CXCL1→Poly(ADP-ribose) Polymerases→Histones→poly-ADP-ribose

• 15843053(CXCL1): Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population.

  Chemokine , CXC motif , ligand 1 (CXCL1 ; or GRO1) is an inflammatory cytokine and appears to be implicated in the pathogenesis of AD.

• 17290104(Poly(ADP-ribose) Polymerases): Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk.

  Poly (ADP-ribose) polymerase 1 (PARP-1) is a nuclear protein recently implicated in the initial inflammatory response by modulating expression of inflammation-related genes , like interleukin 1 (IL-1).

• 217534(Histones): Effect of 1-methyl-1-nitrosourea on poly(adenosine diphosphate-ribose) polymerase activity at the nucleosomal level.

  The stimulation of poly (adenosine diphosphate ribose) (poly (ADP-ribose)) polymerase activity at the nuclear level after damage of HeLa cells by 1-methyl-1-nitrosourea has been previously reported.

• 3000421(poly-ADP-ribose): Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).

  Poly (adenosine 5 ' - diphosphate ribose) (poly (ADP-ribose)) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide , especially in 0.5 M NaCl and at an alkaline pH..