CXCL1→Phenyl Ethers→1-Naphthylamine→poly-ADP-ribose

• 17619015(CXCL1): Effects of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in a model of intestinal reperfusion injury in mice.

  The effects of these drugs on TNF-alpha production appear to be more relevant than their effects on MMP inhibition.

• 16449942(Phenyl Ethers): Matrix metalloproteinase inhibitor (ONO-4817) attenuates ischemia-reperfusion injury in rat lung.

  Similarly , an increase in the tissue malondialdehyde level in lungs after ischemia-reperfusion was ameliorated by the MMP inhibitor (p (0.01).

• 12686864(1-Naphthylamine): The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.

  PURPOSE : Poly (adenosine diphosphate (ADP) - ribose) polymerase inhibitors have been used successfully to decrease ischemia-reperfusion injury in several organ systems.

• 3000421(poly-ADP-ribose): Nonenzymic adenosine 5'-diphosphate ribosylation of poly(adenosine diphosphate ribose).

  Poly (adenosine 5 ' - diphosphate ribose) (poly (ADP-ribose)) is spontaneously ADP-ribosylated when it is incubated with nicotinamide adenine dinucleotide , especially in 0.5 M NaCl and at an alkaline pH..