IL-13→Cyclic ADP-Ribose→Histones→poly-ADP-ribose

• 14734772(IL-13): The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling.

  These studies demonstrate that IL-13 is a potent stimulator of C10/CCL6 and highlight the importance of C10/CCL6 and signaling via CCR1 in the pathogenesis of the IL-13-induced pulmonary phenotype.

• 14764428(Cyclic ADP-Ribose): Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway.

  CD38/cyclic adenosine diphosphate ribose (cADPR) signaling plays an important role in the regulation of intracellular calcium responses to agonists in a variety of cells , including airway smooth muscle (ASM) cells.

• 217534(Histones): Effect of 1-methyl-1-nitrosourea on poly(adenosine diphosphate-ribose) polymerase activity at the nucleosomal level.

  The stimulation of poly (adenosine diphosphate ribose) (poly (ADP-ribose)) polymerase activity at the nuclear level after damage of HeLa cells by 1-methyl-1-nitrosourea has been previously reported.

• 3000421(poly-ADP-ribose): Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).

  Poly (adenosine 5 ' - diphosphate ribose) (poly (ADP-ribose)) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide , especially in 0.5 M NaCl and at an alkaline pH..