CXCL1→Poly(ADP-ribose) Polymerases→Transcription Factors→poly-ADP-ribose

• 15843053(CXCL1): Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population.

  Inflammation is profoundly involved in the development of Alzheimer 's disease (AD) and other neurodegenerative diseases.

• 17290104(Poly(ADP-ribose) Polymerases): Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk.

  Excessive release of proinflammatory cytokines by activated microglia surrounding senile plaques might contribute to the neurodegeneration associated with Alzheimer 's disease (AD).

• 11854472(Transcription Factors): Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia.

  In the present study , we demonstrate in PARP-1 - / - glial cells a loss of several stress-activated transcription factors as well as decreased expression of genes for cytokines and cellular adhesion molecules.

• 18619441(poly-ADP-ribose): Dependence of trans-ADP-ribosylation and nuclear glycolysis on the Arg 34-ATP complex of Zn2+ finger I of poly-ADP-ribose polymerase-1.

  Cellular PARP-1 activity was recovered when the centrifugal sediment was recombined with the supernatant fraction containing cellular ADP-ribose oligomer acceptor proteins.