IL-13→Intercellular Adhesion Molecule-1→Nucleoside Diphosphate Sugars→poly-ADP-ribose

• 12537753(IL-13): Cytokine and adhesion molecule expression in primary human endothelial cells stimulated with fever-range hyperthermia.

  Previous in vivo studies have shown that febrile temperatures dynamically stimulate adhesion in differentiated high endothelial venules (HEV) , which are portals for lymphocyte extravasation.

• 15304054(Intercellular Adhesion Molecule-1): Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase.

  It has been previously reported that endothelial cells exposed to constant high concentrations of glucose upregulate the expression of adhesion molecules.

• 3932085(Nucleoside Diphosphate Sugars): Cellular regulation of poly(ADP) ribosylation of proteins. I. Comparison of hepatocytes, cultured cells and liver nuclei and the influence of varying concentrations of NAD.

  At 0.1 microM NAD as substrate pmol quantities of monomeric ADP-ribose adducts per mg DNA were formed and the main acceptors were sharply discernable on the basis of molecular mass as histones , high mobility non-histone proteins , two protein groups of a mass of 66 and 44 kD respectively , and the poly (ADP-ribose) polymerase enzyme protein of 119 kD mass..

• 165508(poly-ADP-ribose): Macromolecular enzymatic product of NAD+ in liver mitochondria.

  Identification of these products and reversibility of the reaction show that the ADP-ribose moiety of NAD + is the molecular species that is transferred to the acceptor protein.