IL-13→Antibodies, Monoclonal→Tumor Necrosis Factor-alpha→poly-ADP-ribose

• 12897201(IL-13): IL-13 and adenosine: partners in a molecular dance?

  Both adenosine and IL-13 play critical roles in contributing pathways.

• 15566951(Antibodies, Monoclonal): Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling.

  A substantial amount of evidence suggests that IL-13 plays a critical role in the pathogenesis of asthma.

• 19718408(Tumor Necrosis Factor-alpha): The soluble tumor necrosis factor-alpha receptor suppresses airway inflammation in a murine model of acute asthma.

  TNF-alpha blocking strategies are now being tried in asthma patients.

• 9334851(poly-ADP-ribose): Inhibitory effect of nicotinamide on in vitro and in vivo production of tumor necrosis factor-alpha.

  In addition to these , we have found an inhibitory effect of nicotinamide on production of tumor necrosis factor-alpha (TNF-alpha) in vitro and in vivo.