IL-1 beta→Interleukin-1→Prolactin→poly-ADP-ribose

• 17196563(IL-1+beta): Prenatal opiate exposure attenuates LPS-induced fever in adult rats: role of interleukin-1beta.

  Direct action of IL-1beta is likely not the cause of the dysfunction reported here.

• 9791060(Interleukin-1): Interleukin-1beta fever in rats: gender difference and estrous cycle influence.

  The fever induced by IL-1beta was found to be significantly higher and more prolonged in females at proestrus than at diestrus.

• 8227975(Prolactin): Poly (adenosine diphosphate-ribose) synthesis in the anterior pituitary of the female rat throughout the estrous cycle: study of possible relation to cell proliferation and prolactin gene expression.

  The increase of PRL messenger RNA from diestrus to proestrus was abolished completely by the administration of nicotinamide , an inhibitor of poly (ADP-ribose) synthesis , to rats at diestrus.

• 3000421(poly-ADP-ribose): Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).

  Poly (adenosine 5 ' - diphosphate ribose) (poly (ADP-ribose)) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide , especially in 0.5 M NaCl and at an alkaline pH..