serpinB2→Interleukin-1→Tumor Necrosis Factor-alpha→poly-ADP-ribose

• 15075337(serpinB2): Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes.

  It has become apparent that this pathway interacts with a variety of signaling pathways that are believed to be involved in mediating TCDD/AhR biological effects.

• 15019843(Interleukin-1): MAPK signaling pathways modulate IL-1beta expression in human keratinocytes.

  The signaling pathways that modulate IL-1beta expression in human keratinocytes have not been well defined.

• 14669994(Tumor Necrosis Factor-alpha): Modulation of the activation of extracellular signal-regulated kinase (ERK) and the production of inflammatory mediators by ADP-ribosylation inhibitors.

  Here we have investigated the mechanism by which ADP-ribosylation inhibitors block signaling pathways induced in macrophages.

• 6309564(poly-ADP-ribose): ADP-ribosylation regulates the phosphorylation of histones by the catalytic subunit of cyclic AMP-dependent protein kinase.

  Therefore , the possibility that ADP-ribosylation may regulate the phosphorylation of histones phosphorylation in nuclei warrants further investigation.