IL-13→Chemokines→1-Naphthylamine→poly-ADP-ribose

• 12919086(IL-13): Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold ischemia/reperfusion injury are heme oxygenase-1 dependent.

  Liver injury caused by ischemia/reperfusion (I/R) insult represents the major problem following orthotopic liver transplantation (OLT).

• 16953120(Chemokines): SP600125, a selective JNK inhibitor, aggravates hepatic ischemia-reperfusion injury.

  c-Jun N-terminal kinase (JNK) is activated during hepatic reperfusion , and JNK inhibitors are known to protect other major organs from ischemia-reperfusion (I/R) injury.

• 12686864(1-Naphthylamine): The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.

  PURPOSE : Poly (adenosine diphosphate (ADP) - ribose) polymerase inhibitors have been used successfully to decrease ischemia-reperfusion injury in several organ systems.

• 3000421(poly-ADP-ribose): Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).

  Poly (adenosine 5 ' - diphosphate ribose) (poly (ADP-ribose)) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide , especially in 0.5 M NaCl and at an alkaline pH..