nicotinamide→Transcription Factor AP-1→Niacinamide→Isoquinolines→poly-ADP-ribose

• 12868016(nicotinamide): Functional rescue of N-methyl-N-nitrosourea-induced retinopathy by nicotinamide in Sprague-Dawley rats.

  CONCLUSIONS : NAM can protect photoreceptor cells from MNU-induced retinopathy both structurally and functionally.

• 16168987(Transcription Factor AP-1): Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADP-ribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition.

  Therefore , NAM blocked MNU-induced photoreceptor cell apoptosis by inhibiting both PARP activity and the JNK/AP -1 signalling pathway.

• 9705078(Niacinamide): Nicotinamide-induced apoptosis in insulin producing cells is associated with cleavage of poly(ADP-ribose) polymerase.

  We have presently determined the effect of inhibition of the DNA repair enzyme poly (ADP-ribose) polymerase (PARP) on the occurrence of apoptosis in insulin-producing cells.

• 9578465(Isoquinolines): Repression of phosphoenolpyruvate carboxykinase gene activity by insulin is blocked by 3-aminobenzamide but not by PD128763, a selective inhibitor of poly(ADP-ribose) polymerase.

  Analysis of poly (ADP-ribose) polymerase activity and poly (ADP-ribosyl) ation confirmed that there were no significant changes in response to insulin , while microsomal mono (ADP-ribosyl) transferase activity was elevated approximately fourfold.

• 8835300(poly-ADP-ribose): Inhibition of the induction of collagenase by interleukin-1 beta in cultured rabbit synovial fibroblasts after treatment with the poly(ADP-ribose)-polymerase inhibitor 3-aminobenzamide.

  3-Aminobenzamide is an inhibitor of poly - (ADP-ribosyl) ation.