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12243084(nicotinamide): [Effect of nicotinamide adenine dinucleotide on the serotoninergic mediator system in the rat brain during 3-acetylpyridine administration]
The effect of administration of 3-acetylpyridine (antivitamin B3) , on rat brain serotoninergic and NAD receptor systems was investigated.
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13878(NAD): [Effect of hypoxia on the concentration of nicotinamide coenzymes in the tissues of newborn rats]
There was a marked reduction of NAD content , an accumulation of NAD-H and a more than two-fold fall of the NAD/NAD-H ratio particularly marked in the brain and heart.
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2156280(Nucleotidyltransferases): [The effect of the x-ray irradiation of rats on the NAD-pyrophosphorylase and poly(ADP-ribose)polymerase activities of brain nuclei and on the NAD content in nerve tissue]
Stimulation of poly (ADP-ribose) polymerase activity of nuclei was a function of radiation dose and correlated with the decrease in the NAD content of nervous tissue.
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2942307(Niacinamide): Influence of inhibitors of poly(ADP-ribose)polymerase activity on X-ray and ultraviolet light induced killing and mutation in Chinese hamster V79 cells.
Inhibitors of poly (ADP-ribose) polymerase suppressed PLDR and also increased the yield of mutants.
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6315616(poly-ADP-ribose): Inhibitors of poly(ADP-ribose) synthetase enhance the cytotoxicity of 42 degrees C and 45 degrees C hyperthermia in cultured Chinese hamster cells.
The results suggest a possible role for poly (ADP-ribose) synthetase in the survival response of V79 cells to hyperthermia.