IGF-1→Phosphotyrosine→tyrphostin AG 1024→poly-ADP-ribose

• 17187980(IGF-1): Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase.

  This report discusses the SAR of 4 - (2-hydroxy-2-phenylethylamino) - substituted pyridones with improved IGF-1R potency.

• 14729630(Phosphotyrosine): Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.

  In this study we investigated the effects of cyclolignans and related molecules on IGF-1R activity.

• 17846171(tyrphostin AG 1024): A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop.

  Here we report a novel function for IGF-1R in p53-dependent apoptotic response.

• 11672522(poly-ADP-ribose): Negative control of p53 by Sir2alpha promotes cell survival under stress.

  These results have significant implications regarding an important role for Sir2alpha in modulating the sensitivity of cells in p53-dependent apoptotic response and the possible effect in cancer therapy.