MMP-3→MMP13 protein, human→Organic Chemicals→Carbazoles→poly-ADP-ribose

• 18029177(MMP-3): A novel series of highly selective inhibitors of MMP-3.

  Substitution of a 4-biaryl piperidine sulfonamide core , which binds at the S1 ' subsite of MMP-3 , was optimised to give potent inhibitors of MMP-3 , with greater than 300-fold selectivity over MMP-1 , MMP-2 , MMP-9 and MMP-14.

• 11133099(MMP13 protein, human): Synthesis and activity of selective MMP inhibitors with an aryl backbone.

  A series of novel , MMP-1 sparing arylhydroxamate sulfonamides with activity against MMP-2 and -13 is described.

• 9873598(Organic Chemicals): The synthesis and biological activity of a novel series of diazepine MMP inhibitors.

  A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1 , MMP-9 , and MMP-13 were prepared and evaluated both in vitro and in vivo.

• 17074482(Carbazoles): Novel poly(ADP-ribose) polymerase-1 inhibitors.

  Synthesis and activity of a series of 4-thiazol-yl substituted analogs of novel pyrrolocarbazole 1 as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors have been disclosed.

• 11854472(poly-ADP-ribose): Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia.

  Poly (ADP-ribose) polymerase-1 (PARP-1 , EC) , a nuclear enzyme activated by DNA strand breaks , physiologically participates in DNA repair.