MMP12→Poly(ADP-ribose) Polymerases→Dimethyl Sulfoxide→poly-ADP-ribose

• 15987457(MMP12): Genetic polymorphisms in the matrix metalloproteinase 12 gene (MMP12) and breast cancer risk and survival: the Shanghai Breast Cancer Study.

  CONCLUSION : This result suggests that MMP12 A1082G polymorphism may be related to prognosis in breast cancer patients.

• 9295059(Poly(ADP-ribose) Polymerases): Poly(ADP-ribose) polymerase in human breast cancer: a case-control analysis.

  The importance of a genetic polymorphism (A/B allele) of poly (ADP-ribose) polymerase (PARP) pseudogene on chromosome 13q34-qter , and PARP enzyme activities in the development of human breast cancer were evaluated in a cancer case-control study.

• 9381409(Dimethyl Sulfoxide): Effect of a poly(ADP-ribose) polymerase inhibitor on DNA breakage and cytotoxicity induced by hydrogen peroxide and gamma-radiation.

  The activity of poly (ADP-ribose) polymerase (PARP) is activated upon recognition of DNA strand breaks by its DNA-binding domain and the stimulation of this nuclear enzyme seems to be an early response of cells exposed to a variety of different DNA-damaging agents.

• 2940104(poly-ADP-ribose): DNA strand breaks, NAD metabolism, and programmed cell death.

  The balanced DNA excision-repair process is accompanied by a proportional consumption of NAD for poly (ADP-ribose) synthesis.