CXCL1→Poly(ADP-ribose) Polymerases→Poly(ADP-ribose) Polymerases→poly-ADP-ribose

• 15843053(CXCL1): Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population.

  Chemokine , CXC motif , ligand 1 (CXCL1 ; or GRO1) is an inflammatory cytokine and appears to be implicated in the pathogenesis of AD.

• 17290104(Poly(ADP-ribose) Polymerases): Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk.

  Poly (ADP-ribose) polymerase 1 (PARP-1) is a nuclear protein recently implicated in the initial inflammatory response by modulating expression of inflammation-related genes , like interleukin 1 (IL-1).

• 12650200(Poly(ADP-ribose) Polymerases): Effect of simulated microgravity conditions on poly(ADP-ribose) polymerase activity in primary cultures of adult rat hepatocytes.

  Moreover , PARP-1 can control its protein and DNA interactions by catalyzing its automodification with poly (ADP-ribose) molecules that can include up to 200 ADP-ribose residues and several branching points ; by these polymers , PARP-1 may nocovalently interact with other proteins and alter their functions.

• 228176(poly-ADP-ribose): Characterisation of poly(ADP-Rib) polymerase activity in nuclei from the slime mould Dictyostelium discoideum.

  The optimum incubation conditions for the poly (ADP-Rib) polymerase were determined.