IL-1 alpha→ADP Ribose Transferases→Poly(ADP-ribose) Polymerases→poly-ADP-ribose

• 17204250(IL-1+alpha): Secretory phospholipase A2 IIA is up-regulated by TNF-alpha and IL-1alpha/beta after transient focal cerebral ischemia in rat.

  Cerebral ischemia initiates an inflammatory response in the brain that is associated with the induction of a variety of cytokines , including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1alpha / beta (IL-1alpha / beta) that contributes to stroke injury.

• 10374629(ADP Ribose Transferases): Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats.

  AIM : To explore the role of poly (ADP-ribose) polymerase (PARP) in focal cerebral ischemia with reperfusion injury.

• 10424667(Poly(ADP-ribose) Polymerases): The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase.

  The activation of poly (ADP-ribose) polymerase (PARP) by free radical-damaged DNA plays a pivotal role in mediating ischemia-reperfusion injury.

• 3158622(poly-ADP-ribose): Influence of poly(ADP-ribose) synthesis inhibitors on the repair of sublethal and potentially lethal damage in gamma-irradiated mammalian cells.

  The influence of poly (ADP-ribose) synthesis inhibitors on mammalian cell radiosensitivity was investigated.