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17465504(SFRP1): Hypermethylation and aberrant expression of Wnt antagonist secreted frizzled-related protein 1 in gastric cancer.
CONCLUSION : SFRP1 inactivation is a common and early event caused mainly by hypermethylation in gastric cancer.
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16410723(Histones): Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer.
Based on the frequency of tumor-specific hypermethylation in this gene , SFRP1 could provide a valuable marker for breast cancer.
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15952054(Poly(ADP-ribose) Polymerases): Gene 33 inhibits apoptosis of breast cancer cells and increases poly(ADP-ribose) polymerase expression.
This suggests that Gene 33 promotes breast cancer cell growth by an anti-apoptotic rather than a mitogenic effect , possibly involving up-regulation of PARP-1.
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15293985(poly-ADP-ribose): Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.
A novel class of quinazolinone derivatives as potent poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors has been discovered.