IL-1 alpha→Carrageenan→poly-ADP-ribose

• 12182845(IL-1+alpha): Increase in serum level of interleukin-1 alpha mediates morphine anti-inflammatory effect in carrageenan-induced paw oedema in mice.

  In the present studies we examined the effects of an intra-peritoneal injection of morphine (7 mg/kg) on carrageenan-induced paw oedema in mice.

• 16501055(Carrageenan): The role of the peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in the regulation of acute inflammation.

  We report here that when compared with PPAR-alpha wild-type mice , PPAR-alpha knockout mice (PPAR-alphaKO) mice experienced a higher rate of the extent and severity when subjected to carrageenan injection in the paw edema model or to carrageenan administration in the pleurisy model.

• 16317386(poly-ADP-ribose): ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR alpha IN THE DEVELOPMENT OF BLEOMYCIN-INDUCED LUNG INJURY.

  An increase of immunoreactivity to poly-ADP-ribose , TNF-alpha , and IL-1 beta , as well as a significant loss of body weight and mortality was observed in the lung of bleomycin-treated PPAR-alpha WT mice.