• 10077636(Poly(ADP-ribose) Polymerases): Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes.

  Thus , PARP activation may participate in the pathophysiology of type I diabetes , for which PARP inhibitors might afford therapeutic benefit.

• 11420111(poly-ADP-ribose): Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone.

  beta-Lapachone inhibited PARP , apparently by direct interaction with the enzyme.