IL-1 alpha→Poly(ADP-ribose) Polymerases→Antibodies, Antinuclear→poly-ADP-ribose

• 16101131(IL-1+alpha): Increased expression of interleukin-1alpha and cyclooxygenase-2 in human gastric cancer: a possible role in tumor progression.

  BACKGROUND : Cyclooxygenase (COX) -2 mRNA and protein expression have been found to be frequently up-regulated in human gastric cancers and cell lines.

• 15952054(Poly(ADP-ribose) Polymerases): Gene 33 inhibits apoptosis of breast cancer cells and increases poly(ADP-ribose) polymerase expression.

  Exogenous expression of Gene 33 in MCF-7 cells did not affect cell cycle distribution , but inhibited apoptosis and specifically increased the level of Poly (ADP-ribose) Polymerase (PARP-1) protein.

• 16541210(Antibodies, Antinuclear): [The apoptosis marker enzyme poly-(ADP-ribose) polymerase (PARP) in systemic lupus erythematosus]

  The enzyme poly - (ADP-ribose) polymerase (PARP) is localized within the cell nucleus and catalyzes DNA-repair.

• 11420111(poly-ADP-ribose): Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone.

  Crithidia fasciculata poly (ADP-ribose) polymerase (PARP) has been isolated and partially purified.