MMP-3→Isoquinolines→Nuclear Proteins→Poly(ADP-ribose) Polymerases→poly-ADP-ribose

• 18029177(MMP-3): A novel series of highly selective inhibitors of MMP-3.

  The design and synthesis of a series of highly selective hydroxamate inhibitors of stromelysin-1 (MMP-3) is described.

• 18409175(Isoquinolines): On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives.

  Among them , we identified the 5-benzoyloxyisoquinolin-1 (2 H) - one derivative as the most selective PARP-2 inhibitor reported so far , with a PARP-2 / PARP-1 selectivity index greater than 60.

• 10364231(Nuclear Proteins): PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase.

  We propose to call this enzyme poly (ADP-ribose) polymerase 2 (PARP-2).

• 1915664(Poly(ADP-ribose) Polymerases): Differential expression of poly(ADP-ribose) polymerase and DNA polymerase beta in rat tissues.

  A good correlation between poly (ADP-ribose) polymerase activity and the level of the transcript of the gene coding for the enzyme was observed in many tissues.

• 6317634(poly-ADP-ribose): Poly(ADP-ribose) synthetase associated to cytoplasmic structures of meiotic cells.

  An active poly (ADP-ribose) synthetase has been found to be associated to mitochondria of frog oocytes and of testis from various species.