CXCL1→Interleukin-6→Poly(ADP-ribose) Polymerases→poly-ADP-ribose

• 15843053(CXCL1): Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population.

  Inflammation is profoundly involved in the development of Alzheimer 's disease (AD) and other neurodegenerative diseases.

• 19957198(Interleukin-6): Association between interleukin-6 gene promoter -572C/G polymorphism and the risk of sporadic Alzheimer's disease.

  Inflammation is a key component of Alzheimer 's disease (AD) , and we have examined the effect of two polymorphisms (-174 G/C and -572 C/G) in the promoter of the inflammatory cytokine interleukin-6 (IL-6) gene on risk of AD in 318 AD patients.

• 17290104(Poly(ADP-ribose) Polymerases): Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk.

  Poly (ADP-ribose) polymerase 1 (PARP-1) is a nuclear protein recently implicated in the initial inflammatory response by modulating expression of inflammation-related genes , like interleukin 1 (IL-1).

• 11040421(poly-ADP-ribose): Comparison of the ADP-ribosylating thermozyme from Sulfolobus solfataricus and the mesophilic poly(ADP-ribose) polymerases.

  With respect to the charge , the archaeal enzyme behaved differently from the eukaryotic thermolabile poly (ADP-ribose) polymerase , described as a basic protein (pI = 9.5).