MMP-3→Matrix Metalloproteinase 3→poly-ADP-ribose

• 17710450(MMP-3): Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors.

  We structurally characterized the adducts of the catalytic domain of matrix metalloproteinase-3 (MMP3) with three different nonpeptidic inhibitors by solving the solution structure of one adduct (MMP3-N-isobutyl-N - (4-methoxyphenylsulfonyl) glycyl hydroxamic acid) and then by calculating structural models of the other two adducts using a reduced set of experimental NMR data , following a recently proposed procedure (Bertini et al.

• 10422833(Matrix Metalloproteinase 3): X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.

  We have discovered nonpeptidic MMP inhibitors with improved properties , and report here the crystal structures of human stromelysin-1 catalytic domain (SCD) complexed with four of these inhibitors.

• 20092359(poly-ADP-ribose): Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.

  We used X-ray crystallography to determine two structures of the catalytic domain of human PARP2 : the complexes with PARP inhibitors 3-aminobenzamide and ABT-888.