nicotinamide→Tumor Necrosis Factor-alpha→NF-kappa B→poly-ADP-ribose

• 16701870(nicotinamide): Pre-B-cell colony-enhancing factor (PBEF/Visfatin) gene expression is modulated by NF-kappaB and AP-1 in human amniotic epithelial cells.

  The aim of this study was to determine the involvement of the transcription factors NF-kappaB and AP-1 in the response of PBEF to an inflammatory stimulus and compare it with IL-8.

• 9830008(Tumor Necrosis Factor-alpha): H2O2 and tumor necrosis factor-alpha induce differential binding of the redox-responsive transcription factors AP-1 and NF-kappaB to the interleukin-8 promoter in endothelial and epithelial cells.

  In this study , we examine the role of the redox-responsive transcription factors AP-1 and nuclear factor-kappaB (NF-kappaB) in the differential expression of IL-8.

• 10494847(NF-kappa B): A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation.

  Finally , we show that both NF-kappaB and PARP formed a stable immunoprecipitable nuclear complex.

• 11420111(poly-ADP-ribose): Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone.

  beta-Lapachone inhibited PARP , apparently by direct interaction with the enzyme.